2-mesityl-3,4,6,7-tetramethylbenzofuran | 139759-74-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-mesityl-3,4,6,7-tetramethylbenzofuran
• 英文别名: 3,4,6,7-tetramethyl-2-(2,4,6-trimethylphenyl)-1-benzofuran
• CAS: 139759-74-3
• 化学式: C₂₁H₂₄O
• 分子量: 292.421
• InChiKey: CGMKOEPFRNFFMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  β-Methyl-α,β-dimesitylethenol 在 tris(1,10-phenanthroline)iron(III) tris(hexafluorophosphate) 作用下， 以 乙腈 为溶剂， 反应 0.08h， 以70%的产率得到2-mesityl-3,4,6,7-tetramethylbenzofuran
  参考文献：
  名称：

  Enol cation radicals in solution. 4. An improved Synthesis of 4,6,7-Trimethylbenzofurans by oxidation of ?-mesityl substituted enols

  摘要：

  An improved syntectic access for the construction of 4,6,7-trimethylbenzofurans (B1-B8) through the one-electron oxidation of mesityl-substituted enols (E1-E8) is presented. The transformation can be accomplished in good to excellent yields by using various oxidants; i.e. tris(1,10-phenanthroline)iron(III) hexafluorophosphate, FeCl3, Ce(NH4)2(NO3)6, Cu(OTf)2/Cu2O or anodic oxidation.

  DOI：

  10.1002/prac.19943360409

文献信息

• Schmittel, Michael; Roeck, Maik, Chemische Berichte, 1992, vol. 125, # 7, p. 1611 - 1620
  作者：Schmittel, Michael、Roeck, Maik

  DOI：——

  日期：——
• Enol cation radicals in solution. 4. An improved Synthesis of 4,6,7-Trimethylbenzofurans by oxidation of ?-mesityl substituted enols
  作者：Maik R�ck、Michael Schmittel

  DOI：10.1002/prac.19943360409

  日期：——

  An improved syntectic access for the construction of 4,6,7-trimethylbenzofurans (B1-B8) through the one-electron oxidation of mesityl-substituted enols (E1-E8) is presented. The transformation can be accomplished in good to excellent yields by using various oxidants; i.e. tris(1,10-phenanthroline)iron(III) hexafluorophosphate, FeCl3, Ce(NH4)2(NO3)6, Cu(OTf)2/Cu2O or anodic oxidation.