3-methyl-1-(phenylsulfonyl)pentane | 126644-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-1-(phenylsulfonyl)pentane
• 英文别名: phenyl 3-methylpentyl sulfone；3-methylpentyl phenyl sulfone；(3-Methylpentane-1-sulfonyl)benzene；3-methylpentylsulfonylbenzene
• CAS: 126644-88-0
• 化学式: C₁₂H₁₈O₂S
• 分子量: 226.34
• InChiKey: TYIVGTBNQMUXQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-phenylthio-1-trimethylsilylethene 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 3-methyl-1-(phenylsulfonyl)pentane
  参考文献：
  名称：

  Directed lithiation of chlorobenzenes. Regioselectivity and application to a short synthesis of benzocyclobutenes

  摘要：

  DOI：

  10.1021/jo00298a045

文献信息

• PYRIDINE-3-CARBOXYAMIDE DERIVATIVE
  申请人：Kitamura Takahiro

  公开号：US20110237590A1

  公开（公告）日：2011-09-29

  To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.

  提供一种新型JAK3抑制剂，可用作器官移植中的预防和/或治疗剂，以及风湿性关节炎、多发性硬化、系统性红斑狼疮、干燥综合征、贝赫切特病、I型糖尿病、自身免疫性甲状腺炎、特发性血小板减少性紫癜、溃疡性结肠炎、克罗恩病、哮喘、过敏性鼻炎、特应性皮炎、接触性皮炎、荨麻疹、湿疹、牛皮癣、过敏性结膜炎、葡萄膜炎、白血病等疾病的预防和治疗。通式（1）所代表的吡啶-3-羧酰胺衍生物： 或其盐或溶剂化合物。
• Zn/CuI-Mediated Coupling of Alkyl Halides with Vinyl Sulfones, Vinyl Sulfonates, and Vinyl Sulfonamides
  作者：Matthew M. Zhao、Chuanxing Qu、Joseph E. Lynch

  DOI：10.1021/jo050500g

  日期：2005.8.1

  A novel high-yielding Zn/CuI-mediated coupling method of alkyl halides with vinyl sulfones, vinyl sulfonates, and vinyl sulfonamides is described. This protocol is applicable for primary, secondary, and tertiary alkyl iodides and bromides. Alkyl chlorides and aryl and vinyl halides were unreactive under the reaction conditions. Formamide was found to be a superior solvent for obtaining high yields

  描述了一种新颖的高产Zn / CuI介导的烷基卤与乙烯基砜，乙烯基磺酸盐和乙烯基磺酰胺的偶联方法。该协议适用于伯，仲和叔烷基碘和溴化物。烷基氯与芳基和乙烯基卤化物在反应条件下不反应。发现甲酰胺是获得高产率的优良溶剂。
• Indium as a radical initiator in aqueous media: intermolecular alkyl radical addition to CN and CC bond
  作者：Hideto Miyabe、Masafumi Ueda、Azusa Nishimura、Takeaki Naito

  DOI：10.1016/j.tet.2004.03.040

  日期：2004.5

  The carbon–carbon bond-forming method in aqueous media was investigated by using indium as a single-electron transfer radical initiator. The indium-mediated intermolecular alkyl radical addition to imine derivatives and electron-deficient CC bond proceeded effectively.

  通过使用铟作为单电子转移自由基引发剂，研究了在水介质中形成碳-碳键的方法。铟介导的亚胺衍生物的分子间烷基加成和电子缺陷的CC键有效地进行。
• Indium-Mediated Intermolecular Alkyl Radical Addition to Electron-Deficient CN Bond and CC Bond in Water
  作者：Hideto Miyabe、Masafumi Ueda、Azusa Nishimura、Takeaki Naito

  DOI：10.1021/ol017013h

  日期：2002.1.1

  see text] The intermolecular alkyl radical addition to imine derivatives was studied in aqueous media by using indium as a single-electron-transfer radical initiator. The one-pot reaction based on radical addition to glyoxylic hydrazone provided a convenient method for preparing the alpha-amino acids. The indium-mediated radical addition to an electron-deficient C=C bond also proceeded effectively to

  [反应：见正文]通过使用铟作为单电子转移自由基引发剂，在水性介质中研究了亚胺衍生物的分子间烷基加成反应。基于自由基加成至乙醛酸的一锅法反应提供了一种方便的制备α-氨基酸的方法。铟介导的自由基向电子缺乏的C = C键的加成也有效地进行，以提供在水性介质中形成新的碳-碳键的方法。
• 4-PREGENEN-11SS-17-21-TRIOL-3,20-DIONE DERIVATIVES FOR THE TREATMENT OF OCULAR CONDITIONS
  申请人：ALLERGAN, INC.

  公开号：EP2776040B1

  公开（公告）日：2020-04-22