ethyl 5-[p-[6-(1-imidazolyl)hexanamido]phenoxy]-2,2-dimethylpentanoate | 95923-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 5-[p-[6-(1-imidazolyl)hexanamido]phenoxy]-2,2-dimethylpentanoate
• 英文别名: ethyl 5-[4-(6-imidazol-1-ylhexanoylamino)phenoxy]-2,2-dimethylpentanoate
• CAS: 95923-63-0
• 化学式: C₂₄H₃₅N₃O₄
• 分子量: 429.56
• InChiKey: GGVMRTBCWCHSGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  82.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4'-hydroxy-6-(1-imidazolyl)hexaneanilide hydrochloride 、 ethyl 2,2-dimethyl-5-bromopentanoate 在 potassium carbonate 作用下， 以 乙醇 、 1,2-二氯乙烷 为溶剂， 生成 ethyl 5-[p-[6-(1-imidazolyl)hexanamido]phenoxy]-2,2-dimethylpentanoate
  参考文献：
  名称：

  Imidazolyl phenoxy compounds and method of use

  摘要：

  咪唑基苯氧衍生物以及含有这种衍生物的药物组合物被提供。这些组合物对于降低受试者的脂质活性有用，因此对于降低胆固醇和甘油三酯有用。

  公开号：

  US04794113A1

文献信息

• Certain thiazol-4-yl-phenoxy derivatives having lipid lowering properties
  申请人：——

  公开号：US04942242A1

  公开（公告）日：1990-07-17

  Thiazolyl phenoxy derivatives are provided as well as pharmaceutical compositions containing such derivatives. The compositions are useful for lowering lipid activity in a subject and accordingly useful for reducing cholesterol and triglycerides.

  提供了噻唑基苯氧衍生物，以及含有这些衍生物的药物组合物。这些组合物对于降低受试者的脂质活性非常有用，因此有助于降低胆固醇和甘油三酯。
• Certain pyridyl or imidazol-1-yl-alkyleneoxy-(or
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04795753A1

  公开（公告）日：1989-01-03

  The present invention relates to novel phenoxy derivatives represented by the formula (I): ##STR1## wherein: A is an imidazolyl group, a pyridyl group, a pyridyloxy group, B is group represented by the formula: --(CH.sub.2).sub.n --O--, --(CH.sub.2).sub.n CONH(CH.sub.2).sub.k -- or --(CH.sub.2).sub.n-N (R.sup.4)-- wherein k is 0 or an integer of 1 to 5, n is an integer of 1 to 6 and R.sup.4 is hydrogen or a lower alkyl group; m is 0 or an integer of 1 to 6; R.sup.1 is a hydroxyl group, an amino group or a lower alkoxy group; R.sup.2 and R.sup.3 which may be the same or different represent, a hydrogen atom or a lower alkyl group hereafter the same, having lipid lowering activity, and salts thereof.

  本发明涉及由公式（I）表示的新的苯氧衍生物：##STR1## 其中：A是咪唑基，吡啶基，吡啶氧基，B是由公式表示的基团：--（CH.sub.2）.sub.n--O--，--（CH.sub.2）.sub.nCONH（CH.sub.2）.sub.k--或--（CH.sub.2）.sub.n-N（R.sup.4）--，其中k为0或1至5的整数，n为1至6的整数，R.sup.4为氢或较低的烷基；m为0或1至6的整数；R.sup.1为羟基，氨基或较低的烷氧基；R.sup.2和R.sup.3可以相同也可以不同，表示氢原子或较低的烷基，具有降脂作用，以及其盐。
• Certain pyridinyl or imidazolinyl-4-thiazolyl-phenoxy alkanoic acid
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04798838A1

