N,N'-bis(2-hydroxyethyl)succindiamide | 1871-90-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-bis(2-hydroxyethyl)succindiamide
• 英文别名: N1,N4-bis(2-hydroxyethyl)butanediamide；N,N'-bis-(2-hydroxy-ethyl)-succinamide；Bernsteinsaeure-bis-(2-hydroxy-aethylamid)；N,N'-Bis-(2-hydroxy-aethyl)-succinamid；N,N'-bis-(2-hydroxyethyl)-succinic acid diamide；N,N'-bis(2-hydroxyethyl)succinamide；N,N'-bis(2-hydroxyethyl)butanediamide
• CAS: 1871-90-5
• 化学式: C₈H₁₆N₂O₄
• mdl: MFCD00545081
• 分子量: 204.226
• InChiKey: PDECHAVKIJHTRQ-UHFFFAOYSA-N

物化性质

• 熔点：
  156-157 °C
• 沸点：
  601.0±50.0 °C(Predicted)
• 密度：
  1.219±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-bis(2-hydroxyethyl)succindiamide 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 Bernsteinsaeure-di-<2-chlor-ethylamid>
  参考文献：
  名称：

  Kazlauskas,D.A.; Bal'site,E.B., Journal of Organic Chemistry USSR (English Translation), 1972, vol. 8, p. 2338 - 2343

  摘要：

  DOI：
• 作为产物：
  描述：

  C.I.酸性橙108 、 丁二酸二甲酯 生成 N,N'-bis(2-hydroxyethyl)succindiamide
  参考文献：
  名称：

  Kazlauskas,D.A.; Bal'site,E.B., Journal of Organic Chemistry USSR (English Translation), 1972, vol. 8, p. 2338 - 2343

  摘要：

  DOI：

文献信息

• Synthesis and antiischemic activity of dicarboxylic nitroxyalkylamides and nitroxyalkylimides
  作者：B. S. Fedorov、G. N. Bogdanov、M. A. Fadeev、G. V. Lagodzinskaya

  DOI：10.1007/s11172-014-0558-y

  日期：2014.5

  A number of dicarboxylic N-(2-nitroxyalkyl)amides and N-(2-nitroxyalkyl)imides were synthesized and their antiischemic activity was studied. The ratio of the areas of necrotic and ischemic zones was used as a criterion for evaluation of antiischemic activity. The maximum values were close to antiischemic activity of Nicorandil, with acute toxicity of compounds synthesized being considerably lower.

  合成了一系列二羧酸N-(2-硝基烷基)酰胺和N-(2-硝基烷基)酰亚胺，并研究了它们的抗缺血活性。以坏死区和缺血区的面积比作为评估抗缺血活性的标准。最大值接近尼可地尔的抗缺血活性，而合成化合物的急性毒性明显较低。
• Catalyst-free amino-alcoholysis depolymerization strategy: a facile and powerful tool for chemical recycling of poly(bisphenol A carbonate)
  作者：Xianyue Zhou、Maoqing Chai、Guangqiang Xu、Rulin Yang、Hongguang Sun、Qinggang Wang

  DOI：10.1039/d2gc03568e

  日期：——

  The chemical upcycling of poly(bisphenol A carbonate) (BPA-PC) by a catalyst-free amino-alcoholysis depolymerization protocol was achieved.

  使用无催化剂的氨基醇解聚方法，对聚碳酸双酚A（BPA-PC）进行了化学升级回收。
• Use of N-acyl derivatives of aminoalcohols with polycarboxylic acids for the manufacture of a medicament for the treatment of pathologies relating to mast cells
  申请人：LIFEGROUP S.p.A.

  公开号：EP0550008A2

  公开（公告）日：1993-07-07

  N-acyl derivatives of aminoalcohols with polycarboxylic acids able to modulate the degranulation process consequent to the mast cells activation in inflammatory processes caused by overmaximal stimuli of neurogenic and immunogenic origin.

  含有多羧酸的氨基醇 N-酰基衍生物能够调节神经源性和免疫源性过量刺激引起的炎症过程中肥大细胞活化所导致的脱颗粒过程。
• PROCESS FOR THE PRODUCTION OF POLYESTER BLOCK COPOLYMERS, POLYESTER BLOCK COPOLYMER COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF
  申请人：DAICEL CHEMICAL INDUSTRIES, Ltd.

