3-Amino-6-butylmercapto-pyridazin | 90154-29-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-Amino-6-butylmercapto-pyridazin
• 英文别名: 6-Butylsulfanylpyridazin-3-amine；6-butylsulfanylpyridazin-3-amine
• CAS: 90154-29-3
• 化学式: C₈H₁₃N₃S
• 分子量: 183.277
• InChiKey: MNMGEBZVGALQJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Amino-6-butylmercapto-pyridazin 、 2-溴-4'-(三氟甲基)苯乙酮 在 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 6-Butylsulfanyl-2-[4-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine
  参考文献：
  名称：

  2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

  摘要：

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.096
• 作为产物：
  描述：

  3-氨基-6-氯哒嗪 、 丁硫醇 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 20.0h， 以50%的产率得到3-Amino-6-butylmercapto-pyridazin
  参考文献：
  名称：

  Design, Synthesis, and Bioactivity Study of Novel Benzoylpyridazyl Ureas

  摘要：

  A series of novel benzoylpyridazyl ureas were designed and synthesized from maleic anhydride and hydrazine monohydrate. These benzoylureas were identified by H-1 NMR spectroscopy and element analysis. The bioactivities of the new compounds were evaluated. These compounds exhibited larvicidal activities against oriental armyworm, and in particular, compound 13 displayed comparable activity to the commercial insecticide Hexaflumuron. Most of these compounds also had some larvicidal activities against mosquito. Interestingly, some compounds showed good plant growth regulatory activities.

  DOI：

  10.1021/jf900882c

文献信息

• Design, Synthesis, and Bioactivity Study of Novel Benzoylpyridazyl Ureas
  作者：Ranfeng Sun、Yonglin Zhang、Fuchun Bi、Qingmin Wang

  DOI：10.1021/jf900882c

  日期：2009.7.22

  A series of novel benzoylpyridazyl ureas were designed and synthesized from maleic anhydride and hydrazine monohydrate. These benzoylureas were identified by H-1 NMR spectroscopy and element analysis. The bioactivities of the new compounds were evaluated. These compounds exhibited larvicidal activities against oriental armyworm, and in particular, compound 13 displayed comparable activity to the commercial insecticide Hexaflumuron. Most of these compounds also had some larvicidal activities against mosquito. Interestingly, some compounds showed good plant growth regulatory activities.
• BE579291
  申请人：——

  公开号：——

  公开（公告）日：——
• 2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus
  作者：Abdelselam Ali、Teresa Cablewski、Craig L. Francis、Ashit K. Ganguly、Roger M. Sargent、David G. Sawutz、Kevin N. Winzenberg

  DOI：10.1016/j.bmcl.2011.05.096

  日期：2011.7

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.