N-(3-azetidinylmethyl)ethanamine | 91188-18-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: N-(3-azetidinylmethyl)ethanamine
• 英文别名: N-(azetidin-3-ylmethyl)ethanamine
• CAS: 91188-18-0
• 化学式: C₆H₁₄N₂
• 分子量: 114.19
• InChiKey: VGAMVQMWRXDPQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(diphenylmethyl)-N-ethyl-3-azetidinemethanamine 生成 N-(3-azetidinylmethyl)ethanamine
  参考文献：
  名称：

  CULBERTSON, TOWNLEY P.;DOMA, JOHN M.;MICH, THOMAS F.;NICHOLS, JEFFREY B.

  摘要：

  DOI：

文献信息

• [EN] HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROARYLES SERVANT D'INHIBITEURS D'IRAK, ET LEURS UTILISATIONS
  申请人：MERCK PATENT GMBH

  公开号：WO2016081679A1

  公开（公告）日：2016-05-26

  The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, useful as IRAK inhibitors.

  本发明涉及式I化合物或其药用可接受盐，用作IRAK抑制剂。
• [EN] IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF<br/>[FR] IMMUNOMODULATEURS, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：BETTA PHARMACEUTICALS CO LTD

  公开号：WO2020156323A1

  公开（公告）日：2020-08-06

  Provided herein are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

  本文提供了一种化合物的公式（I），以及使用这些化合物作为免疫调节剂的方法，以及包含这些化合物的药物组合物。这些化合物可用于治疗、预防或改善癌症或感染等疾病或疾病。
• Thieno-and furo-pyrimidine modulators of the histamine H4 receptor
  申请人：Edwards James P.

  公开号：US20090075970A1

  公开（公告）日：2009-03-19

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  描述了噻吩-和呋喃-嘧啶化合物，这些化合物可用作H4受体调节剂。这些化合物可以用于制药组合物和用于调节组胺H4受体活性以及治疗由H4受体活性介导的疾病状态、紊乱和条件的方法，如炎症。
• THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Edwards James P.

  公开号：US20120214792A1

  公开（公告）日：2012-08-23

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  本文描述了噻吩和呋喃嘧啶化合物，可用作H4受体调节剂。这些化合物可用于制备药物组合物和方法，以调节组胺H4受体活性，并用于治疗由H4受体活性介导的疾病状态、障碍和病情，例如炎症。
• THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Edwards James P.

  公开号：US20120238544A1

  公开（公告）日：2012-09-20

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  本文描述了一种噻吩和呋喃嘧啶化合物，可用作H4受体调节剂。这些化合物可以用于制备药物组合物和方法，用于调节组胺H4受体活性，以及治疗由H4受体活性介导的疾病状态，疾病和病情，如炎症。