2-(Benzooxazol-2-ylsulfanyl)-N-(4-p-tolyl-thiazol-2-yl)-acetamide | 79420-04-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 2-(Benzooxazol-2-ylsulfanyl)-N-(4-p-tolyl-thiazol-2-yl)-acetamide
• 英文别名: 2-(1,3-benzoxazol-2-ylsulfanyl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide
• CAS: 79420-04-5
• 化学式: C₁₉H₁₅N₃O₂S₂
• 分子量: 381.479
• InChiKey: ZUGCONAZZVIPGT-UHFFFAOYSA-N

物化性质

• 熔点：
  242-243 °C(Solv: ethanol (64-17-5))
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  122
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氯-N-(4-对甲苯-2-噻唑)-乙酰胺 、 2-巯基苯并恶唑 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以81%的产率得到2-(Benzooxazol-2-ylsulfanyl)-N-(4-p-tolyl-thiazol-2-yl)-acetamide
  参考文献：
  名称：

  Mahmoud; El-Sherief; Abdel-Rahman, European Journal of Medicinal Chemistry, 1981, vol. 16, # 4, p. 383 - 384

  摘要：

  DOI：

文献信息

• MAHMOUD A. M.; EL-SHERIEF H. A.; ABDEL-RAHMAN A. E., EUR. J. MED. CHEM.-CHIM. THER., 1981, 16, NO 4, 383-384
  作者：MAHMOUD A. M.、 EL-SHERIEF H. A.、 ABDEL-RAHMAN A. E.

  DOI：——

  日期：——
• Microrna modulators and method for identifying and using the same
  申请人：Huang Qihong

  公开号：US20100196357A1

  公开（公告）日：2010-08-05

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying And Using The Same
  申请人：Huang Qihong

  公开号：US20120010177A1

  公开（公告）日：2012-01-12

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• US20140255386A1
  申请人：——

  公开号：US20140255386A1

  公开（公告）日：2014-09-11
• [EN] MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME<br/>[FR] MODULATEURS DE MICROARN ET MÉTHODE D'IDENTIFICATION ET D'UTILISATION ASSOCIÉE
  申请人：WISTAR INST

  公开号：WO2013019469A1

  公开（公告）日：2013-02-07

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.