2-pentyl isocyanate | 142688-48-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-pentyl isocyanate
• 英文别名: 2-isocyanato pentane；2-Isocyanatopentane
• CAS: 142688-48-0
• 化学式: C₆H₁₁NO
• 分子量: 113.159
• InChiKey: HOSRHDUJWMTWRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (propan-2-ylideneamino) N-(3-hydroxyphenyl)carbamate 、 2-pentyl isocyanate 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  DE1913043

  摘要：

  公开号：
• 作为产物：
  描述：

  2-甲基戊醛 在 chromium(VI) oxide 、 叠氮基三甲基硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以69%的产率得到2-Methylpentanoyl azide
  参考文献：
  名称：

  Oxidation of aldehydes to acyl azides by chromic anhydride-azidotrimethylsilane

  摘要：

  Aldehydes are efficiently oxidized to acyl azides by azidotrimethylsilane and chromic anhydride at room temperature (aromatic), or at -10-degrees-C (aliphatic).

  DOI：

  10.1016/s0040-4039(00)79841-8

文献信息

• Imidazole derivatives as histamine receptor H3 (ANT) agonists
  申请人：Institut National de la Sante et de la Recherche Medical

  公开号：US06248765B1

  公开（公告）日：2001-06-19

  Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.

  新型咪唑衍生物作为组胺受体H3拮抗剂和/或激动剂，其制备和治疗用途。用作组胺受体H3激动剂、部分激动剂或拮抗剂的化合物，具有通式(Ia)或(Ib)，其用于制备药物的用途，并公开了在体内揭示这类化合物的激动剂、部分激动剂或拮抗剂活性的方法。
• Development of Chiral <i>N</i>-Alkylcarbamates as New Leads for Potent and Selective H₃-Receptor Antagonists:  Synthesis, Capillary Electrophoresis, and in Vitro and Oral in Vivo Activity
  作者：Astrid Sasse、Katarzyna Kiec-Kononowicz、Holger Stark、Malgorzata Motyl、Sibylle Reidemeister、C. Robin Ganellin、Xavier Ligneau、Jean-Charles Schwartz、Walter Schunack

  DOI：10.1021/jm9804376

  日期：1999.2.1

  N-2-heptylcarbamate showed a stereoselective differentiation in their pharmacological effect in vivo (ED50 of 0.39 mg/kg for the (S)-derivative vs 1.5 mg/kg for the (R)-derivative) most probably caused by differences in pharmacokinetic parameters. H1- and H2-receptor activities were determined for some of the novel carbamates, demonstrating that they have a highly selective action at the histamine H3 receptor

  制备具有N-烷基链的作为3-（1H-咪唑-4-基）丙醇的衍生物的新型氨基甲酸酯作为组胺H3-受体拮抗剂。N-烷基侧链与甲基的分支产生手性化合物，其通过Mitsunobu方案改编的Gabriel合成立体定向地合成。通过毛细管电泳（CE）测定某些手性化合物的光学纯度（ee> 95％）。在大鼠大脑皮层突触体上的组胺H3受体功能测试中，所研究的化合物显示出明显的高拮抗剂活性（Ki值为4.1-316 nM）。在豚鼠回肠的外周模型中观察到类似的H3受体拮抗剂活性。通过体外测定未发现手性拮抗剂的H3受体的立体选择性鉴别。口服给药后，还在小鼠体内筛选所有化合物的中心H3受体拮抗剂活性。大多数化合物是H3受体介导的脑Ntau-甲基组胺水平增强的有效剂。N-2-庚基氨基甲酸酯的对映异构体在体内药理作用中表现出立体选择性差异（（S）衍生物的ED50为0.39 mg / kg，而（R）衍生物的ED50为1.5 mg
• Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates
  作者：Dorota Łażewska、Małgorzata Więcek、Xavier Ligneau、Tim Kottke、Lilia Weizel、Roland Seifert、Walter Schunack、Holger Stark、Katarzyna Kieć-Kononowicz

  DOI：10.1016/j.bmcl.2009.10.005

  日期：2009.12

  A series of imidazole-containing (non-)chiral carbamates were tested at human histamine H-3 receptor (H3R). All compounds displayed K-i values below 100 nM. A trend for a stereoselectivity at human H3R was observed for the chiral alpha-branched ligands. Selected compounds were also tested at human histamine H-4 receptor and showed moderate to weak affinities (118-1460 nM). (C) 2009 Elsevier Ltd. All rights reserved.
• Synthesis and Pharmacological Evaluation of Novel Nitrobenzenic Thromboxane Modulators as Antiplatelet Agents Acting on Both the Alpha and Beta Isoforms of the Human Thromboxane Receptor
  作者：Julien Hanson、Denis Reynaud、Na Qiao、Philippe Devel、Anne-Lise Moray、Jean-François Renard、Leanne P. Kelley、Jean-Yves Winum、Jean-Louis Montero、B. Therese Kinsella、Bernard Pirotte、Cecil R. Pace-Asciak、Jean-Michel Dogné

  DOI：10.1021/jm060108a

  日期：2006.6.1

  Thromboxane A(2) ( TXA(2)) is an arachidonic acid metabolite involved in pathologies such as stroke, myocardial infarction, and atherosclerosis. Consequently, the design of TXA2 receptor ( TP) antagonists remains of great interest in cardiovascular medicine. The actions of TXA2 are mediated by its specific G-protein coupled receptor of which two alternative spliced isoforms, TP alpha and TP beta, have been described in humans. In this study, we report the synthesis of a series of original N-alkyl-N'-[2-( cycloalkyl, alkylaryl)-5-nitrobenzenesulfonyl] urea and N-alkyl-N'-[ 2-( alkylaryl)-5-nitrobenzenesulfonyl]-N"-cyanoguanidines and outline their pharmacological evaluation using the individual TP alpha and TP beta isoforms. Among compounds analyzed, several of them exhibited greater affinity and/or functional activity for either TP alpha or TP beta. The most promising molecules were also found to be antiplatelet agents. From the present results, structural features involved in isoform selectivity can be proposed, and thereby several lead compounds have been identified for the further development of selective TP isoform antagonists.
• Synthesis and Insecticidal Activity of Novel Pyrazole Methanesulfonates
  作者：Bruce L. Finkelstein、Christopher J. Strock

  DOI：10.1002/(sici)1096-9063(199708)50:4<324::aid-ps596>3.0.co;2-d

  日期：1997.8