  公开（公告）日：1989-01-17

  The present invention relates to novel phenoxy derivatives represented by the formula (I): ##STR1## wherein: A is an imidazolyl group, a pyridyl group, a pyridyloxy group, an oxo-substituted chromenyloxy group, a lower alkyl group, an amino group which may be substituted with a phenyl group or a lower alkyl group, or a carbamoyl group substituted with a cyclohexylamino group or an imidazolylalkyl group; B is a single bond, a thiazolyl group which may be substituted with a lower alkyl group, a group represented by the formula: --(CH.sub.2).sub.n --O--, --(CH.sub.2).sub.n CONH(CH.sub.2).sub.k -- or --(CH.sub.2).sub.n --N(R.sup.4)-- wherein k is 0 or an integer of 1 to 5, n is an integer of 1 to 6 and R.sup.4 is hydrogen or a lower alkyl group; m is 0 or an integer of 1 to 6; R.sup.1 is a hydroxyl group, an amino group or a lower alkoxy group; R.sup.2 and R.sup.3 which may be the same or different, represent a hydrogen atom or a lower alkyl group hereafter the same: and salts thereof. In the definition of the groups appearing in the formulae in the specification, the term "lower" refers to a straight or branched carbon chain having 1 to 5 carbon atoms, preferably 1 to 3 carbon atoms. Accordingly, specific examples of lower alkyl groups include a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a pentyl (or amyl) group, an isopentyl group, a neopentyl group, a tert-pentyl group, etc.

  本发明涉及由式（I）表示的新型苯氧衍生物：##STR1## 其中：A是咪唑基团，吡啶基团，吡啶氧基团，氧代取代的香豆素氧基团，低碳基，氨基，该氨基可以被苯基或低碳基取代，或者是用环己氨基基团或咪唑基烷基基团取代的氨甲酰基基团；B是单键，可以被低碳基取代的噻唑基团，或由式表示的基团：--(CH.sub.2).sub.n --O--，--(CH.sub.2).sub.n CONH(CH.sub.2).sub.k --或--(CH.sub.2).sub.n --N(R.sup.4)--，其中k为0或1至5的整数，n为1至6的整数，R.sup.4为氢或低碳基；m为0或1至6的整数；R.sup.1为羟基，氨基或低烷氧基；R.sup.2和R.sup.3可以相同也可以不同，在此后均表示氢原子或低碳基；以及其盐。在规范中出现的基团的定义中，“低”一词是指具有1至5个碳原子的直链或支链碳链，最好是1至3个碳原子。因此，低碳基的具体例子包括甲基基团，乙基基团，丙基基团，异丙基基团，丁基基团，异丁基基团，仲丁基基团，叔丁基基团，戊基（或戊基）基团，异戊基基团，新戊基基团，叔戊基基团等。
• Phenoxy derivatives, their preparation, and pharmaceutical compositions containing them
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0130077A2

  公开（公告）日：1985-01-02

  A phenoxy compound represented by general formula (I), or a salt thereof wherein: A is an imidazolyl group, a pyridyl group, a pyridyloxy group, an oxo-substituted chromenyloxy group, a C1-C5 alkyl group, an amino group which may be substituted with a phenyl group or a C1-C5 alkyl group, or a carbamoyl group substituted with a cyclohexylamino group or an imidazolylalkyl group; B is a single bond, a thiazolyl group which may be substituted with a C1-C5 alkyl group, a group represented by formula: -(CH2)n-O-,-(CH2)nCONH(CH2)k-or-(CH2)n-N(R4)-wherein k is 0 or an integer of 1 to 5, n is an integer of 1 to 6 and R4 is a C1-C5 alkyl group; m is 0 or an integer of 1 to 6; R' is a hydroxyl group, an amino group ora C1-C5 alkoxy group; and R2 and R' are the same or different and selected from a hydrogen atom and C,-C5 alkyl groups. The compounds are effective for prophylaxis and treatment of arteriosclerosis, cerebal infraction, transient ischemic attack, angina pectoris, peripheral thrombus and obstruction.

  通式(I)代表的苯氧基化合物或其盐 其中 A 是咪唑基、吡啶基、吡啶氧基、氧代色原氧基、C1-C5 烷基、可被苯基或 C1-C5 烷基取代的氨基、或被环己基氨基或咪唑烷基取代的氨基甲酰基； B 是单键、可被 C1-C5 烷基取代的噻唑基、由式表示的基团：-(CH2)n-O-、-(CH2)nCONH(CH2)k-或-(CH2)n-N(R4)-其中 k 为 0 或 1 至 5 的整数，n 为 1 至 6 的整数，R4 为 C1-C5 烷基； m 为 0 或 1 至 6 的整数； R' 是羟基、氨基或 C1-C5 烷氧基；以及 R2 和 R'相同或不同，选自氢原子和 C,-C5烷基。 这些化合物可有效预防和治疗动脉硬化、脑梗塞、短暂性脑缺血发作、心绞痛、外周血栓和阻塞。
• US4794113A
  申请人：——

  公开号：US4794113A

  公开（公告）日：1988-12-27