(E)-1-chloro-4-(4-fluoro-4,4-bis(phenylsulfonyl)but-1-enyl)benzene | 1203825-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-chloro-4-(4-fluoro-4,4-bis(phenylsulfonyl)but-1-enyl)benzene
• 英文别名: (E)-1-chloro-4-(4-fluoro-4,4-bis(phenylsulfonyl)but-3-enyl)benzene；1-[(E)-4,4-bis(benzenesulfonyl)-4-fluorobut-1-enyl]-4-chlorobenzene
• CAS: 1203825-64-2
• 化学式: C₂₂H₁₈ClFO₄S₂
• 分子量: 464.966
• InChiKey: LZOLNBCHGGVUCO-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  氟双(苯基磺酰基)甲烷 、 1-氯-4-(1-丙炔-1-基)苯 在 四(三苯基膦)钯 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以91%的产率得到(E)-1-chloro-4-(4-fluoro-4,4-bis(phenylsulfonyl)but-1-enyl)benzene
  参考文献：
  名称：

  Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles

  摘要：

  A facile palladium-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones in the presence of acetic acid has been achieved. By using different alpha-substituted fluoro(phenyisulfonyl)methane derivatives, a variety of allylated monofluoromethyl compounds were obtained with high regio- and stereoselectivity. Substrate scope and limitation were also examined, and it was found that the reaction was amenable to both 1-aryl-substituted propynes and 3-aryl-substituted propynyl ethers. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.126

文献信息

• Highly regioselective Pd-catalyzed allylic alkylation of fluorobis(phenylsulfonyl)methane
  作者：Xiaoming Zhao、Dongge Liu、Shengcai Zheng、Ning Gao

  DOI：10.1016/j.tetlet.2010.11.132

  日期：2011.2

  A highly regioselective palladium-catalyzed allylic alkylation of fluorobis(phenylsulfonyl)methane has been studied. Using different allylic carbonates, a variety of terminal mono-fluoromethylated compounds were achieved in 85–99% yields with high regioselectivities.

  研究了氟双（苯基磺酰基）甲烷的高度区域选择性钯催化的烯丙基烷基化。使用不同的烯丙基碳酸酯，可以以85-99％的产率获得各种末端单氟甲基化化合物，并具有较高的区域选择性。