3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan | 858796-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: 3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan
• 英文别名: 3,6-dimethoxyhexahydrofurano[3,2-b]furan；3,6-dimethoxyhexahydrofuro[3,2-b]furan；Arlasolve DMI
• CAS: 858796-27-7
• 化学式: C₈H₁₄O₄
• mdl: MFCD00129931
• 分子量: 174.197
• InChiKey: MEJYDZQQVZJMPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硫酸二甲酯 、 isosorbide 在 氢氧化钾 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.5h， 以96%的产率得到3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan
  参考文献：
  名称：

  Reactions in Slightly Hydrated Solid/Liquid Heterogeneous Media: The Methylation Reaction with Dimethyl Sulfoxide

  摘要：

  在固体氢氧化钾和少量水的存在下，使用二甲基硫酸酯和1,4-二氧六环或三甘醇的定量摩尔量对醇和酚进行O-甲基化，是一种合成甲醚的高产率和高选择性的有用方法。该反应中二甲基硫酸酯的完全消耗避免了与含有过量这种有毒试剂的反应混合物后处理相关的问题。

  DOI：

  10.1055/s-1986-31729

文献信息

• [EN] MAP4K4 INHIBITORS<br/>[FR] INHIBITEURS DE MAP4K4
  申请人：IMPERIAL INNOVATIONS LTD

  公开号：WO2019073253A1

  公开（公告）日：2019-04-18

  This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I).

  这项发明涉及含有吡咯吡嘧啶的化合物，这些化合物可能作为丝裂原活化蛋白激酶激酶激酶激酶-4（MAP4K4）的抑制剂而有用。该发明还涉及利用这些含有吡咯吡嘧啶的化合物，例如在治疗方法中的使用。还提供了生产本发明化合物的方法以及它们的使用方法。具体而言，本发明涉及式（I）的化合物。
• [EN] PROCESS FOR THE PRODUCTION OF FURFURAL<br/>[FR] PROCÉDÉ DE PRODUCTION DE FURFURAL
  申请人：DU PONT

  公开号：WO2013101999A1

  公开（公告）日：2013-07-04

  Furfural is produced by mixing an aqueous feedstock solution containing C5 sugar and/or C6 sugar with a heated, high boiling, water-miscible solvent, such as sulfolane, and a soluble acid catalyst. Furfural product and water are distilled off through a multistage distillation column, leaving non-volatile solvent behind. Typical furfural yields with sulfolane as the reaction solvent are about 80% at as high as 99% conversion. Also, certain by-products (e.g., humins) solubilized in the reaction solvent can be precipitated by addition of water or aqueous feedstock solution and then removed by filtration, thereby providing a convenient and effective way of removing these undesirable byproducts from the reaction mixture.

  糠醛是通过将含有C5糖和/或C6糖的水溶性原料溶液与加热的高沸点、可溶于水的溶剂（如磺酰胺）和可溶的酸催化剂混合而产生的。通过多级蒸馏柱蒸馏出糠醛产品和水，留下不挥发的溶剂。在使用磺酰胺作为反应溶剂的情况下，典型的糠醛产率为80％，转化率高达99％。此外，反应溶剂中溶解的某些副产物（如褐质物）可以通过加水或水性原料溶液沉淀，然后通过过滤去除，从而提供了一种方便有效的方法，以从反应混合物中去除这些不良副产物。
• PROCESS FOR THE PRODUCTION OF FURFURAL
  申请人：E I DU PONT DE NEMOURS AND COMPANY

  公开号：US20130172581A1

  公开（公告）日：2013-07-04

  Furfural is produced by mixing an aqueous feedstock solution containing C 5 sugar and/or C 6 sugar with a heated, high boiling, water-miscible solvent, such as sulfolane, and a soluble acid catalyst. Furfural product and water are distilled off through a multistage distillation column, leaving non-volatile solvent behind. Typical furfural yields with sulfolane as the reaction solvent are about 80% at as high as 99% conversion. Also, certain by-products (e.g., humins) solubilized in the reaction solvent can be precipitated by addition of water or aqueous feedstock solution and then removed by filtration, thereby providing a convenient and effective way of removing these undesirable byproducts from the reaction mixture.

  糠醛是通过将含有C5糖和/或C6糖的水性原料溶液与加热的高沸点、亲水的溶剂（如磺酰胺）和可溶性酸催化剂混合而产生的。通过多级蒸馏柱蒸馏出糠醛产品和水，留下不挥发的溶剂。使用磺酰胺作为反应溶剂的典型糠醛产率为80％，转化率高达99％。此外，反应溶剂中溶解的某些副产物（例如褐质物）可以通过加水或水性原料溶液使其沉淀，然后通过过滤去除，从而提供了一种方便有效的方法来从反应混合物中去除这些不良副产物。
• ISOMANNIDE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
  申请人：SANOFI

  公开号：US20150336979A1

  公开（公告）日：2015-11-26

  The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, inflammation or could show beneficial effects in pain, dyslipidemia and atherosclerosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

  本发明涉及式(I)的化合物，其中R1，R11，R12和X具有声明中指示的含义。公式I的化合物是有价值的药理活性化合物。它们是高效、选择性可溶性环氧酶抑制剂，适用于肾衰竭、糖尿病性肾病、2型糖尿病、炎症的治疗和预防，或者在疼痛、血脂异常和动脉粥样硬化方面可能显示出有益的效果。本发明还涉及制备式(I)化合物的方法，它们的用途，特别是作为药物中的活性成分，以及包含它们的制药制剂。
• Liquid-crystalline medium, compounds, and high-frequency components
  申请人：MERCK PATENT GMBH

  公开号：US10858587B2

  公开（公告）日：2020-12-08

  Liquid-crystalline media containing one or more compounds of formulae I-1, I-2 and/or I-3 and one or more compounds of formulae II and/or III and components containing these media for high-frequency technology, in particular phase shifters and microwave array antennas.

  液晶介质含有一个或多个I-1、I-2和/或I-3式化合物和一个或多个II和/或III式化合物，以及包含这些介质的组件，用于高频技术，特别是相移器和微波阵列天线。