1-methyl-4-[(E)-2-phenylethenoxy]benzene | 32546-88-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methyl-4-[(E)-2-phenylethenoxy]benzene
• CAS: 32546-88-6
• 化学式: C₁₅H₁₄O
• 分子量: 210.276
• InChiKey: PTQJYMAKVCHCGG-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对甲酚 、 [(Z)-2-溴乙烯基]苯 在 copper(l) iodide 、 caesium carbonate 、 2-环己酮甲酸乙酯 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 以89%的产率得到1-methyl-4-[(E)-2-phenylethenoxy]benzene
  参考文献：
  名称：

  Mild Copper(I) Iodide/β-Keto Ester Catalyzed Coupling Reactions of Styryl Bromides with Phenols, Thiophenols, and Imidazoles

  摘要：

  报道了一种高效且温和的O、S和N亲核试剂的乙烯化反应。使用碘化铜(I)/乙基2-氧代环己烷羧酸酯作为催化体系。该方法对底物上的广泛功能基团具有良好的耐受性，并能够中等至优良产率生成相应的芳基斯蒂尔醚、芳基斯蒂尔硫化物和N-斯蒂尔咪唑，且具有良好的立体选择性。

  DOI：

  10.1055/s-2008-1067082

文献信息

• Reaction of Benzyne with Styrene Oxide: Insertion of Arynes into a C-O Bond of Epoxides
  作者：Diego Peña、Sandra Beltrán-Rodil、Enrique Guitián

  DOI：10.1055/s-2007-977460

  日期：——

  Benzyne inserts into one of the C-O bonds of styrene -oxide to form a dihydrobenzofuran as the major product together with five other reaction products. A detailed study of the reaction mixture clarified an intriguing forty-year-old personal communication from Stiles and Haag.

  Benzyne 插入到氧化苯乙烯的 CO 键之一中，与其他五种反应产物一起形成二氢苯并呋喃作为主要产物。对反应混合物的详细研究澄清了来自 Stiles 和 Haag 的有趣的 40 年前个人交流。
• Methods and compositions for the treatment of amyloid-and epileptogenesis-associated diseases
  申请人：Kong Xianqi

  公开号：US20050038000A1

  公开（公告）日：2005-02-17

  Methods of treating or preventing an amyloid-related disease in a subject by administering to a subject a therapeutic amount of a compound of the invention are described. Also included are methods for inhibiting epileptogenesis in a subject, by administering to a subject an effective amount of an anti-epileptogenic agent. Methods for treating a subject suffering from an epileptogenesis-associated condition, by administering to the subject an effective amount of an anti-epileptogenic agent are also included. Methods for treating convulsions in a subject by administering to the subject an effective amount of a therapeutic amount of a compound of the invention are also described.

  本文描述了通过向患者施用本发明化合物的治疗量来治疗或预防与淀粉样疾病有关的疾病的方法。还包括通过向患者施用抗癫痫剂的有效剂量来抑制癫痫发生的方法。本文还包括通过向患有癫痫发生相关疾病的患者施用抗癫痫剂的有效剂量来治疗患者的方法。本文还描述了通过向患者施用本发明化合物的治疗量的有效剂量来治疗患者的惊厥的方法。
• Nickel-photoredox-catalyzed E- and Z-stereoconvergent coupling of alkenyl halides and phenols
  作者：Sodai Nishino、Takuya Kurahashi

  DOI：10.1093/chemle/upae111

  日期：2024.6.1

  Herein, we report a Ni-photoredox-catalyzed stereoconvergent coupling of phenols and alkenyl halides, which affords a Z-coupling product. Moreover, by simply changing the solvent, the reaction also provides access to the E-coupling product with high stereoselectivity. The key factor for changing the stereoisomer of the product was found to be the fluorescence lifetime of photocatalyst.

  在此，我们报道了一种Ni-光氧化还原催化的苯酚和卤代烯的立体会聚偶联，它提供了Z-偶联产物。此外，通过简单地改变溶剂，该反应还提供了具有高立体选择性的E-偶联产物。研究发现改变产物立体异构体的关键因素是光催化剂的荧光寿命。
• TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES
  申请人：Neurochem (International) Limited

  公开号：EP1635909A2

  公开（公告）日：2006-03-22
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES<br/>[FR] PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES ASSOCIEES AU PEPTIDE AMYLOIDE ET A L'EPILEPTOGENESE
  申请人：NEUROCHEM INT LTD

  公开号：WO2005000406A2

  公开（公告）日：2005-01-06

  Methods of treating or preventing an amyloid-related disease in a subject by administering to a subject a therapeutic amount of a compound of the invention are described. Also included are methods for inhibiting epileptogenesis in a subject, by administering to a subject an effective amount of an anti-epileptogenic agent. Methods for treating a subject suffering from an epileptogenesis-associated condition, by administering to the subject an effective amount of an anti-epileptogenic agent are also included. Methods for treating convulsions in a subject by administering to the subject an effective amount of a therapeutic amount of a compound of the invention are also described.