3-methyl-N-phenyl-fumaramic acid | 10490-14-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-N-phenyl-fumaramic acid
• 英文别名: 3-Methyl-N-phenyl-fumaramidsaeure；Mesaconsaeure-β-anilid；Mesacon-β-anilsaeure；N-Phenyl-citraconamidsaeure；3-Methyl-3-phenylcarbamoyl-acrylic acid；4-anilino-3-methyl-4-oxobut-2-enoic acid
• CAS: 10490-14-9
• 化学式: C₁₁H₁₁NO₃
• 分子量: 205.213
• InChiKey: VAJPJRSEWCFQPT-UHFFFAOYSA-N

物化性质

• 沸点：
  443.3±37.0 °C(Predicted)
• 密度：
  1.281±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methyl-N-phenyl-fumaramic acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 中康酸 、 苯胺
  参考文献：
  名称：

  Anschuetz; Haas; Sieplein, Justus Liebigs Annalen der Chemie, 1907, vol. 353, p. 179

  摘要：

  DOI：
• 作为产物：
  描述：

  3-methyl-N-phenyl-fumaramic acid methyl ester 在 氢氧化钾 作用下， 生成 3-methyl-N-phenyl-fumaramic acid
  参考文献：
  名称：

  Anschuetz; Haas; Sieplein, Justus Liebigs Annalen der Chemie, 1907, vol. 353, p. 179

  摘要：

  DOI：

文献信息

• Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors
  申请人：Topo Target ApS

  公开号：US20030032625A1

  公开（公告）日：2003-02-13

  Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison.

  Maleimide和succinimide衍生物被发现是有效的拓扑异构酶II催化抑制剂。由于这种特性，对maleimide和succinimide衍生物进行了研究，以评估它们作为细胞静止剂并在癌症治疗中的应用。该发明的化合物可与其他细胞静止剂（如拓扑异构酶II毒素）联合治疗。由于其有效的拓扑异构酶II催化抑制活性，maleimide和succinimide衍生物还可用作逸出剂，例如在给予拓扑异构酶II毒素后。
• SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS
  申请人：Jensen Buhl Peter

  公开号：US20070196360A1

  公开（公告）日：2007-08-23

  Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison.

  Maleimide和succinimide衍生物被发现是有效的拓扑异构酶II催化抑制剂。由于这种特性，研究了maleimide和succinimide衍生物作为细胞静止剂的用途，因此用于癌症的治疗。该发明的化合物可以与其他细胞静止剂，如拓扑异构酶II毒素，组合使用。由于其有效的拓扑异构酶II催化抑制活性，maleimide和succinimide衍生物也可用作外渗剂，例如在给予拓扑异构酶II毒素时。
• Formation and stability of amide and imide links
  作者：T. V. Sheremeteva、V. A. Gusinskaya

  DOI：10.1007/bf00845946

  日期：1966.4
• [EN] SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS<br/>[FR] DERIVES DE SUCCINIMIDE ET DE MALEIMIDE ET LEUR UTILISATION COMME INHIBITEURS CATALYTIQUES DE LA TOPOISOMERASE II
  申请人：TOPO TARGET APS

  公开号：WO2002078679A2

  公开（公告）日：2002-10-10

  Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison. Formula (I), wherein -J- is selected from the group consisting of (A) and (B). A compound of formula (II) for use as medicament. A compound of formula (III).
• Anschuetz; Haas; Sieplein, Justus Liebigs Annalen der Chemie, 1907, vol. 353, p. 179
  作者：Anschuetz、Haas、Sieplein

  DOI：——

  日期：——