  公开号：EP1120432A1

  公开（公告）日：2001-08-01

  The present invention I relates to a method for the preparation of a polyester block copolymer (P1) characterized in that in the method for the preparation of 100% by weight of the polyester block copolymer (P1) by allowing to react A% by weight of a crystalline aromatic polyester with B% by weight of lactones (A+B=100), (B+0.5)% by weight of lactones are added into A% by weight of a crystalline aromatic polyester, and not less than 0.5% by weight of unreacted lactones are remained with respect to 100% by weight of the polyester block copolymer (P1) after reaction. The present invention II relates to a method for the preparation of a polyester block copolymer (P'1) having a high molecular weight characterized in that the polyester block copolymer (P1) is allowed to further react in a solid phase. The present invention III relates to a polyester block copolymer composition (R) obtained by thermally-processing a polyester block copolymer composition (Q) obtained by melt-mixing 100 parts by weight of a polyester block copolymer (P) with 0.1-5 parts by weight of an epoxy compound (C) having one or more epoxy groups under an inert gas atmosphere and not less than 120°C in a solid phase, and further, at a temperature lower than a melting point of the polyester block copolymer composition (R). The present invention IV relates to a polyester block copolymer composition which comprises thermally-kneading 0.5-5.0 parts by weight of a mono or morefunctional epoxy compound (C) and 0.01-3.0 parts by weight of a complex-formable agent for a metal (G) such as an oxalic acid derivative and a salicylic acid derivative or a hydrazide derivative with 100 parts by weight of a polyester block copolymer (P1) obtained by a reaction of a crystalline aromatic polyester (A1) with lactones (B). The present invention V relates to a polyester block copolymer composition which comprises, in obtaining the polyester block copolymer composition by allowing to react the crystalline aromatic polyester (A1) with lactones (B), adding and thermally-kneading 0.5-5.0 parts by weight of an epoxy compound (C) having one or more pieces of epoxy groups (including at least 0.2 part by weight of two or more functional epoxy compound) and, optionally, 0-2.0 parts by weight of a carbodiimide compound (E) to 100 parts by weight of a polyester block copolymer (P3) obtained by allowing to react 0.1-100% by mol of at least one of a multifunctional compound (D) having at least three pieces of at least one kind of carboxylic group (i), hydroxyl group (ii), and/or an ester-formable group therefrom (iii) with 100% by mol of a crystalline aromatic polyester (A1). The present invention VI relates to a polyester block copolymer composition which comprises, in obtaining said polyester block copolymer composition by allowing to react the crystalline aromatic polyester (A1) with lactones (B), adding and thermally-kneading 0.1-5.0 parts by weight of an epoxy compound (C) having one or more pieces of epoxy groups and 0-2.0 parts by weight of a carbodiimide compound (E) to 100 parts by weight of a polyester block copolymer (P3) obtained by allowing to react 0.1-200% by mol of at least one of an aliphatic or aromatic multifunctional compound (D) having at least three pieces of carboxylic group (i), hydroxyl group (ii), and/or an ester-formable group therefrom (iii) with 100% by mol of a crystalline aromatic polyester (A1). The present invention VII relates to a polyester block copolymer composition (R) which comprises, in obtaining the polyester block copolymer composition by allowing to react the crystalline aromatic polyester (A1) with lactones (B), heating a polyester block copolymer composition (Q) at a solid phase, and the composition (Q) is obtained by adding and thermally-kneading 0.1-5.0 parts by weight of at least one kind of an epoxy compound (C) having one or more pieces of epoxy groups to 100 parts by weight of a polyester block copolymer (P) obtained by allowing to react 0.1-200% by mol of at least one of a multifunctional compound (D) having at least three pieces of carboxylic group (i), hydroxyl group (ii), and/or an ester-formable group therefrom (iii) with 100% by mol of a crystalline aromatic polyester (A1).

