7-Methoxy-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine | 101908-45-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 7-Methoxy-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine
• 英文别名: 4-methyl-7-methoxy-3,4-dihydro-2H-[1,4]benzoxazine；7-methoxy-4-methyl-2,3-dihydro-1,4-benzoxazine
• CAS: 101908-45-6
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: CKHMXIDBZYILFJ-UHFFFAOYSA-N

物化性质

• 沸点：
  305.2±42.0 °C(Predicted)
• 密度：
  1.103±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Methoxy-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine 在 sodium tetrahydroborate 、 三氟乙酸 作用下， 生成 4,7-Dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine
  参考文献：
  名称：

  Synthesis and Reactions of 3,4-dihydro-2H-1,4-benzoxazine Derivatives

  摘要：

  Several 3,4-dihydro-2H-1,4-benzoxazine derivatives were prepared from commercially available benzoxazoles by use of an efficient two step sequence. Aryl functionalization reactions allowing access to further benzoxazine derivatives are also described.

  DOI：

  10.3987/com-93-6523
• 作为产物：
  描述：

  2-甲氨基苯酚 在 sodium tetrahydroborate 、 potassium carbonate 、 三氯氧磷 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 72.0h， 生成 7-Methoxy-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine
  参考文献：
  名称：

  Synthesis and Reactions of 3,4-dihydro-2H-1,4-benzoxazine Derivatives

  摘要：

  Several 3,4-dihydro-2H-1,4-benzoxazine derivatives were prepared from commercially available benzoxazoles by use of an efficient two step sequence. Aryl functionalization reactions allowing access to further benzoxazine derivatives are also described.

  DOI：

  10.3987/com-93-6523

文献信息

• Diaminopyrimidines as P2X3 and P2X2/3 antagonists
  申请人：Broka Allen Chris

  公开号：US20050209260A1

  公开（公告）日：2005-09-22

  Compounds and methods for treating diseases mediated by a P2X 3 and/or a P2X 2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein.

  用于治疗由P2X3和/或P2X2/3受体拮抗剂介导的疾病的治疗化合物和方法，该方法包括向有需要的受试者施用有效量的式I化合物：或其药学上可接受的盐、溶剂化物或前药，其中D、X、Y、R1、R2、R3、R4、R5、R6、R7和R8如本文所定义。
• Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
  申请人：Broka Allen Chris

  公开号：US20070049609A1

  公开（公告）日：2007-03-01

  Methods for treating respiratory and gastrointestinal diseases mediated by a P2X 3 and/or a P2X 2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein.

  用于治疗由P2X3和/或P2X2/3受体拮抗剂介导的呼吸系统和胃肠道疾病的方法，包括向有此需要的受试者施用有效量的式(I)化合物：或其药学上可接受的盐，其中D、X、Y、R1、R2、R3、R4、R5、R6、R7和R8如本文所定义。
• [EN] DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS<br/>[FR] DIAMINOPYRIMIDINES UTILISEES EN TANT QU'ANTAGONISTES DE P2X3 ET P2X2/3
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005095359A1

  公开（公告）日：2005-10-13

  Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonists, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

  本发明涉及用于治疗由P2X3和/或P2X2/3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向需要治疗的受体中给予公式（I）的化合物或其药学上可接受的盐、溶剂或前药的有效量，其中D、X、Y、R1、R2、R3、R4、R5、R6、R7和R8如本文所定义。
• Partially hydrogenated pyrazolo, pyrimido and thiazolo[1,4]benzoxazines
  申请人：Eli Lilly and Company

  公开号：US04552956A1

  公开（公告）日：1985-11-12

  Pyrazolo, pyrimido and thiazolo[1,4]benzoxazines, useful as dopamine agonists.

  Pyrazolo、pyrimido和thiazolo [1,4]苯并噁嗪，可用作多巴胺激动剂。
• Partially hydrogenated intermediate pyrazolo, pyrimido and
  申请人：Eli Lilly and Company

  公开号：US04587336A1

  公开（公告）日：1986-05-06

  Intermediates useful for the preparation of pyrazolo, pyrimido and thiazolo[1,4]benzoxazines, useful as dopamine agonists.

  中间体对于制备吡唑并、嘧啶并和噻唑并[1,4]苯并噁嗪非常有用，这些化合物作为多巴胺激动剂具有用途。