cis-2-hydroxy-4-methyltetrahydropyran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: cis-2-hydroxy-4-methyltetrahydropyran
• 英文别名: (2R,4S)-4-methyloxan-2-ol
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: SMFZAIRMNYPZLI-NTSWFWBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis-2-hydroxy-4-methyltetrahydropyran 在 对甲苯磺酸 作用下， 以 氘代氯仿 、 一氟三氯甲烷 为溶剂， 生成 Opt.-inakt. Bis-<4-methyl-tetrahydro-pyranyl-(2)>-aether 、 trans-2-hydroxy-4-methyltetrahydropyran
  参考文献：
  名称：

  Experimental studies of the anomeric effect

  摘要：

  DOI：

  10.1016/s0040-4020(01)86912-x
• 作为产物：
  描述：

  2-Butoxy-3,4-dihydro-4-methyl-2H-pyran 在 水 、 phosphorus pentoxide 作用下， 生成 cis-2-hydroxy-4-methyltetrahydropyran
  参考文献：
  名称：

  Experimental studies of the anomeric effect

  摘要：

  DOI：

  10.1016/s0040-4020(01)86912-x

文献信息

• Sulfur(VI) fluoride compounds and methods for the preparation thereof
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US10765645B2

  公开（公告）日：2020-09-08

  This application describes a compound represented by Formula (I): YZX1—S(O)(X2)F)m]n  (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.

  本申请描述了一种由式 (I) 表示的化合物： YZX1-S(O)(X2)F)m]n (I) 其中Y 是生物活性有机核心基团，包括芳基、杂芳基、非芳香烃基和非芳香杂环基中的一个或多个，Z 与之共价键合；n 是 1、2、3、4 或 5；m 是 1 或 2；Z是O、NR或N；X1是共价键或-CH2CH2-，X2是O或NR；R包括H或选自芳基、杂芳基、非芳香烃基和非芳香杂环基的取代或未取代基团。此外，还描述了制备这些化合物的方法、使用这些化合物的方法以及包含这些化合物的药物组合物。
• SULFUR (VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US20200397719A1

  公开（公告）日：2020-12-24

  This application describes a compound represented by Formula (I): wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X 1 is a covalent bond or —CH 2 CH 2 —, X 2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.
• Experimental studies of the anomeric effect
  作者：Harold Booth、Khedhair A. Khedhair、Simon A. Readshaw

  DOI：10.1016/s0040-4020(01)86912-x

  日期：1987.1