2-[2-(2-吡啶基)乙基]苯胺 | 50385-28-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[2-(2-吡啶基)乙基]苯胺
• 中文别名: 2-(2-吡啶-2-基乙基)苯胺
• 英文名称: 2-(2-pyridin-2-yl-ethyl)-aniline
• 英文别名: 2-(2-[2]pyridyl-ethyl)-aniline；2-(2-[2]Pyridyl-aethyl)-anilin；o-aminophenethylpyridine；2-(2-Pyridin-2-ylethyl)aniline
• CAS: 50385-28-9
• 化学式: C₁₃H₁₄N₂
• mdl: MFCD05256417
• 分子量: 198.268
• InChiKey: KDAOXFXGTWSXIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2-[2-(2-吡啶基)乙基]苯胺 在 盐酸 、 sodium carbonate 、 sodium nitrite 、 苯 作用下， 生成 2-(o-Chlorphenethyl)-pyridin
  参考文献：
  名称：

  666.核间环化。第二部分 Pschorr反应在邻氨基-α-苯基肉桂酸的某些取代衍生物上的应用

  摘要：

  DOI：

  10.1039/jr9490003172
• 作为产物：
  描述：

  1-(2-硝基苯基)-2-吡啶-2-基-乙醇 在 磷化氢 、 氢碘酸 作用下， 生成 2-[2-(2-吡啶基)乙基]苯胺
  参考文献：
  名称：

  666.核间环化。第二部分 Pschorr反应在邻氨基-α-苯基肉桂酸的某些取代衍生物上的应用

  摘要：

  DOI：

  10.1039/jr9490003172

文献信息

• Studies on Antiulcer Drugs. V. Synthesis and Antiulcer Activity of Aralkylbenzazoles.
  作者：Yousuke KATSURA、Yoshikazu INOUE、Masaaki TOMOI、Hisashi TAKASUGI

  DOI：10.1248/cpb.40.2062

  日期：——

  2-alkylamino-5- or 6-aralkyl-substituted benzazoles were synthesized and tested for histamine H2-receptor antagonist and anti-stress ulcer activities. These new compounds showed little or no histamine H2-receptor antagonist activity in contrast to imidazo[1,2-a]pyridine analogues (I). On antiulcer assay, however, some pyridine derivatives (II) exerted higher activity than the reference compounds, sofalcone

  合成了一系列的2-烷基氨基-5-或6-芳烷基取代的苯并测试组胺H 2受体拮抗剂和抗应激溃疡活性。与咪唑并[1,2-a]吡啶类似物（I）相反，这些新化合物几乎没有或没有组胺H2-受体拮抗剂活性。然而，在抗溃疡试验中，一些吡啶衍生物（Ⅱ）的活性比参比化合物索法酮，硫糖铝酸盐和西咪替丁高。讨论了这些化合物的构效关系。
• Substituted piperidines
  申请人：Mead Johnson & Company

  公开号：US03931195A1

  公开（公告）日：1976-01-06

  The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.

  这些化合物属于异环类2-苯乙基哌啶，其在苯乙基部分的邻位具有酰胺取代基。邻位的取代基包括甲酰胺基、苯甲酰胺基、肉桂酰胺基、2-噻吩羧酰胺基、烷磺酰胺基和烷酰胺基。它们可用作抗心律失常和/或抗5-羟色胺药物。这些新化合物是通过适当取代的o-氨基苯乙基哌啶与羰基或磺酰卤或酐的反应制备的。本发明的典型实施例包括4-甲氧基-2'-[2-(1-甲基-2-哌啶基)乙基]苯甲酰胺和2'-[2-(1-甲基-2-哌啶基)乙基]肉桂酰胺。
• Substituted piperidines therapeutic process and compositions
  申请人：Mead Johnson & Company

  公开号：US04064254A1

  公开（公告）日：1977-12-20

  The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.

  这些化合物属于2-苯乙基哌啶的杂环类化合物，其苯乙基部分的邻位位置有一个酰胺基取代基。邻位位置的取代基包括甲酰胺基、苯甲酰胺基、肉桂酰胺基、2-噻吩羧酰胺基、烷基磺酰胺基和烷酰胺基。它们可用作抗心律失常和/或抗血清素药物。这些新型化合物是通过适当取代的邻氨基苯乙基哌啶与羰基或磺酰卤化物或酐反应制备而成。该发明的典型实施例包括4-甲氧基-2'-[2-(1-甲基-2-哌啶基)乙基]苯甲酰胺和2'-[2-(1-甲基-2-哌啶基)乙基]肉桂酰胺。
• Hybrid tea rose plant named ‘MEIVANAE’
  申请人：THE CONARD-PYLE COMPANY

  公开号：USPP030812P2

  公开（公告）日：2019-08-20

  A new and distinct variety of Hybrid Tea Rose plant, herein referred to by its cultivar name, ‘MEIVANAE’, is provided which forms abundantly on a nearly continuous basis attractive, cup-shaped, powdery-yellow/orange colored blossoms with a light pink margin which emit a fruity fragrance. Attractive, semi-glossy, very dense foliage is formed, which contrasts beautifully with the blossoms. The disease tolerance is very good; particularly against Black Spot and Oidium. The new variety is well suited for proving attractive ornamentation in the landscape and is very floriferous.

  提供了一种新的、独特的杂交茶花植物品种，其品种名称为“MEIVANAE”，它在几乎连续的基础上形成了丰富的、吸引人的、杯形的、粉黄/橙色的花朵，带有淡粉色的边缘，散发着果香。形成了具有吸引力、半光泽、非常密集的叶子，与花朵形成美丽的对比。疾病耐受性非常好，特别是对于黑斑病和白粉病。这个新品种非常适合在景观中提供吸引人的装饰，而且开花非常多。
• Miniature rose plant named ‘MEIBENBINO’
  申请人：THE CONARD-PYLE COMPANY

  公开号：USPP030811P3

  公开（公告）日：2019-08-20

  A new and distinct variety of Miniature Rose plant, herein referred to by its cultivar name, ‘MEIBENBINO’, is provided which forms very abundantly on a nearly continuous basis attractive, cup-shaped, red colored blossoms. Attractive, glossy, very dense foliage is formed, which contrasts beautifully with the blossoms. The disease tolerance is very good, particularly against Black Spot. The new variety is well suited for proving attractive ornamentation in the landscape.

  一种新的迷你玫瑰植物品种，以其培育品种名称“MEIBENBINO”命名，其形成的美丽、杯状、红色花朵非常丰富，几乎连续开放。形成了美丽、有光泽、非常密集的叶子，与花朵形成了美丽的对比。抗病性能非常好，特别是对黑斑病的抵抗力。这个新品种非常适合在景观中提供美丽的装饰。