2-[1-(羟甲基)乙基]唑啉 | 13670-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 中文名称: 2-[1-(羟甲基)乙基]唑啉
• 中文别名: 2-(1-(羟基甲基)乙基)-噁唑啉
• 英文名称: 2-(4,5-dihydro-oxazol-2-yl)-propan-1-ol
• 英文别名: 2-(α-hydroxymethylethyl)-2-oxazoline；2-(3-hydroxy-2-propyl)-2-oxazoline；2-<Δ²-Oxazolin-2-yl>-propan-1-ol；2-Oxazolin-2-yl-propan-1-ol；2-Oxazoleethanol, 4,5-dihydro-beta-methyl-；2-(4,5-dihydro-1,3-oxazol-2-yl)propan-1-ol
• CAS: 13670-31-0
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: SWYMJLYPXAXHBJ-UHFFFAOYSA-N

物化性质

• 密度：
  1.1240 g/mL at 25 °C(lit.)
• 闪点：
  190 °F

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36
• WGK Germany：
  3
• 海关编码：
  2934999090
• 安全说明：
  S26

制备方法与用途

用途：2-异丙烯基-2-氧唑啉（IPO）的前体

反应信息

• 作为反应物：
  描述：

  2-[1-(羟甲基)乙基]唑啉 生成 2-异丙烯基-2-氧唑啉
  参考文献：
  名称：

  Seeliger,W. et al., Angewandte Chemie, 1966, vol. 78, # 20, p. 913 - 927

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2-羟乙基)酰丙胺 在 aluminum oxide 三乙胺 作用下， 320.0 ℃ 、2.67 kPa 条件下， 生成 2-[1-(羟甲基)乙基]唑啉
  参考文献：
  名称：

  Seeliger,W. et al., Angewandte Chemie, 1966, vol. 78, # 20, p. 913 - 927

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR PRODUCING ISOCYANATES<br/>[FR] PROCÉDÉ DE PRODUCTION D'ISOCYANATES
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2011130032A1

  公开（公告）日：2011-10-20

  The invention relates a process for producing isocyanates comprising the steps of a) providing an azolide and optionally a solvent, and b) adding an acid at a temperature below about 40C. The invention also relates to the isocyanate obtainable by such a process.

  该发明涉及一种生产异氰酸酯的方法，包括以下步骤：a)提供一种氮杂环酯和可选的溶剂，b)在约40摄氏度以下的温度下加入酸。该发明还涉及通过这种方法获得的异氰酸酯。
• Process for producing isocyanates
  申请人：3M Innovative Properties Company

  公开号：EP2377847A1

  公开（公告）日：2011-10-19

  The invention relates a process for producing isocyanates comprising the steps of a) providing an azolide and optionally a solvent, and b) adding an acid at a temperature below about 40°C. The invention also relates to the isocyanate obtainable by such a process.

  该发明涉及一种生产异氰酸酯的方法，包括以下步骤：a)提供一种环氧酮酯和可选的溶剂，b)在低于约40°C的温度下加入酸。该发明还涉及通过这种方法获得的异氰酸酯。
• Vinyloxazoline monomer and preparation thereof
  申请人：The Dow Chemical Company

  公开号：US04709039A1

  公开（公告）日：1987-11-24

  This invention relates to new organic compounds, including 2-(2-allyloxy-1-methylethyl)-2-oxazoline and 2-(vinylbenzyloxy-1-methylethyl)-2-oxazoline. Its method of preparation comprises condensing 2-(3-hydroxy-2-propyl)-2-oxazoline with allyl chloride and vinylbenzyl chloride, respectively, in a phase transfer process. The invention is also directed to a method of copolymerizing 2-ethyloxazoline with such compounds.

