2-[2-(4-硝基苯氧基)乙基硫烷基]苯胺 | 919285-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[2-(4-硝基苯氧基)乙基硫烷基]苯胺
• 英文名称: 2-[2-(4-Nitro-phenoxy)-ethylsulfanyl]-phenylamine
• 英文别名: 2-{[2-(4-Nitrophenoxy)ethyl]sulfanyl}aniline；2-[2-(4-nitrophenoxy)ethylsulfanyl]aniline
• CAS: 919285-38-4
• 化学式: C₁₄H₁₄N₂O₃S
• 分子量: 290.343
• InChiKey: UAEPTZLBJMAENK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[2-(4-硝基苯氧基)乙基硫烷基]苯胺 在 盐酸 、 铁粉 作用下， 反应 3.0h， 以70%的产率得到2-[2-(4-氨基苯氧基)乙基硫烷基]苯胺
  参考文献：
  名称：

  Synthesis and study of anti-inflammatory activity of some novel cyclophane amides

  摘要：

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.124
• 作为产物：
  描述：

  1-(2-溴乙氧基)-4-硝基苯 、 2-氨基苯硫醇 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 生成 2-[2-(4-硝基苯氧基)乙基硫烷基]苯胺
  参考文献：
  名称：

  Synthesis and study of anti-inflammatory activity of some novel cyclophane amides

  摘要：

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.124

文献信息

• Synthesis and study of anti-inflammatory activity of some novel cyclophane amides
  作者：Perumal Rajakumar、A. Mohammed Abdul Rasheed、A. Iman Rabia、D. Chamundeeswari

  DOI：10.1016/j.bmcl.2006.08.124

  日期：2006.12

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.