ethyl vinyl phthalate | 46492-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl vinyl phthalate
• 英文别名: phthalic acid ethyl ester-vinyl ester；Phthalsaeure-aethylester-vinylester；2-O-ethenyl 1-O-ethyl benzene-1,2-dicarboxylate
• CAS: 46492-28-8
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: SUDCMMPSHKYMMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻苯二甲酸单乙酯 在 zinc(II) oxide 作用下， 生成 ethyl vinyl phthalate
  参考文献：
  名称：

  Vinyl esters of carboxylic acids and their production

  摘要：

  公开号：

  US02066075A1

文献信息

• Improvements in or relating to filled polymeric compositions, hydrated alumina fillers therefor and processes for the production thereof
  申请人：RAYCHEM LIMITED

  公开号：EP0031637A2

  公开（公告）日：1981-07-08

  A water stabilised polymeric composition incorporating a hydrated alumina filler, which is characterised by the presence of an effective amount of an antimony v compound. The compositions have a reduced tendency to absorb water and specific compositions find applications as electrical insulation and in the production of dimensionally recoverable articles.

  一种含有水合氧化铝填料的水稳定聚合物组合物，其特点是含有有效量的锑 v 化合物。这种组合物的吸水性较低，可用于电绝缘和生产可恢复尺寸的物品。
• SPRINKLE COMPOSITION OF CINACALCET
  申请人：Sun Pharmaceutical Industries Limited

  公开号：EP3241549A1

  公开（公告）日：2017-11-08

  The present invention relates to a sprinkle composition of cinacalcet which provides a dissolution profile which is comparable to the currently marketed tablet dosage form.

  本发明涉及一种西那卡西特洒剂组合物，其溶解情况与目前市场上销售的片剂剂型相当。
• RALOXIFENE SPRINKLE COMPOSITION
  申请人：Sun Pharmaceutical Industries Limited

  公开号：EP3251661A1

  公开（公告）日：2017-12-06

  The present invention relates to a capsule composition of raloxifene comprising multiparticulates comprising a) a core comprising raloxifene, and b) a taste-masking coating present in amount of from about 0.5% to about 50%w/w based on the core weight.

  本发明涉及一种包含多微粒的雷洛昔芬胶囊组合物，该多微粒包括：a) 包含雷洛昔芬的内核；b) 掩味涂层，其含量为内核重量的约 0.5% 至约 50%w/w。
• Raloxifene sprinkle composition
  申请人：Sun Pharmaceutical Industries, Ltd.

  公开号：US10092522B2

  公开（公告）日：2018-10-09

  The present invention relates to a capsule composition of raloxifene comprising multiparticulates, comprising a) a core comprising raloxifene; and b) a taste-masking coating present in an amount of from about 15% to about 80% w/w based on the total weight of the composition.

  本发明涉及一种包含多微粒的雷洛昔芬胶囊组合物，该组合物包括 a) 包含雷洛昔芬的核心；和 b) 掩味涂层，其含量为组合物总重量的约 15%至约 80%（重量/湿重）。
• Levelling agent and anti-cratering agent
  申请人：——

