methyl 2-(3-aminophenyl)furan-3-carboxylate | 445307-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: methyl 2-(3-aminophenyl)furan-3-carboxylate
• 英文别名: 2-(3-Aminophenyl)furan-3-carboxylic Acid Methyl Ester
• CAS: 445307-39-1
• 化学式: C₁₂H₁₁NO₃
• 分子量: 217.224
• InChiKey: AMNGOSWPHVUAFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-(3-aminophenyl)furan-3-carboxylate 在 盐酸 、 lithium hydroxide 、 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 为溶剂， 生成 2-[3-[[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]amino]phenyl]furan-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing heterobiaryl carboxylic acids

  摘要：

  The design, synthesis, and SAR of a novel series of heterobiaryl phenethanolamine beta(3) adrenergic receptor agonists are described. The furan analogue 49 was shown to elicit a significant dose-dependent lowering of plasma glucose in a rodent model of type 2 diabetes. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.069
• 作为产物：
  描述：

  3-糠酸 在 palladium on activated charcoal 盐酸 、 硫酸 、 氢气 、 sodium nitrite 作用下， 以 甲醇 为溶剂， 生成 methyl 2-(3-aminophenyl)furan-3-carboxylate
  参考文献：
  名称：

  Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing heterobiaryl carboxylic acids

  摘要：

  The design, synthesis, and SAR of a novel series of heterobiaryl phenethanolamine beta(3) adrenergic receptor agonists are described. The furan analogue 49 was shown to elicit a significant dose-dependent lowering of plasma glucose in a rodent model of type 2 diabetes. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.069

文献信息

• Chemical compounds
  申请人：——

  公开号：US20040106672A1

  公开（公告）日：2004-06-03

  The present invention discloses compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the compounds of formula I, in particular methods for treating diabetes or obesity.

  本发明揭示了I式化合物。本发明还揭示了I式β-3激动剂以及使用I式化合物治疗β-3介导的疾病和病状的方法，特别是治疗糖尿病或肥胖症的方法。
• Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors
  申请人：SmithKline Beecham Corporation

  公开号：US07034053B2

  公开（公告）日：2006-04-25

  The present invention disclosed compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the compounds of formula I, in particular methods for treating diabetes or obesity.

  本发明揭示了式I的化合物。本发明还揭示了式I的β-3激动剂以及使用式I化合物治疗β-3介导的疾病和病况的方法，特别是治疗糖尿病或肥胖症的方法。
• CHEMICAL COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1366033B1

  公开（公告）日：2005-04-27
• US7034053B2
  申请人：——

  公开号：US7034053B2

  公开（公告）日：2006-04-25
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：GLAXO GROUP LTD

  公开号：WO2002060885A1

  公开（公告）日：2002-08-08

  The present invention discloses compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the compounds of formula I, in particular methods for treating diabetes or obesity.