Pentafluorophenyl 5-oxohexanoate | 914981-48-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: Pentafluorophenyl 5-oxohexanoate
• 英文别名: (2,3,4,5,6-pentafluorophenyl) 5-oxohexanoate
• CAS: 914981-48-9
• 化学式: C₁₂H₉F₅O₃
• 分子量: 296.194
• InChiKey: ZJHGNPDXZOXDEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  三氟乙酸五氟苯酯 、 5-氧代己酸 、 N,N-二异丙基乙胺 在 Pentafluorophenyl 5-oxohexanoate 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以to give 4.7 g (79%) of yellowish oil的产率得到Pentafluorophenyl 5-oxohexanoate
  参考文献：
  名称：

  Compounds and methods for labeling oligonucleotides

  摘要：

  本发明提供了一种新的寡核苷酸标记方法，可以使用报告基团标记，包括但不限于淬灭剂、荧光染料、生物素、地高辛、肽和蛋白质。此外，本发明还提供了一种检测寡核苷酸杂交的方法。本发明还提供了具有下列一般式的新型偶氮淬灭剂。本发明进一步提供了包含标记寡核苷酸和固体支持物的组合物。本发明还提供了包含本发明至少一种组合物的试剂盒。

  公开号：

  US07605243B2
• 作为试剂：
  描述：

  三氟乙酸五氟苯酯 、 5-氧代己酸 、 N,N-二异丙基乙胺 在 Pentafluorophenyl 5-oxohexanoate 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以to give 4.7 g (79%) of yellowish oil的产率得到Pentafluorophenyl 5-oxohexanoate
  参考文献：
  名称：

  Compounds and methods for labeling oligonucleotides

  摘要：

  本发明提供了一种新的方法，用于标记寡核苷酸，包括但不限于淬灭剂、荧光染料、生物素、地高辛、肽和蛋白质等报告物。此外，本发明还提供了一种检测寡核苷酸杂交的方法。本发明还提供了具有下列一般式的新型偶氮淬灭剂。本发明还提供了包含标记的寡核苷酸和固体支持物的组合物。本发明还提供了包括本发明至少一种组合物的试剂盒。

  公开号：

  US07476735B2

文献信息

• NUCLEIC ACID MONOMERS WITH 2'-CHEMICAL MOIETIES
  申请人：Laikhter Andrei

  公开号：US20070218490A1

  公开（公告）日：2007-09-20

  The invention provides nucleic acid monomers with a 2′-modification that are useful for the incorporation of dyes or blocking groups. The monomers can be incorporated on the 3′-end of a dual labeled probe to inhibit PCR polymerase extension during PCR. The polymerase is inhibited from extending the probe at the 3′-hydroxyl group when the monomer is present; there is no need to add a chemical moiety to the 3′-hydroxyl or remove the 3′-hydroxyl. The monomers can also be incorporated internally or at the 5′-end of the oligonucleotide. A detectable label, such as a fluorescent or quenching dye, can be incorporated on the 2′-position of such monomers.

  该发明提供了具有2'-修饰的核酸单体，可用于染料或阻断基团的引入。这些单体可以被合并到双标记探针的3'-末端，以在PCR过程中抑制PCR聚合酶的延伸。当单体存在时，聚合酶被抑制在3'-羟基团上延伸探针；无需向3'-羟基团添加化学基团或去除3'-羟基团。这些单体也可以在寡核苷酸的内部或5'-末端进行合并。可以在这些单体的2'-位置上合并可检测的标记，如荧光染料或猝灭染料。
• COMPOUNDS AND METHODS FOR LABELING OLIGONUCLEOTIDES
  申请人：Laikhter Andrei

  公开号：US20090118482A1

  公开（公告）日：2009-05-07

  The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.

  本发明提供了一种新的寡核苷酸标记方法，包括但不限于猝灭剂、荧光染料、生物素、地高辛、肽和蛋白质等报告基团。此外，本发明还提供了一种检测寡核苷酸杂交的方法。本发明还提供了具有下列一般式的新的偶氮猝灭剂。本发明还提供了包含标记寡核苷酸和固体支持物的组合物。本发明还提供了至少包含一种本发明组合物的试剂盒。
• US20140343123A1
  申请人：——

  公开号：US20140343123A1

  公开（公告）日：2014-11-20
• COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：US20160090595A1

  公开（公告）日：2016-03-31

  Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoCIII). In certain embodiments, the ApoCIII targeting oligomeric compounds are conjugated to N-Acetylgalactosamine Also disclosed herein are conjugated oligomeric compounds targeting ApoCIII for use in decreasing ApoCIII to treat, prevent, or ameliorate diseases, disorders or conditions related to ApoCIII. Certain diseases, disorders or conditions related to ApoCIII include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
• COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：US20160090596A1

  公开（公告）日：2016-03-31

  Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.