10-(N-methylcarbamoyl)-3,7-bis(dimethylamino)-10H-phenothiazine | 102035-56-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 10-(N-methylcarbamoyl)-3,7-bis(dimethylamino)-10H-phenothiazine
• 英文别名: 10H-Phenothiazine-10-carboxamide, 3,7-bis(dimethylamino)-N-methyl-；3,7-bis(dimethylamino)-N-methylphenothiazine-10-carboxamide
• CAS: 102035-56-3
• 化学式: C₁₈H₂₂N₄OS
• 分子量: 342.465
• InChiKey: XEZFKMUDMLXWAW-UHFFFAOYSA-N

物化性质

• 沸点：
  588.2±50.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  10-(N-methylcarbamoyl)-3,7-bis(dimethylamino)-10H-phenothiazine 在 succinate buffer 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 亚甲兰
  参考文献：
  名称：

  Relationships between the Molecular Structures and Stabilities of Functional Dyes with a Phenothiazine Skeleton

  摘要：

  10-N-甲基氨基甲酰基-3,7-双（二甲基氨基）-10H-吩噻嗪（MCDP）是临床上用作诊断的功能性染料之一。MCDP 会自发分解成亚甲基蓝，同时增加诊断的不良背景。了解自发分解的机制对于分子设计更好的功能性染料至关重要。我们对 MCDP 的两种衍生物--10-N-甲基硫代氨基甲酰基-3,7-双（二甲基氨基）-10H-吩噻嗪和 10-N-苄基硫代氨基甲酰基-3,7-双（二甲基氨基）-10H-吩噻嗪进行了 X 射线分析。根据三维结构分析了它们之间的结构-性能关系。

  DOI：

  10.1246/bcsj.69.1423

文献信息

• <i>De Novo</i>Design of Hemoprotein Model with Peroxidase Activity toward Lipophilic Peroxide
  作者：Kin-ya Tomizaki、Hidekazu Nishino、Tamaki Kato、Akira Miike、Norikazu Nishino

  DOI：10.1246/cl.2000.648

  日期：2000.6

  A single-chained 49-mer-polypeptide tethering iron(III)-porphyrin folded into a certain conformation with bis-histidine coordination and consumed favorably linoleic acid hydroperoxide rather than H2O2.

  一种单链的49个氨基酸聚肽连接铁（III）-卟啉，折叠成某种构象，具有双组氨酸配位，优先消耗亚油酸过氧化物而非H2O2。
• METHOD FOR MEASURING TRIGLYCERIDE IN LOW-DENSITY LIPOPROTEIN AND KIT FOR MEASUREMENT
  申请人：Katayama Yuki

  公开号：US20090226944A1

  公开（公告）日：2009-09-10

  The present invention provides a method for a simple and accurate measurement of triglycerides in low-density lipoprotein in a sample comprising performing the following steps sequentially: (i) a step of generating free glycerol by allowing lipoprotein lipase to act on a sample, in an aqueous medium comprising the sample and a specific surfactant such as polyoxyethylene polyoxyalkylene polycyclic phenyl ether; (ii) a step of removing free glycerol present in the reaction solution of the above step (i); (iii) a step of generating free glycerol by allowing lipoprotein lipase to act on the reaction solution from which free glycerol has been removed in step (ii), in the presence of a specific surfactant such as polyoxyethylene polyoxyalkylene alkyl ether; and (iv) a step of measuring free glycerol generated in step (iii), and a kit used for the method.

  本发明提供了一种简单准确地测量样品中低密度脂蛋白中甘油三酯的方法，包括按照以下步骤顺序进行：(i)在包括样品和特定表面活性剂（例如聚氧乙烯聚氧烷基多环苯醚）的水介质中，使脂蛋白酯酶作用于样品，生成游离甘油；(ii)去除步骤(i)中反应溶液中存在的游离甘油；(iii)在去除步骤(ii)中的游离甘油的反应溶液中，使脂蛋白酯酶作用于特定表面活性剂（例如聚氧乙烯聚氧烷基烷基醚）的存在下，生成游离甘油；(iv)测量步骤(iii)中生成的游离甘油，以及用于该方法的试剂盒。
• METHOD OF QUANTITATING CHOLESTEROL IN LOW-DENSITY LIPOPROTEIN
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP0763741A1

  公开（公告）日：1997-03-19

  The present invention relates to a method for the determination of cholesterol in low-density lipoprotein (LDL) in a sample containing LDL, which comprises eliminating cholesterol in high-density lipoprotein in the sample, subjecting the sample to a reaction utilizing the action of a cholesterol ester-hydrolyzing enzyme and the action of a cholesterol-oxidizing enzyme or of cholesterol oxidoreductase, and determining the amount of hydrogen peroxide or a reduced type coenzyme generated by the reaction.

  本发明涉及一种测定含有低密度脂蛋白（LDL）的样品中低密度脂蛋白（LDL）中胆固醇的方法，该方法包括消除样品中高密度脂蛋白中的胆固醇、将样品置于利用胆固醇酯水解酶和胆固醇氧化酶或胆固醇氧化还原酶作用的反应中，并测定反应生成的过氧化氢或还原型辅酶的量。
• METHOD OF QUANTIFYING CHOLESTEROL IN LOW-DENSITY OR VERY-LOW-DENSITY LIPOPROTEIN
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP0764848A1

  公开（公告）日：1997-03-26

  The present invention relates to a method for determination of cholesterol in low-density lipoprotein (LDL) or very low-density lipoprotein (VLDL) in a sample, which comprises determining the amount of cholesterol in LDL or VLDL in the sample in the presence of a sugar compound and/or a protein solubilizing agent.

  本发明涉及一种测定样品中低密度脂蛋白（LDL）或极低密度脂蛋白（VLDL）中胆固醇含量的方法，该方法包括在糖类化合物和/或蛋白质增溶剂的存在下测定样品中低密度脂蛋白或极低密度脂蛋白中的胆固醇含量。
• Method for storing liquid diagnostic reagents
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP0786663A1

  公开（公告）日：1997-07-30

  Disclosed is a method for stably storing a liquid diagnostic reagent, comprising air-hermetically keeping the liquid diagnostic reagent in a closed container in the presence of a disoxidant therein. Preferably, at least one of the liquid diagnostic reagent and the disoxidant is covered with a separating container made of a material pervious to oxygen but not to solutions. The liquid diagnostic reagent may comprise an enzyme or an indicator.

  本发明公开了一种稳定贮存液体诊断试剂的方法，该方法包括将液体诊断试剂在密闭容器中进行气热保存，其中存在一种二氧化剂。液体诊断试剂和脱氧剂中的至少一种最好用一个由透氧但不透溶液的材料制成的分离容器覆盖。液体诊断试剂可包括酶或指示剂。