2,3',4-Trihydroxy-benzophenon | 837-60-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3',4-Trihydroxy-benzophenon
• 英文别名: (2,4-Dihydroxyphenyl)(3-Hydroxyphenyl)methanone；(2,4-dihydroxyphenyl)-(3-hydroxyphenyl)methanone
• CAS: 837-60-5
• 化学式: C₁₃H₁₀O₄
• 分子量: 230.22
• InChiKey: NBKYIYGREQXQJY-UHFFFAOYSA-N

物化性质

• 熔点：
  178–182°C
• 沸点：
  495.2±28.0 °C(Predicted)
• 密度：
  1.413±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二羟基苯甲酸 、 苯酚 在 zinc(II) chloride 、 三氯氧磷 作用下， 反应 2.5h， 生成 2,3',4-Trihydroxy-benzophenon
  参考文献：
  名称：

  聚羟基二苯甲酮作为 α-葡萄糖苷酶抑制剂的评价

  摘要：

  本实验旨在利用Friedel-Crafts反应合成18种多羟基二苯甲酮，以对硝基苯基-β-D-吡喃半乳糖苷（PNPG）为底物，测定对α-葡萄糖苷酶的抑制活性。在这里，阿卡波糖 (IC50 = 1674.75 µmol L - 1) 用作参考抑制剂。结果表明，大多数目标化合物对α-葡萄糖苷酶具有显着的抑制活性。在所有这些化合物中，2,4,4', 6-butahydroxydiphenylketone (11) 被发现是最有效的 α-葡萄糖苷酶抑制剂，IC50 值为 10.62 µmol L - 1。此外，我们通过动力学分析发现这些化合物是竞争性抑制剂。结果表明，此类化合物可用于开发新的糖尿病治疗候选药物。

  DOI：

  10.1002/ardp.201000147

文献信息

• Radiation-sensitive positive resist composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0461654A2

  公开（公告）日：1991-12-18

  A positive resist composition comprising a radiation-sensitive component, an alkali-soluble resin and a phenol compound of the formula: wherein R is a hydrogen atom, a lower alkyl group or a phenyl group, R' is an alkyl group or an alkoxy group, and n is a number of 0 to 3, which has well balanced good properties such as sensitivity, resolution, heat resistance and adhesiveness.

  一种阳离子抗蚀剂组合物，由辐射敏感成分、碱溶性树脂和式中的苯酚化合物组成： 其中 R 是氢原子、低级烷基或苯基，R'是烷基或烷氧基，n 是 0 至 3 的数字，它具有良好的平衡特性，如敏感性、分辨率、耐热性和粘合性。
• Positive type resist composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0559204A1

  公开（公告）日：1993-09-08

  A positive type resist composition comprising an alkali-soluble resin and a quinonediazide compound, wherein the alkali-soluble resin containing resin (A) is obtainable through a condensation reaction with at least one phenol compound represented by the following general formula (I): wherein R₁ to R₃ independently of one another each represent a hydrogen atom or an alkyl or alkoxy group having 1-4 carbon atoms and k represents 1 or 2, at least one compound represented by the following general formula (II): wherein R₄ represents a hydrogen atom, an alkyl group having 1-4 carbon atoms or a phenyl group, R₅ to R₇ independently of one another each represent a hydrogen atom or an alkyl or alkoxy group having 1-4 carbon atoms and n represents 1 or 2, and an aldehyde compound. This composition is excellent in the balance between performances such as sensitivity, heat resistance and profile, and is free from scum.

  一种由碱溶性树脂和醌噻嗪化合物组成的正型抗蚀剂组合物，其中含有树脂（A）的碱溶性树脂可通过与至少一种由下式通式（I）代表的苯酚化合物发生缩合反应而获得： 其中 R₁至 R₃各自独立地代表氢原子或具有 1-4 个碳原子的烷基或 烷氧基，k 代表 1 或 2： 其中 R₄ 代表氢原子、具有 1-4 个碳原子的烷基或苯基，R₅ 至 R₇ 各自独立地代表氢原子或具有 1-4 个碳原子的烷基或烷氧基，n 代表 1 或 2，以及醛化合物。这种组合物在灵敏度、耐热性和外形等性能之间具有极佳的平衡性，而且不会产生浮渣。
• Synthesis and biological evaluation of polyhydroxy benzophenone as mushroom tyrosinase inhibitors
  作者：Jianlong Wu、Xuesen Hu、Lin Ma

  DOI：10.3109/14756366.2010.521745

  日期：2011.6.1

  A series of polyhydroxy benzophenone were synthesized and evaluated as mushroom tyrosinase inhibitors. The results demonstrated that most of the target compounds had remarkable inhibitory activities on mushroom tyrosinase. Among all these compounds, 2,3,4,3'',4'',5''-hexahydroxy-diphenylketone 10 was found to be the most potent tyrosinase inhibitor with IC50 value of 1.4 mu mu M. In addition, the inhibition kinetics analyzed by Lineweaver--Burk plots revealed that such compounds were competitive inhibitors. These results suggested that such compounds might be utilized for the development of new candidate for treatment of dermatological disorders.
• Positive resist composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0460416B1

  公开（公告）日：1996-08-21
• US5188920A
  申请人：——

  公开号：US5188920A

  公开（公告）日：1993-02-23