4-chlorostyryltrimethylsilane | 132536-25-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chlorostyryltrimethylsilane
• 英文别名: 2-(4-Chlorophenyl)ethenyl-trimethylsilane
• CAS: 132536-25-5
• 化学式: C₁₁H₁₅ClSi
• 分子量: 210.779
• InChiKey: HRQUJULEIUHYIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.23
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4-碘苯甲醚 、 4-chlorostyryltrimethylsilane 在 bis(dibenzylideneacetone)-palladium⁽⁰⁾ potassium fluoride 、 四丁基氯化铵 、 potassium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 1-氯-4-[2-(4-甲氧基苯基)乙烯基]苯
  参考文献：
  名称：

  One-pot palladium-catalyzed highly chemo-, regio-, and stereoselective synthesis of trans-stilbene derivatives. A concise and convenient synthesis of resveratrol

  摘要：

  A convenient, efficient and highly chemo-, regio-, and stereoselective one-flask synthetic method is reported for the construction of unsymmetrical (or symmetrical) trans-stilbene derivatives based on two sequential Heck-type reactions using tetraalkylammonium salt-based catalyst systems and vinyltrimethylsilane as double bond equivalent. Resveratrol has thus been concisely synthesized. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02317-1
• 作为产物：
  描述：

  对氯碘苯 、 乙烯基三甲基硅烷 在 bis(dibenzylideneacetone)-palladium⁽⁰⁾ potassium fluoride 、 四丁基氯化铵 作用下， 以 甲苯 为溶剂， 生成 4-chlorostyryltrimethylsilane
  参考文献：
  名称：

  One-pot palladium-catalyzed highly chemo-, regio-, and stereoselective synthesis of trans-stilbene derivatives. A concise and convenient synthesis of resveratrol

  摘要：

  A convenient, efficient and highly chemo-, regio-, and stereoselective one-flask synthetic method is reported for the construction of unsymmetrical (or symmetrical) trans-stilbene derivatives based on two sequential Heck-type reactions using tetraalkylammonium salt-based catalyst systems and vinyltrimethylsilane as double bond equivalent. Resveratrol has thus been concisely synthesized. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02317-1

文献信息

• Rapid and efficient entry to vinyl silanes from aldehydes employing a novel metalation–Peterson sequence
  作者：James McNulty、Priyabrata Das

  DOI：10.1039/b716897g

  日期：——

  Bis(trimethylsilyl)chloromethane undergoes a rapid and selective metalation with s-BuLi, yielding the nucleophilic bis(trimethylsilyl)methyl anion and providing a straightforward general entry to vinyl silanes from aromatic, aliphatic and vinyl aldehydes.

  双（三甲基甲硅烷基）氯甲烷与s-BuLi进行快速选择性的金属化反应，生成亲核性双（三甲基甲硅烷基）甲基阴离子，并提供了从芳族，脂肪族和乙烯基醛类直接进入乙烯基硅烷的一般方法。
• Aoyama, Toyohiko; Toyama, Sachio; Tamaki, Naoko, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 8, p. 2957 - 2959
  作者：Aoyama, Toyohiko、Toyama, Sachio、Tamaki, Naoko、Shioiri, Takayuki

  DOI：——

  日期：——