  本发明I涉及一种聚酯嵌段共聚物(P1)的制备方法，其特征在于，在通过使A%(重量)的结晶芳香族聚酯与B%(重量)的内酯(A+B=100)反应制备100%(重量)的聚酯嵌段共聚物(P1)的方法中，(B+0.5)%(重量)的内酯加入到A%(重量)的结晶芳香族聚酯中，反应后，相对于100%(重量)的聚酯嵌段共聚物(P1)，未反应的内酯的剩余量不少于0.5%(重量)。 本发明 II 涉及一种具有高分子量的聚酯嵌段共聚物（P'1）的制备方法，其特征在于使聚酯嵌段共聚物（P1）在固相中进一步反应。 本发明 III 涉及一种聚酯嵌段共聚物组合物（R），其制备方法是在惰性气体环境下，将 100 份（重量）聚酯嵌段共聚物（P）与 0.1-5 份（重量）具有一个或多个环氧基团的环氧化合物（C）熔融混合，在不低于 120℃的固相条件下，进一步在低于聚酯嵌段共聚物组合物（R）熔点的温度下，对聚酯嵌段共聚物组合物（Q）进行热加工。 本发明 IV 涉及一种聚酯嵌段共聚物组合物，它包括将 0.5-5.0 份（重量）单官能团环氧 化合物（C）和 0.01-3.0 份（重量）金属络合剂（G），如草酸衍生物和水杨酸衍生物或酰肼衍 生物，与 100 份（重量）由结晶芳香族聚酯（A1）与内酯（B）反应得到的聚酯嵌段共聚物 （P1）进行热捏和。 本发明V涉及一种聚酯嵌段共聚物组合物，其包括在通过使结晶芳香族聚酯(A1)与内酯(B)反应而获得聚酯嵌段共聚物组合物时，加入并热捏和0.5-5.0份(重量)具有一个或多个环氧基团的环氧化合物(C)(包括至少0.2份(重量)两个或多个官能环氧化合物)，以及可选地加入0-2.0份(重量)的碳化二亚胺化合物(E)与100份(重量)的聚酯嵌段共聚物(P3)反应，该聚酯嵌段共聚物(P3)是通过使0.1-100％(摩尔)的至少一种多功能化合物(D)与100％(摩尔)的结晶芳香族聚酯(A1)反应而得到的，该多功能化合物(D)具有至少三种至少一种羧基(i)、羟基(ii)和/或可形成酯的基团(iii)。 本发明 VI 涉及一种聚酯嵌段共聚物组合物，该组合物包括在通过使结晶芳香族聚酯 (A1) 与内酯 (B) 反应而获得所述聚酯嵌段共聚物组合物时，加入并热捏和 0.1-5.0 份（重量份）具有一个或多个环氧基团的环氧化合物 (C) 和 0-2.0份(重量)碳二亚胺化合物(E)与100份(重量)聚酯嵌段共聚物(P3)反应，该聚酯嵌段共聚物(P3)是通过使0.1-200%(摩尔)脂肪族或芳香族多功能化合物(D)中至少一种具有至少三个羧基(Ⅰ)、羟基(Ⅱ)和/或可形成酯的基团(Ⅲ)的化合物与100%(摩尔)结晶芳香族聚酯(A1)反应而得到的。 本发明 VII 涉及一种聚酯嵌段共聚物组合物 (R)，它包括在通过使结晶芳香族聚酯 (A1) 与内酯 (B) 反应而获得聚酯嵌段共聚物组合物时，在固相加热聚酯嵌段共聚物组合物 (Q)，组合物 (Q) 是通过加入并热捏合 0.1-5.在100份重量的聚酯嵌段共聚物(P)中加入0.1-200%(摩尔)的至少一种具有一个或多个环氧基团的环氧化合物(C)，使其与100%(摩尔)的结晶芳香族聚酯(A1)反应，得到聚酯嵌段共聚物(P)。
• Method for the preparation of a polyester block copolymer, a polyester block copolymer composition and method for the preparation thereof
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP1498442A2

  公开（公告）日：2005-01-19

  The first aspect of the present invention, referred to as "present invention III", relates to a polyester block copolymer composition (R) obtained by thermally-processing a polyester block copolymer composition (Q) obtained by melt-mixing 100 parts by weight of a polyester block copolymer (P) with 0.1-5 parts by weight of an epoxy compound (C) having one or more epoxy groups under an inert gas atmosphere and not less than 120°C in a solid phase, and further, at a temperature lower than a melting point of the polyester block copolymer composition (R). The second aspect of the present invention, referred to as "present invention IV", relates to a polyester block copolymer composition which comprises thermally-kneading 0.5-5.0 parts by weight of a mono or morefunctional epoxy compound (C) and 0.01-3.0 parts by weight of a complex-formable agent for a metal (G) such as an oxalic acid derivative and a salicylic acid derivative or a hydrazide derivative with 100 parts by weight of a polyester block copolymer (P1) obtained by a reaction of a crystalline aromatic polyester (A1) with lactones (B). The third aspect of the present invention, referred to as "present invention V", relates to a polyester block copolymer composition which comprises, in obtaining the polyester block copolymer composition by allowing to react the crystalline aromatic polyester (A1) with lactones (B), adding and thermally-kneading 0.5-5.0 parts by weight of an epoxy compound (C) having one or more pieces of epoxy groups (including at least 0.2 part by weight of two or more functional epoxy compound) and, optionally, 0-2.0 parts by weight of a carbodiimide compound (E) to 100 parts by weight of a polyester block copolymer (P3) obtained by allowing to react 0.1-100% by mol of at least one of a multifunctional compound (D) having at least three pieces of at least one kind of carboxylic group (i), hydroxyl group (ii), and/or an ester-formable group therefrom (iii) with 100% by mol of a crystalline aromatic polyester (A1). The fourth aspect of the present invention, referred to as "present invention VI", relates to a polyester block copolymer composition which comprises, in obtaining said polyester block copolymer composition by allowing to react the crystalline aromatic polyester (A1) with lactones (B), adding and thermally-kneading 0.1-5.0 parts by weight of an epoxy compound (C) having one or more pieces of epoxy groups and 0-2.0 parts by weight of a carbodiimide compound (E) to 100 parts by weight of a polyester block copolymer (P3) obtained by allowing to react 0.1-200% by mol of at least one of an aliphatic or aromatic multifunctional compound (D) having at least three pieces of carboxylic group (i), hydroxyl group (ii), and/or an ester-formable group therefrom (iii) with 100% by mol of a crystalline aromatic polyester (A1). The fifth aspect of the present invention, referred to as "present invention VII", relates to a polyester block copolymer composition (R) which comprises, in obtaining the polyester block copolymer composition by allowing to react the crystalline aromatic polyester (A1) with lactones (B), heating a polyester block copolymer composition (Q) at a solid phase, and the composition (Q) is obtained by adding and thermally-kneading 0.1-5.0 parts by weight of at least one kind of an epoxy compound (C) having one or more pieces of epoxy groups to 100 parts by weight of a polyester block copolymer (P) obtained by allowing to react 0.1-200% by mol of at least one of a multifunctional compound (D) having at least three pieces of carboxylic group (i), hydroxyl group (ii), and/or an ester-formable group therefrom (iii) with 100% by mol of a crystalline aromatic polyester (A1).

