4-dimethylaminomethylstyrene-3-boronic acid | 81992-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-dimethylaminomethylstyrene-3-boronic acid
• 英文别名: 5-vinyl-2-dimethylaminomethylbenzeneboronic acid；[2-[(Dimethylamino)methyl]-5-ethenylphenyl]boronic acid
• CAS: 81992-40-7
• 化学式: C₁₁H₁₆BNO₂
• 分子量: 205.065
• InChiKey: PKZAIONDFOXGNU-UHFFFAOYSA-N

物化性质

• 沸点：
  357.9±52.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.07
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  频哪醇 、 4-dimethylaminomethylstyrene-3-boronic acid 在 molecular sieve 作用下， 以 二氯甲烷 为溶剂， 以65%的产率得到4'-Ethenyl-4,4,5,5,8',8'-hexamethylspiro[1,3-dioxa-2-boranuidacyclopentane-2,7'-8-azonia-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]
  参考文献：
  名称：

  Polymeric Monosaccharide Receptors Responsive at Neutral pH

  摘要：

  We present the first detailed report of the synthesis of Wulff-type styrenic monomers and their polymerization by radical addition-fragmentation chain transfer (RAFT) methods. The resulting polymers and block copolymers exhibit sugar-responsive solubilization in aqueous buffer solutions (pH = 7.4-7.8) in the presence of monosaccharides such as D-fructose and D-glucose.

  DOI：

  10.1021/ja905652w
• 作为产物：
  描述：

  3-bromo-4-dimethylaminomethyl styrene 在 magnesium 、 硼酸三丁酯 作用下， 以 四氢呋喃 为溶剂， 反应 11.25h， 以72%的产率得到4-dimethylaminomethylstyrene-3-boronic acid
  参考文献：
  名称：

  Polymeric Monosaccharide Receptors Responsive at Neutral pH

  摘要：

  We present the first detailed report of the synthesis of Wulff-type styrenic monomers and their polymerization by radical addition-fragmentation chain transfer (RAFT) methods. The resulting polymers and block copolymers exhibit sugar-responsive solubilization in aqueous buffer solutions (pH = 7.4-7.8) in the presence of monosaccharides such as D-fructose and D-glucose.

  DOI：

  10.1021/ja905652w

文献信息

• Polymeric Monosaccharide Receptors Responsive at Neutral pH
  作者：Kyoung Taek Kim、Jeroen J. L. M. Cornelissen、Roeland J. M. Nolte、Jan C. M. van Hest

  DOI：10.1021/ja905652w

  日期：2009.10.7

  We present the first detailed report of the synthesis of Wulff-type styrenic monomers and their polymerization by radical addition-fragmentation chain transfer (RAFT) methods. The resulting polymers and block copolymers exhibit sugar-responsive solubilization in aqueous buffer solutions (pH = 7.4-7.8) in the presence of monosaccharides such as D-fructose and D-glucose.