dibut-3-enyl sulfide | 18022-44-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: dibut-3-enyl sulfide
• 英文别名: Homoallyl sulfide；4-but-3-enylsulfanylbut-1-ene
• CAS: 18022-44-1
• 化学式: C₈H₁₄S
• 分子量: 142.265
• InChiKey: UPPCMVCRFYEIAP-UHFFFAOYSA-N

物化性质

• 沸点：
  78-80 °C
• 密度：
  0.863±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  dibut-3-enyl sulfide 以 盐酸 、 乙醇 、 丙酮 为溶剂， 生成 cis-dibromo(5-thianona-1,8-diene)platinum(II)
  参考文献：
  名称：

  Abel, Edward W.; Evans, David G.; Koe, Julian R., Journal of the Chemical Society, Dalton Transactions, 1989, p. 2315 - 2322

  摘要：

  DOI：
• 作为产物：
  描述：

  4-溴-1-丁烯 在 sodium sulfide 、 乙醇 作用下， 生成 dibut-3-enyl sulfide
  参考文献：
  名称：

  Preparation of Some Unsaturated Sulfonium Halide-Mercuric Halide Double Salts¹

  摘要：

  DOI：

  10.1021/jo01090a014

文献信息

• [EN] BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE À UTILISER EN TANT QU'INHIBITEURS SÉLECTIFS DE PROTÉINE KINASE
  申请人：AB SCIENCE

  公开号：WO2014202763A1

  公开（公告）日：2014-12-24

  The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof. Wherein n, R1, R2, R3, R4, R5, A, Q and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.

  本发明涉及式(I)的化合物或其药用可接受的盐。其中n、R1、R2、R3、R4、R5、A、Q和X如描述中所定义。这些化合物选择性地调节、调控和/或抑制信号传导，该信号传导由涉及多种人类和动物疾病的某些天然和/或突变的蛋白激酶介导，如细胞增殖、代谢、过敏和退行性疾病。更具体地说，这些化合物是有效且选择性的天然和/或突变的c-kit抑制剂。
• [EN] COMPOUNDS WITH ANTI-TUMORAL ACTIVITY<br/>[FR] COMPOSÉS À ACTIVITÉ ANTI-TUMORALE
  申请人：AB SCIENCE

  公开号：WO2016124747A1

  公开（公告）日：2016-08-11

  The present invention relates to compounds of general formula (I), wherein A represents an optionally substituted heterocycle group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy, inhibit, or prevent the growth or spread of cells, especially malignant cells, into surrounding tissues implicated in a variety of human and animal diseases.

  本发明涉及一般式(I)的化合物，其中A代表可选择取代的杂环基团，B代表芳基或杂芳基团，X、R1、R2、R3、R4和R5如描述中所定义。式(I)的化合物可用于破坏、抑制或预防细胞的生长或扩散，特别是恶性细胞，进入与多种人类和动物疾病有关的周围组织。
• [EN] OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT)<br/>[FR] DÉRIVÉS D'OXAZOLE ET DE THIAZOLE COMME INHIBITEURS SÉLECTIFS DE PROTÉINES KINASES (C-KIT)
  申请人：AB SCIENCE

  公开号：WO2013014170A1

  公开（公告）日：2013-01-31

  The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, A, Q, W and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.

  本发明涉及公式I的化合物或其药用盐：其中R1、R2、R3、A、Q、W和X如描述中所定义。这些化合物选择性地调节、调控和/或抑制由某些与多种人类和动物疾病有关的天然和/或突变的蛋白激酶介导的信号传导，如细胞增殖、代谢、过敏和退行性疾病。更具体地说，这些化合物是强效且选择性的天然和/或突变的c-kit抑制剂。
• [EN] DIAZASPIROALKANEONE-SUBSTITUTED OXAZOLE DERIVATIVES AS SPLEEN TYROSINE KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'OXAZOLE À SUBSTITUANT DIAZASPIROALCANONE EN TANT QU'INHIBITEURS DE LA TYROSINE KINASE SPLÉNIQUE
  申请人：AB SCIENCE

  公开号：WO2015144614A1

  公开（公告）日：2015-10-01

  The present invention is concerned with diazaspiroalkanone- substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, autoimmune, allergic, and degenerative disorders. In particular, the presently disclosed compounds are Syk inhibitors.

  本发明涉及替代噻唑衍生物的二氮杂螺环戊酮，能够选择性地调节、调控和/或抑制由某些与多种人类和动物疾病相关的天然和/或突变的蛋白激酶介导的信号传导，例如细胞增殖、代谢、自身免疫、过敏和退行性疾病。特别是，目前披露的化合物是Syk抑制剂。
• NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK
  申请人：AB Science

  公开号：EP3144307A1

  公开（公告）日：2017-03-22

  The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, autoimmune, allergic, hematological, inflammatory and degenerative disorders. In particular, the compounds of the invention are Syk inhibitors. The invention also relates to a process for manufacturing the compounds of the invention.

  本发明涉及替代噁唑衍生物，能选择性地调节、调控和/或抑制由某些涉及人类和动物疾病的特定天然和/或突变蛋白激酶介导的信号转导，如细胞增殖、代谢、自身免疫、过敏、血液学、炎症和退行性疾病。具体来说，本发明的化合物是Syk抑制剂。本发明还涉及一种制造本发明化合物的方法。