  本发明的第一方面，称为 "本发明III"，涉及一种聚酯嵌段共聚物组合物（R），该组合物（R）是在惰性气体环境下，将100份（重量）聚酯嵌段共聚物（P）与0.1-5份（重量）具有一个或多个环氧基团的环氧化合物（C）在不低于120℃的固相条件下熔融混合，并在低于聚酯嵌段共聚物组合物（R）熔点的温度下进行热加工而得到的。 本发明的第二方面，称为 "本发明 IV"，涉及一种聚酯嵌段共聚物组合物，它包括热捏合 0.5-5.0 份（重量）单官能团或多官能团环氧化合物 (C) 和 0.01-3.0份(重量)的金属络合剂(G)，如草酸衍生物和水杨酸衍生物或酰肼衍生物，与100份(重量)的由结晶芳香族聚酯(A1)与内酯(B)反应得到的聚酯嵌段共聚物(P1)。 本发明的第三方面，称为 "本发明 V"，涉及一种聚酯嵌段共聚物组合物，其包括在通过使结晶芳香族聚酯（A1）与内酯（B）反应而获得聚酯嵌段共聚物组合物时，加入并热捏和 0.5-5.0 份（重量）具有一个或多个环氧基团的环氧化合物（C）（包括至少 0.2份(重量)的两种或两种以上官能环氧化合物)和可选的0-2.0份(重量)的碳化二亚胺化合物(E)加入到100份(重量)的聚酯嵌段共聚物(P3)中，聚酯嵌段共聚物(P3)是通过使0.1-100%(摩尔)的多功能化合物(D)中的至少一种化合物(D)与100%(摩尔)的结晶芳香族聚酯(A1)反应，该化合物(D)具有至少三种至少一种羧基(i)、羟基(ii)和/或可形成酯的基团(iii)。 本发明的第四个方面，称为 "本发明 VI"，涉及一种聚酯嵌段共聚物组合物，其包括在通过使结晶芳香族聚酯（A1）与内酯（B）反应而获得所述聚酯嵌段共聚物组合物时，加入并热捏和 0.1-5.0 份（重量份）具有一个或多个环氧基团的环氧化合物（C）和 0-2.0份(重量)碳二亚胺化合物(E)到100份(重量)聚酯嵌段共聚物(P3)中，该聚酯嵌段共聚物(P3)是通过使0.1-200％(摩尔)脂肪族或芳香族多功能化合物(D)中至少一种具有至少三个羧基(Ⅰ)、羟基(Ⅱ)和/或可形成酯的基团(Ⅲ)的化合物与100％(摩尔)结晶芳香族聚酯(A1)反应而得到的。 本发明的第五个方面，称为 "本发明 VII"，涉及一种聚酯嵌段共聚物组合物（R），其包括在通过使结晶芳香族聚酯（A1）与内酯（B）反应而获得聚酯嵌段共聚物组合物时，加热固相的聚酯嵌段共聚物组合物（Q），组合物（Q）是通过加入并热捏合 0.1-5.在100份重量的聚酯嵌段共聚物(P)中加入0.1-200%(摩尔)的至少一种具有一个或多个环氧基团的环氧化合物(C)，使其与100%(摩尔)的结晶芳香族聚酯(A1)反应，得到聚酯嵌段共聚物(P)。