1,3-Bis[(2,4-dichlorophenyl)methylideneamino]urea | 6341-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-Bis[(2,4-dichlorophenyl)methylideneamino]urea
• CAS: 6341-79-3
• 化学式: C₁₅H₁₀Cl₄N₄O
• 分子量: 404.083
• InChiKey: AFJFPVJYDDLXJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  碳酰肼 、 2,4-二氯苯甲醛 反应 0.12h， 以93%的产率得到1,3-Bis[(2,4-dichlorophenyl)methylideneamino]urea
  参考文献：
  名称：

  Green Synthetic Method for 1,5‐Disubstituted Carbohydrazones

  摘要：

  A green synthetic method for 1,5-disubstituted carbohydrazones is described. The reaction of dimethyl carbonate with hydrazine hydrate first gave carbohydrazide, which further reacted with various aromatic aldehydes or aliphatic ketones under solvent-free conditions to efficiently afford 1,5-disubstituted carbohydrazone. This protocol has the advantages of using nontoxic dimethyl carbonate as starting material, no use of organic solvents, short reaction time, high yield, and simple workup procedure.

  DOI：

  10.1080/00397910600764600

文献信息

• Green Synthetic Method for 1,5‐Disubstituted Carbohydrazones
  作者：Zheng Li、Wei Zhu、Jinlan Yu、Xuelin Ma、Zhong Lu、Shuxiu Xiao

  DOI：10.1080/00397910600764600

  日期：2006.9

  A green synthetic method for 1,5-disubstituted carbohydrazones is described. The reaction of dimethyl carbonate with hydrazine hydrate first gave carbohydrazide, which further reacted with various aromatic aldehydes or aliphatic ketones under solvent-free conditions to efficiently afford 1,5-disubstituted carbohydrazone. This protocol has the advantages of using nontoxic dimethyl carbonate as starting material, no use of organic solvents, short reaction time, high yield, and simple workup procedure.