(R)-α-(methoxymethyl)benzeneethanamine | 59919-07-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-α-(methoxymethyl)benzeneethanamine
• 英文别名: (R)-1-methoxy-3-phenylpropan-2-amine；(R)-1-Benzyl-2-methoxyaethylamin；(2R)-1-methoxy-3-phenylpropan-2-amine
• CAS: 59919-07-2
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: FAZIHZPDHJBQKN-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-α-(methoxymethyl)benzeneethanamine 在 rhodium on alumina 氢气 作用下， 以 乙醇 为溶剂， 生成 (R)-(+)-1-Methoxy-2-amino-3-cyclohexylpropan
  参考文献：
  名称：

  Asymmetric synthesis of (+)- or (-)-2-methyloctanal via the metalloenamines of chiral alkoxy amines

  摘要：

  DOI：

  10.1021/jo00399a021

文献信息

• Mild Esterification of Carboxylic Acids via Continuous Flow Diazotization of Amines
  作者：Clément Audubert、Hélène Lebel

  DOI：10.1021/acs.orglett.7b02231

  日期：2017.8.18

  A new continuous flow protocol for the diazotization of methylamine with 1,3-propanedinitrite in THF is reported. The synthesis of methyl esters was achieved in high yields from a variety of carboxylic acids in 20 min at 90 °C. Additionally, this protocol was extended to other aryl and alkyl amines, namely secondary amines, to produce various substituted esters in high yield using 2-MeTHF as a solvent

  报道了一种新的连续流方案，用于在THF中将甲胺与1,3-丙炔重氮化。在90°C下20分钟内可以从多种羧酸中高收率地合成甲酯。另外，该方案扩展到其他芳基和烷基胺，即仲胺，以使用2-MeTHF作为溶剂以高收率生产各种取代的酯。反应条件与许多官能团相容，即含氮杂环，炔烃，烯烃，醇和酚。机理研究表明，反应似乎是通过瞬态重氮物质而不是重氮中间体进行的。
• Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners
  申请人：CASTRO C. Alfredo

  公开号：US20080114167A1

  公开（公告）日：2008-05-15

  The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

  该发明涉及含有结合到Bcl蛋白并抑制Bcl功能的异氧杂环丙氨酸化合物。这些化合物可用于治疗和调节与过度增殖相关的疾病，如癌症。
• Parallel synthesis of 2-alkoxy and 2-acyloxyphenylpropyl amides and amines using dihydrocoumarins as versatile synthons. Application of a novel resin quench-capture method
  作者：Jacqueline C. Bussolari、Diana C. Rehborn、Donald W. Combs

  DOI：10.1016/s0040-4039(98)02598-2

  日期：1999.2

  preparation of libraries of 2-substituted phenylpropyl amines and amides was accomplished using dihydrocoumarins as a useful synthon in parallel synthesis. Resin quench methods were utilized in the purifications of the amides and a resin quench-capture method was utilized in metallo-organic reductions leading to the targeted phenylpropyl amines.

  使用二氢香豆素作为平行合成中的有用合成子，完成了溶液相合成，用于制备2-取代的苯基丙胺和酰胺的文库。在酰胺的纯化中使用树脂淬灭方法，在金属有机还原中使用树脂淬灭捕获方法，得到目标苯丙胺。
• BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS
  申请人：Harris Joel M.

  公开号：US20110065671A1

  公开（公告）日：2011-03-17

  The present invention relates to Bicyclic Heterocycle Derivatives of formula (I), compositions comprising a Bi-cyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR1 19 in a patient.

  本发明涉及式(I)的二环杂环衍生物，包括一种二环杂环衍生物的组合物，并且还涉及使用这些二环杂环衍生物来治疗或预防患者的肥胖症、糖尿病、代谢障碍、心血管疾病或与GPR1 19活性相关的疾病的方法。
• Asymmetric alkylation of acyclic ketones via chiral metallo enamines. Effect of kinetic vs. thermodynamic metalations.
  作者：A. I. Meyers、Donald R. Williams

  DOI：10.1021/jo00410a034

  日期：1978.8