  本发明涉及一种新的有机化合物，包括2-(2-烯丙氧基-1-甲基乙基)-2-噁唑啉和2-(乙烯基苄氧基-1-甲基乙基)-2-噁唑啉。其制备方法包括在相转移过程中，将2-(3-羟基-2-丙基)-2-噁唑啉分别与烯丙基氯和乙烯基苄氯缩合。该发明还涉及一种与这些化合物共聚合2-乙氧噁唑啉的方法。
• Method for preparing 2-alkenyl-2-oxazolines
  申请人：The Dow Chemical Company

  公开号：US04376861A1

  公开（公告）日：1983-03-15

  The process comprises the steps of: (A) reacting by contacting an anhydrous or substantially anhydrous 2-alkyl-2-oxazoline with formaldehyde in a molar ratio of at least about 1.5 moles of 2-alkyl-2-oxazoline per mole of formaldehyde, thereby forming 2-(.alpha.-hydroxymethylalkyl)-2-oxazoline, (B) recovering the 2-(.alpha.-hydroxymethylalkyl)-2-oxazoline from the reaction product of step (A), and (C) reacting by contacting the 2-(.alpha.-hydroxymethylalkyl)-2-oxazoline and step B with an alkali or alkaline earth metal hydroxide, thereby forming 2-alkenyl-2-oxazoline. As an example, step A was conducted by reacting 2-ethyl-2-oxazoline (4 moles) having less than 1,000 ppm of water with paraformaldehyde (1 mole) at a reaction temperature of 100.degree. C. for approximately 5.5 hours. The excess oxazoline reactant was removed along with water as "overheads" by fractional distillation of the reaction product, leaving the 2-(.alpha.-hydroxymethylethyl)-2-oxazoline in approximately 96 percent yield. Step C was then conducted by continuously adding the 2-(.alpha.-hydroxymethylethyl)-2-oxazoline to a stirred solution of sodium hydroxide in the mono-methyl ether of triethylene glycol at a temperature of from 100.degree.-105.degree. C. Under these conditions, the 2-isopropenyl-2-oxazoline and water were volatilized and recovered from the overheads. The product yield was approximately 98 percent of theory.

  该过程包括以下步骤：（A）通过将无水或基本无水的2-烷基-2-噁唑烷与甲醛以至少约1.5摩尔2-烷基-2-噁唑烷/摩尔甲醛的摩尔比反应，从而形成2-（α-羟甲基烷基）-2-噁唑烷，（B）从步骤（A）的反应产物中回收2-（α-羟甲基烷基）-2-噁唑烷，以及（C）通过将2-（α-羟甲基烷基）-2-噁唑烷和步骤B与碱金属或碱土金属氢氧化物接触反应，从而形成2-烯基-2-噁唑烷。例如，步骤A通过在反应温度为100°C左右，将水含量小于1000 ppm的2-乙基-2-噁唑烷（4摩尔）与多聚甲醛（1摩尔）反应约5.5小时进行。通过分馏反应产物，去除过量的噁唑烷反应物和水，得到约96％收率的2-（α-羟甲基乙基）-2-噁唑烷。然后，步骤C通过不断将2-（α-羟甲基乙基）-2-噁唑烷连续加入三乙二醇单甲醚中的氢氧化钠搅拌溶液中，在100°C-105°C的温度下进行。在这些条件下，2-异丙烯基-2-噁唑烷和水被挥发并从顶部回收。产品产率约为理论产率的98％。
• Assembly of a semiconductor die attached to substrate with oxazoline derivative bearing an electron donor or acceptor functionality
  申请人：Musa M. Osama

  公开号：US20060263928A1

  公开（公告）日：2006-11-23

  An assembly of a semiconductor die attached to a substrate is made with a composition comprising compounds that contain an oxazoline functionality and an electron acceptor or an electron donor functionality. Electron donor functionalities include styrenic, cinnamyl, and vinyl ether groups. Electron acceptor functionalities include maleimide, acrylate, fumarate, and maleate groups. An exemplary compound has the structure: formula (I).

  一种含有氧唑啉官能团和电子受体或电子给体官能团的化合物组成的半导体芯片装配件，其中电子给体官能团包括苯乙烯基、肉桂基和乙烯醚基；电子受体官能团包括马来酰亚胺基、丙烯酸酯基、富马酸酯基和马来酸酯基。一种典型的化合物具有结构式（I）。