Dimethylallyl ammonium chloride | 6877-06-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Dimethylallyl ammonium chloride
• 英文别名: N,N-dimethylallylamine hydrochloride；N,N-dimethylallylammonium chloride；allyldimethylammonium chloride；allyldimethylamine hydrochloride；dimethyl allyl amine hydrochloride；allyldimathylammoniumchlorid；Dimethyl(prop-2-enyl)azanium;chloride；dimethyl(prop-2-enyl)azanium;chloride
• CAS: 6877-06-1
• 化学式: C₅H₁₂N*Cl
• 分子量: 121.61
• InChiKey: LZBIYPIDWSGLOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  3.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  锂硼氢 、 Dimethylallyl ammonium chloride 以 乙醚 为溶剂， 以48%的产率得到N,N-dimethyl allylamine-borane
  参考文献：
  名称：

  Thiele, Karl-Heinz; Kurzhals, Rolf; Duemichen, Ulf, Zeitschrift fur Anorganische und Allgemeine Chemie

  摘要：

  DOI：
• 作为产物：
  描述：

  二甲基烯丙基胺 、 三氯丁烯 以 甲苯 为溶剂， 反应 16.0h， 生成 、 Dimethylallyl ammonium chloride
  参考文献：
  名称：

  Reaction features of 2,3,4-trichloro-1-butene with phosphoric and nitrogen nucleophiles

  摘要：

  Reaction of 2,3,4-trichloro-1-butene with phosphoric and nitrogen nucleophiles was carried out. In the reaction with allyldiphenylphosphine 1,4-bis-(allyldiphenylphosphoniochlorido)-1,3-butadiene was obtained, with tributylphosphine, allyldimethylamine and trimethylamine respective 1,4-bis-onium salts with 2-chloro-2-butenylene group. Reaction with trimethylamine proceeded with formation of monoammonium salt with 3,4-dichloro-2-butenyl group. It is noteworthy that 1,4-splitting of 1,4-bis-(trimethylammoniochlorido)-2-butene at the action of sodium methoxide occurs with involvement of the less labile hydrogen atom.

  DOI：

  10.1134/s1070363208110108

文献信息

• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：GLAXO GROUP LTD

  公开号：WO2012035055A1

  公开（公告）日：2012-03-22

  The invention is directed to certain novel compounds. Specifically, the invention directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Itk activity.

  这项发明涉及某些新颖的化合物。具体地，该发明涉及公式（I）的化合物及其盐。该发明的化合物是激酶活性抑制剂，特别是Itk活性的抑制剂。
• [EN] APP SPECIFIC BACE INHIBITORS (ASBIs) AND USES THEREOF<br/>[FR] INHIBITEURS DE BACE SPÉCIFIQUES DE L'APP (ASBI) ET LEURS UTILISATIONS
  申请人：JOHN VARGHESE

  公开号：WO2013142370A1

  公开（公告）日：2013-09-26

  In certain embodiments APP-specific BACE inhibitors (ASBIs) are provided as well as uses thereof. In certain embodiments methods of preventing or delaying the onset of a pre-Alzheimer's condition and/or cognitive dysfunction, and/or ameliorating one or more symptoms of a pre-Alzheimer's condition and/or cognitive dysfunction, or preventing or delaying the progression of a pre-Alzheimer's condition or cognitive dysfunction to Alzheimer's disease are provided where the method involves administering to a subject in need thereof an APP specific BACE inhibitor (ASBI) in an amount sufficient to prevent or delay the onset of a pre-Alzheimer's cognitive dysfunction, and/or to ameliorate one or more symptoms of a pre-Alzheimer's cognitive dysfunction, and/or to prevent or delay the progression of a pre-Alzheimer's cognitive dysfunction to Alzheimer's disease. In certain embodiments the ASBI is a flavonoid (e.g. galangin) or flavonoid progrug (e.g., galangin prodrug).

  在某些实施例中，提供了特定于APP的BACE抑制剂（ASBI）以及其用途。在某些实施例中，提供了预防或延迟早期阿尔茨海默病症状和/或认知功能障碍的方法，以及改善早期阿尔茨海默病症状和/或认知功能障碍的一种或多种症状，或预防或延迟早期阿尔茨海默病症状或认知功能障碍发展为阿尔茨海默病的方法，其中该方法涉及向需要的受试者施用足以预防或延迟早期阿尔茨海默病认知功能障碍发作的APP特异性BACE抑制剂（ASBI）的剂量，和/或改善早期阿尔茨海默病认知功能障碍的一种或多种症状，和/或预防或延迟早期阿尔茨海默病认知功能障碍发展为阿尔茨海默病。在某些实施例中，ASBI是一种黄酮类化合物（例如，没药酮）或黄酮类化合物前药（例如，没药酮前药）。
• [EN] MTORC MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE MTORC ET LEURS UTILISATIONS
  申请人：AEOVIAN PHARMACEUTICALS INC

  公开号：WO2020154447A1

  公开（公告）日：2020-07-30

  Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.

  本文披露了新型雷帕霉素类似物及其用途。本公开的雷帕霉素类似物相对于雷帕霉素表现出增加的mTORC1特异性和降低的mTORC2特异性。
• Formulations designed to be applied on keratinous material and to be rinsed
  申请人：Anthony Olivier

  公开号：US20060107469A1

  公开（公告）日：2006-05-25

  The invention concerns a formulation designed to be applied on keratinous material such as the skin, the hair, and to be rinsed with an aqueous rinsing medium, in the form of a stable dispersion for a pH ranging between 3 and 5.5, and comprising at least one active substance, a vector agent consisting of at least one organic polymer capable of bringing said active substance to the surface of the keratinous material during the rinsing process, and optionally at least one salt soluble in the formulation; the active substance, whether or not in liquid form, has in the medium of the formulation, a global cationic or zero charge; it is insoluble in the formulation medium and stabilized by means of a cationic surfactant and it remains insoluble or tends to swell in the rinsing medium; the invention also concerns methods for treating keratinous material using said formulation, as well as the use of a vector agent consisting of at least an organic polymer in the formulation as agent capable of bringing the active matter to the surface of the keratinous matter during the rinsing process

  该发明涉及一种配方，旨在涂抹在角质素材料上，如皮肤、头发，并用含水冲洗介质冲洗，形式为稳定分散液，pH值在3至5.5之间，包括至少一种活性物质，一种载体剂，由至少一种有机聚合物组成，能够在冲洗过程中将该活性物质带到角质素材料表面，并且在配方中可溶的至少一种盐；该活性物质，无论是液体形式与否，在配方介质中具有全局阳离子或零电荷；它在配方介质中不溶解，并通过阳离子表面活性剂稳定，并保持不溶解或在冲洗介质中膨胀；该发明还涉及使用该配方处理角质素材料的方法，以及使用至少一种有机聚合物作为载体剂在配方中，作为在冲洗过程中将活性物质带到角质素材料表面的能力。
• Silver dihydrogen citrate compositions
  申请人：Arata B. Andrew

  公开号：US20060051430A1

  公开（公告）日：2006-03-09

  Personal care and home care compositions are disclosed, which include silver dihydrogen citrate. The inventive compositions advantageously take the form of suspensions, pastes, liquids and gels. The inventive compositions also optionally comprise additional ingredients, and are therefore suitable for a wide variety of personal, home and industrial care purposes.

  护理和家居用品组合物被披露，其中包括柠檬酸二氢银。这种创新的组合物有利地采用悬浮液、糊状物、液体和凝胶的形式。这些创新的组合物还可以选择性地包含额外的成分，因此适用于各种个人、家庭和工业护理用途。