4-methyl-2-(2-methylbut-3-en-2-yl)phenol | 1221426-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-2-(2-methylbut-3-en-2-yl)phenol
• 英文别名: 4-Methyl-2-(2-methylbut-3-en-2-yl)phenol
• CAS: 1221426-22-7
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: ARPMQHLTXZUHAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-methyl-2-(2-methylbut-3-en-2-yl)phenol 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以66%的产率得到tert-butyldimethyl(4-methyl-2-(2-methylbut-3-en-2-yl)phenoxy)silane
  参考文献：
  名称：

  De novo synthesis of teleocidin B analogs

  摘要：

  Teleocidin B analogs have been synthesized in 24 steps and 1.9% overall yield. The key steps include aromatic Claisen rearrangement, intramolecular Heck reaction of a tetra-substituted alkene, and ruthenium (II) catalyzed indole cyclization. Teleocidin and the new analogs promote cell spreading on fibroblast cells that were treated with amino-Nogo, an inhibitor of cell spreading. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.01.048
• 作为产物：
  描述：

  Acetic acid 2-(1,1-dimethyl-allyl)-4-methyl-phenyl ester 在 potassium hydroxide 、 水 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以0.18 g的产率得到4-methyl-2-(2-methylbut-3-en-2-yl)phenol
  参考文献：
  名称：

  De novo synthesis of teleocidin B analogs

  摘要：

  Teleocidin B analogs have been synthesized in 24 steps and 1.9% overall yield. The key steps include aromatic Claisen rearrangement, intramolecular Heck reaction of a tetra-substituted alkene, and ruthenium (II) catalyzed indole cyclization. Teleocidin and the new analogs promote cell spreading on fibroblast cells that were treated with amino-Nogo, an inhibitor of cell spreading. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.01.048

文献信息

• Prenylation of 4-Methylphenol
  作者：I. Yu. Chukicheva、I. V. Fedorova、Т. А. Kolegova、A.V. Kutchin

  DOI：10.1134/s1070363220030032

  日期：2020.3

  AbstractOrganoaluminum (aluminum phenolate and aluminum isopropylate) and acidic heterogeneous catalysts (zeolites C-10, C-100 and ZSM, clay KSF, sulfonic cation exchangers Fiban K-1 and Amberlist 36 Dry) were studied in the alkylation of 4-methylphenol with prenol. Effective catalysts and conditions for the synthesis of 4-methyl-2-prenylphenol, 2,6-diprenyl-4-methylphenol, and chromane were revealed

  摘要研究了有机铝（苯酚铝和异丙醇铝）和酸性多相催化剂（沸石C-10，C-100和ZSM，粘土KSF，磺酸阳离子交换剂Fiban K-1和Amberlist 36 Dry）在4-甲基苯酚与泼尼醇的烷基化反应中的作用。 。揭示了合成4-甲基-2-异戊烯基苯酚，2,6-二异戊烯基-4-甲基苯酚和苯并二氢丙烷的有效催化剂和条件。
• De novo synthesis of teleocidin B analogs
  作者：Jun Pu、Kangwen Deng、John Butera、Michael Chlenov、Adam Gilbert、Mike Kagan、James Mattes、Lynn Resnick

  DOI：10.1016/j.tet.2010.01.048

  日期：2010.3

  Teleocidin B analogs have been synthesized in 24 steps and 1.9% overall yield. The key steps include aromatic Claisen rearrangement, intramolecular Heck reaction of a tetra-substituted alkene, and ruthenium (II) catalyzed indole cyclization. Teleocidin and the new analogs promote cell spreading on fibroblast cells that were treated with amino-Nogo, an inhibitor of cell spreading. (C) 2010 Elsevier Ltd. All rights reserved.