(R,R)-(+)-N-(1-(1-naphthyl)ethyl)-5-hydroxyhexanamide | 483287-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R,R)-(+)-N-(1-(1-naphthyl)ethyl)-5-hydroxyhexanamide
• 英文别名: (5R)-5-hydroxy-N-[(1R)-1-naphthalen-1-ylethyl]hexanamide
• CAS: 483287-62-3
• 化学式: C₁₈H₂₃NO₂
• 分子量: 285.386
• InChiKey: MABHANMBSBYQTR-ZIAGYGMSSA-N

物化性质

• 沸点：
  518.1±43.0 °C(Predicted)
• 密度：
  1.097±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R,R)-(+)-N-(1-(1-naphthyl)ethyl)-5-hydroxyhexanamide 在 盐酸 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 1,5-R-己烷二醇
  参考文献：
  名称：

  Optical Resolution of 5-Alkyl-δ-Valerolactones and Synthesis of Optically Active 5-Fluoroalkanols

  摘要：

  Optical resolutions of 5-alkyl-delta-valerolactones were carried out by derivatization to the diastereomeric amides, in which (R)-(+)1-(1-naphthyl)ethylamine or (S)-(-)-1-phenylethylamine were used as resolving agents. Optically active 5-fluoroalkanols, useful intermediates for fluorinated ferroelectric liquid crystals, were derived from the resolved lactones in four steps without racemization.

  DOI：

  10.1080/10242430210707
• 作为产物：
  描述：

  (R)-1-(1-萘基)乙胺 、 丁位己内酯 以 苯 为溶剂， 生成 (R,R)-(+)-N-(1-(1-naphthyl)ethyl)-5-hydroxyhexanamide
  参考文献：
  名称：

  Optical Resolution of 5-Alkyl-δ-Valerolactones and Synthesis of Optically Active 5-Fluoroalkanols

  摘要：

  Optical resolutions of 5-alkyl-delta-valerolactones were carried out by derivatization to the diastereomeric amides, in which (R)-(+)1-(1-naphthyl)ethylamine or (S)-(-)-1-phenylethylamine were used as resolving agents. Optically active 5-fluoroalkanols, useful intermediates for fluorinated ferroelectric liquid crystals, were derived from the resolved lactones in four steps without racemization.

  DOI：

  10.1080/10242430210707

文献信息

• Optical Resolution of 5-Alkyl-δ-Valerolactones and Synthesis of Optically Active 5-Fluoroalkanols
  作者：Asep Riswoko、Yoshio Aoki、Takuji Hirose、Hiroyuki Nohira

  DOI：10.1080/10242430210707

  日期：2002.1

  Optical resolutions of 5-alkyl-delta-valerolactones were carried out by derivatization to the diastereomeric amides, in which (R)-(+)1-(1-naphthyl)ethylamine or (S)-(-)-1-phenylethylamine were used as resolving agents. Optically active 5-fluoroalkanols, useful intermediates for fluorinated ferroelectric liquid crystals, were derived from the resolved lactones in four steps without racemization.