N-(p-toluenesulfonyl)-N'-(o-chlorophenyl)urea | 53855-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(p-toluenesulfonyl)-N'-(o-chlorophenyl)urea
• 英文别名: 1-(2-Chlorophenyl)-3-(4-methylphenyl)-sulfonylurea；1-(2-chlorophenyl)-3-(4-methylphenyl)sulfonylurea
• CAS: 53855-79-1
• 化学式: C₁₄H₁₃ClN₂O₃S
• 分子量: 324.788
• InChiKey: QZJFMJCWOPZNJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2935009090

反应信息

• 作为产物：
  描述：

  Potassium;benzenesulfonyl(chloro)azanide 在 PdCl2(AsPh3)2 作用下， 以 二氯甲烷 为溶剂， 20.0 ℃ 、4.0 MPa 条件下， 生成 N-(p-toluenesulfonyl)-N'-(o-chlorophenyl)urea
  参考文献：
  名称：

  Besenyei, Gabor; Nemeth, Sandor; Simandi, Laszlo J., Angewandte Chemie, 1990, vol. 102, # 10, p. 1168 - 1169

  摘要：

  DOI：

文献信息

• Palladium-catalyzed carbonylation of (arylsulfonyliminoiodo)benzenes to arylsulfonyl isocyanates
  作者：Gábor Besenyei、László I. Simándi

  DOI：10.1016/s0040-4039(00)73576-3

  日期：1993.4

  In the presence of palladium complexes as catalysts, carbonylation of (arylsulfonyliminoiodo)benzenes to arylsulfonyl isocyanates can be accomplished with 50–80% yield.

  在钯络合物作为催化剂的存在下，可以将（芳基磺酰亚胺基碘）苯羰基化为芳基磺酰基异氰酸酯，产率为50-80％。
• Thermosensitive recording material and novel color developer compounds
  申请人：OJI PAPER CO., LTD.

  公开号：EP1264707A2

  公开（公告）日：2002-12-11

  Disclosed is a thermosensitive recording material comprising a sheet-shaped support and a thermosensitive recording layer which is formed on at least one surface of the support and comprises a colorless or light-colored dye precursor and a color developer capable of reacting with the dye precursor and inducing color formation therein upon application of heat thereto, the color developer comprising a compound represented by the following formula (I) or analog thereof:: The thermosensitive recording material has high sensitivity and can prevent white background portions from coloring and recorded images from decolorizing in an environmental resistance test.

  本发明公开了一种热敏记录材料，它包括片状支架和热敏记录层，热敏记录层至少形成在支架的一个表面上，它包括无色或浅色染料前体和显色剂，显色剂能与染料前体发生反应，并在受热时形成颜色，显色剂包括下式(I)或其类似物所代表的化合物：： 热敏记录材料具有高灵敏度，在耐环境测试中可防止白色背景部分着色和记录的图像脱色。
• Thermosensitive recording materials
  申请人：Oji Paper Co., Ltd.

  公开号：EP1512545A1

  公开（公告）日：2005-03-09

  A thermosensitive recording material comprising a substrate sheet and a thermosensitive colored image-forming layer formed on at least one surface of the substrate sheet and comprising at least one colorless or light-colored dye precursor and a color-developing agent reactive with the dye precursor upon heating to thereby develop a color, wherein the color-developing agent comprises at least one compound of the formula (I):    (wherein R1 represents a member selected from the group consisting of unsubstituted aromatic hydrocarbon groups and substituted aromatic hydrocarbon groups with at least one substituent selected from the group consisting of a methyl group and a chlorine atom, and R2 represents a divalent organic group).

  一种热敏记录材料，包括基片和在基片的至少一个表面上形成的热敏彩色图像形成层，该热敏彩色图像形成层包括至少一种无色或浅色染料前体和在加热时与染料前体反应从而显色的显色剂，其中显色剂包括至少一种式(I)化合物： (其中 R1 代表选自由甲基和氯原子组成的组中的未取代的芳香烃基团和具有至少一个选自由甲基和氯原子组成的组中的取代基的取代芳香烃基团的成员，R2 代表二价有机基团）。
• Novel agents effective against solid tumors: the diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships
  作者：J. Jeffry Howbert、C. Sue Grossman、Thomas A. Crowell、Brent J. Rieder、Richard W. Harper、Kenneth E. Kramer、Eddie V. Tao、James Aikins、Gerald A. Poore

  DOI：10.1021/jm00171a013

  日期：1990.9

  A series of diarylsulfonylureas with exceptionally broad-spectrum activity against syngeneic rodent solid tumors in vivo is described. Their discovery resulted from a program dedicated to in vivo screening for novel oncolytics in solid tumor models, rather than traditional ascites leukemia models. The structures, oral efficacy, side-effect profile, and mechanism of action of these sulfonylureas appear to be distinct from previously known classes of oncolytics. An extensive series of analogues was prepared to probe structure-activity relationships (SAR), with particular focus on the substituent patterns of each aryl domain. Quantitative analysis of these substituent SARs, using the method of cluster significance analysis, showed the lipophilicity of the substituents to be the dominant determinant of activity. One compound from the series, LY186641 (104, sulofenur), has progressed to Phase I clinical trials as an antitumor drug.
• Thermosensitive recording material
  申请人：OJI PAPER CO., LTD.

  公开号：EP0604832B1

  公开（公告）日：1998-06-03