2-丙炔-1-基1-吡咯烷羧酸酯 | 123477-57-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 2-丙炔-1-基1-吡咯烷羧酸酯
• 英文名称: Pyrrolidine-1-carboxylic acid prop-2-ynyl ester
• 英文别名: Prop-2-yn-1-yl pyrrolidine-1-carboxylate；prop-2-ynyl pyrrolidine-1-carboxylate
• CAS: 123477-57-6
• 化学式: C₈H₁₁NO₂
• mdl: MFCD03200938
• 分子量: 153.181
• InChiKey: JRTVUTADKUCKKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-丙炔-1-基1-吡咯烷羧酸酯 在 benzyltriethylammonium tetrathiomolybdate 作用下， 以 乙腈 为溶剂， 反应 2.5h， 以97%的产率得到四氢吡咯
  参考文献：
  名称：

  A mild and selective method for N-dealkylation of tertiary amines

  摘要：

  Alkyl groups can be cleaved efficiently and selectively from tertiary alkyl amines using propargyl chloroformate. The propargyloxycarbonyl (Poc) protected secondary amines thus obtained can be deblocked under neutral and mild conditions using benzyltriethylammonium tetrathiomolybdate. The generality and compatibility of the method have been studied with a wide range of functionalities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.018
• 作为产物：
  描述：

  1-苄基-吡咯烷 、 炔丙基氯甲酸酯 以 氯仿 为溶剂， 反应 0.2h， 以90%的产率得到2-丙炔-1-基1-吡咯烷羧酸酯
  参考文献：
  名称：

  A mild and selective method for N-dealkylation of tertiary amines

  摘要：

  Alkyl groups can be cleaved efficiently and selectively from tertiary alkyl amines using propargyl chloroformate. The propargyloxycarbonyl (Poc) protected secondary amines thus obtained can be deblocked under neutral and mild conditions using benzyltriethylammonium tetrathiomolybdate. The generality and compatibility of the method have been studied with a wide range of functionalities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.018

文献信息

• Pyrrolopyridines useful as inhibitors of protein kinase
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2354140A1

  公开（公告）日：2011-08-10

  The present invention relates to compounds of formula (I) wherein Q, Z, R1, R2, and R3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及式(I)化合物，其中Q、Z、R1、R2和R3如权利要求1所述，可用作蛋白激酶，特别是JAK家族和ROCK家族激酶的抑制剂。本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病、病症或失调的方法。
• Non-aqueous electrolyte solution additive, and non-aqueous electrolyte solution for lithium secondary battery and lithium secondary battery which include the same
  申请人：LG Chem, Ltd.

  公开号：US11081729B2

  公开（公告）日：2021-08-03

  The present invention relates to a non-aqueous electrolyte solution additive, and a non-aqueous electrolyte solution for a lithium-ion battery and a lithium-ion battery which include the same, and particularly, to a non-aqueous electrolyte solution, which may remove an acid generated by the decomposition of a lithium salt while being able to suppress the dissolution of metal impurities causing failure in the battery by using and including a Lewis base compound containing a propargyl group as a non-aqueous electrolyte solution additive for a lithium-ion battery, and a lithium secondary battery in which transition metal dissolution in a positive electrode and a low-voltage phenomenon are improved.

  本发明涉及一种非水电解质溶液添加剂，以及一种用于锂离子电池的非水电解质溶液和一种包含该添加剂的锂离子电池，特别是一种非水电解质溶液、通过使用和包括含有丙炔基团的路易斯碱化合物作为锂离子电池的非水电解质溶液添加剂，可去除锂盐分解产生的酸，同时能够抑制导致电池失效的金属杂质的溶解，以及改善正极中过渡金属溶解和低电压现象的锂二次电池。
• SUZUKI, KUNIO;USHIJIMA, RYOSUKE;MIYANO, TETSUJI;NAKAGAWA, SUSUMU, HETEROCYCLES, 29,(1989) N, C. 497-509
  作者：SUZUKI, KUNIO、USHIJIMA, RYOSUKE、MIYANO, TETSUJI、NAKAGAWA, SUSUMU

  DOI：——

  日期：——
• Non-aqueous Electrolyte Solution Additive, and Non-aqueous Electrolyte Solution for Lithium Secondary Battery and Lithium Secondary Battery which Include the Same
  申请人：LG Chem, Ltd.

  公开号：US20200044287A1

  公开（公告）日：2020-02-06

  The present invention relates to a non-aqueous electrolyte solution additive, and a non-aqueous electrolyte solution for a lithium-ion battery and a lithium-ion battery which include the same, and particularly, to a non-aqueous electrolyte solution, which may remove an acid generated by the decomposition of a lithium salt while being able to suppress the dissolution of metal impurities causing failure in the battery by using and including a Lewis base compound containing a propargyl group as a non-aqueous electrolyte solution additive for a lithium-ion battery, and a lithium secondary battery in which transition metal dissolution in a positive electrode and a low-voltage phenomenon are improved.