4-nitro-N-[2-(piperazin-1-yl)ethyl]phthalimide | 358767-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4-nitro-N-[2-(piperazin-1-yl)ethyl]phthalimide
• 英文别名: 5-Nitro-2-(2-piperazin-1-ylethyl)isoindole-1,3-dione
• CAS: 358767-78-9
• 化学式: C₁₄H₁₆N₄O₄
• 分子量: 304.305
• InChiKey: TYYHZQHCCXYBJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  98.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-nitro-N-[2-(piperazin-1-yl)ethyl]phthalimide 在 palladium on activated charcoal 、 lead dioxide 氧气 、 ammonium formate 、 potassium carbonate 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 4.17h， 生成
  参考文献：
  名称：

  SYNTHESIS AND STUDY OF DOUBLE (EPR ACTIVE AND FLUORESCENT) CHEMOSENSORS IN THE PRESENCE OF Fe³⁺ION

  摘要：

  The fluorescence properties of 4-aminophthalimide derivatives are influenced by the side-chain attached to the paramagnetic ring or its diamagnetic precursor. PET (photo-induced electron transfer)-induced fluorescence enhancement in the presence of Fe3+ ions was observed only in the case of diamagnetic basic side chain derivatives, since transient metal ions are present in biological systems, only double sensors lacking the above sensitivity are considered as potential reactive oxygen probes.

  DOI：

  10.1081/scc-100103525
• 作为产物：
  描述：

  N-氨乙基哌嗪 、 4-硝基邻苯二甲酰亚胺 以78%的产率得到4-nitro-N-[2-(piperazin-1-yl)ethyl]phthalimide
  参考文献：
  名称：

  SYNTHESIS AND STUDY OF DOUBLE (EPR ACTIVE AND FLUORESCENT) CHEMOSENSORS IN THE PRESENCE OF Fe³⁺ION

  摘要：

  The fluorescence properties of 4-aminophthalimide derivatives are influenced by the side-chain attached to the paramagnetic ring or its diamagnetic precursor. PET (photo-induced electron transfer)-induced fluorescence enhancement in the presence of Fe3+ ions was observed only in the case of diamagnetic basic side chain derivatives, since transient metal ions are present in biological systems, only double sensors lacking the above sensitivity are considered as potential reactive oxygen probes.

  DOI：

  10.1081/scc-100103525

文献信息

• SYNTHESIS AND STUDY OF DOUBLE (EPR ACTIVE AND FLUORESCENT) CHEMOSENSORS IN THE PRESENCE OF Fe³⁺ION
  作者：Olga H. Hankovszky、Tamás Kálai、Éva Hideg、József Jekö、Kálmán Hideg

  DOI：10.1081/scc-100103525

  日期：2001.1

  The fluorescence properties of 4-aminophthalimide derivatives are influenced by the side-chain attached to the paramagnetic ring or its diamagnetic precursor. PET (photo-induced electron transfer)-induced fluorescence enhancement in the presence of Fe3+ ions was observed only in the case of diamagnetic basic side chain derivatives, since transient metal ions are present in biological systems, only double sensors lacking the above sensitivity are considered as potential reactive oxygen probes.