  公开号：US20040236007A1

  公开（公告）日：2004-11-25

  Use of a polymer as a levelling agent or anti-cratering agent, said polymer comprising at least one fluorinated unit represented by formula 1, (Formula 1) wherein R?1 is a moiety represented by C n?F 2n+1?-(CH 2?) m?-, C n?F 2n?-(CH 2?) m?-, C n?F 2n+1?-(CII 2?) m?-(OCII 2?CIIR?5 ) p?-, C n?F 2n?-(CH 2? m?-(OCH 2?CHR?5 ) p′? C n?F 2n+1?-(CII 2?) m?-X-, AC n?F 2n?-(CII 2?) m?-X- &lgr;C n?F 2n?-(CH 2?) m?-(OCH 2?CHR?5 ) p?-X or AC n?F 2n+1?-(CII 2?) m?-(OCII 2?CIIR?5 ) p?-X-; wherein A=H, Cl, Br, I, a C 1-12? alkyl or a OC 1-12 ?alkyl, wherein 4≦n≦20,0≦m˜≦4 and 0≦p≦20, wherein X is a spacer moiety selected from the group consisting of esters, amides, sulphoamides, mercapto groups, poltyurethane groups and alkyl groups, wherein R?2 , is H, a metal moiety, an (alkyl)ammonium moiety or an alkyl group, C n?F 2n+1?-(CII 2?) m?-, AC n?F 2n?-(CII 2?) m?-C n?F 2n+1?-(CII 2?) m?-(OCII 2?CIIR?5 ) p?-, C n?F 2n?-(CH 2?) m?-(OCH 2?CHR?5 ) p′? C n?F 2n+1?-(CH 2?) m?-X-, C n?F 2n?-(CH 2?) m?-X-, AC n?F 2n?-(CH 2?) m?-(OCH 2?CHR?5 ) p?-X or C n?F 2n+1?-(CH 2?) m?-(OCH 2?CHR?5 ) p?-X-; wherein A=H, Cl, Br, I, C 1-12? alkyl or OC 1-12 alkyl, wherein 4≦n≦20, 0≦m≦4 and 0≦p≦20, wherein X is a spacer moiety selected from the group consisting of esters, amides, sulphoamides, mercapto groups, polyurethane groups and alkyl groups, wherein R?3 and R?4 are independently selected from the group consisting of H, alkyl-groups and phenyl-groups and wherein R?5 is H and/or methyl group. 1

  一种聚合物作为匀染剂或防缩孔剂的用途，所述聚合物包含至少一个由式 1 表示的氟化单元，（式 1 其中 R?1 是由 C n?F 2n+1?-(CH 2?) m?-, C n?F 2n?-（CH 2?) m?-, C n?F 2n+1?-（CII 2?) m?-(OCII 2?CIIR?5 ) p?-, C n?F 2n?-(CH 2&quest； m?-(OCH 2?CHR?5 ) p′?C n?F 2n+1?-(CII 2?) m?-X-, AC n?F 2n?-（CII 2?) m?-X- &lgr;C n?F 2n?-（CH 2?) m?-(OCH 2?CHR?5 ) p?-X 或 AC n?F 2n+1?-(CII 2?) m?-(OCII 2?CIIR?5 ) p?-X-; 其中 A=H, Cl, Br, I, a C 1-12?烷基或 OC 1-12?烷基，其中 4≦n≦20，0≦m˜≦4 和 0≦p≦20，其中 X 是选自由酯、酰胺、磺酰胺、巯基、聚氨酯基团和烷基组成的组的间隔基，其中 R?2 是 H、金属分子、（烷基）铵分子或烷基，C n?F 2n+1?-(CII 2?) m?-，AC n?F 2n?-（CII 2?) m?-C n?F 2n+1?-(CII 2?) m?-(OCII 2?CIIR?5 ) p?-, C n?F 2n?-(CH 2?) m?-(OCH 2?CHR?5 ) p′? C n?F 2n+1?-(CH 2?) m?-X-, C n?F 2n?-(CH 2?) m?-X-, AC n?F 2n?-（CH 2?) m?-(OCH 2?CHR?5 ) p?-X 或 C n?F 2n+1?-(CH 2?) m?-(OCH 2?CHR?5 ) p?-X-; 其中 A=H, Cl, Br, I, C 1-12? 烷基或 OC 1-12 烷基，其中 4≦n≦20、0≦m≦4 和 0≦p≦20，其中 X 是选自由酯、酰胺、磺酰胺、巯基、聚氨酯基团和烷基组成的组的间隔基，其中 R?3 和 R?4 独立选自 H、烷基和苯基组成的组，其中 R?5 是 H 和/或甲基。 1