bisacenaphthopyrazinoquinoxaline | 1190364-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: bisacenaphthopyrazinoquinoxaline
• 英文别名: 3,7,19,23-Tetrazanonacyclo[23.7.1.19,13.02,24.04,22.06,20.08,18.029,33.017,34]tetratriaconta-1(32),2,4,6(20),7,9,11,13(34),14,16,18,21,23,25,27,29(33),30-heptadecaene
• CAS: 1190364-17-0
• 化学式: C₃₀H₁₄N₄
• 分子量: 430.468
• InChiKey: PFQCFBDYRJMFIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bisacenaphthopyrazinoquinoxaline 在 硫酸 、 三氧化硫 作用下， 反应 4.0h， 以92%的产率得到3,7,19,23-Tetrazanonacyclo[23.7.1.19,13.02,24.04,22.06,20.08,18.029,33.017,34]tetratriaconta-1(32),2,4,6(20),7,9(34),10,12,14,16,18,21,23,25(33),26,28,30-heptadecaene-12,28-disulfonic acid
  参考文献：
  名称：

  [EN] LYOTROPIC LIQUID CRYSTAL SYSTEMS BASED ON BISACENAPHTHOPYRAZINOQUINOXALINE DERIVATIVES AND METHODS OF MAKING
  [FR] SYSTÈMES DE CRISTAUX LIQUIDES LYOTROPES BASÉS SUR DES DÉRIVÉS DE BISACÉNAPHTOPYRAZINOQUINOXALINE ET LEURS PROCÉDÉS DE FABRICATION

  摘要：

  本发明揭示了一种双萘并吡嗪喹喔啉衍生物家族，其化学式为(I)和(II)。这些化合物能够形成液晶系统，可以产生具有理想光学性能的光学各向同性或各向异性薄膜：(I)，(II)，其中Ri、R2、Rs、R4、R5和R&各自独立地选择自-H、-SO3M、-OH、-NH2、-Cl、-Br、-I、-NO2、-F、-CF3、-CN、-COOH、-CONH2、烷基、芳基、炔基、烯基、烷氧基、烷基氨基、苯氧基和苯基氨基基团; M是一个或多个计数离子; j是与化合物相关的计数离子数; n是在1到S范围内的整数。

  公开号：

  WO2009123968A1
• 作为产物：
  描述：

  苊醌 、 1,2,4,5-benzenetetraamine tetrahydrochloride 在 sodium acetate 作用下， 以 溶剂黄146 、 二甲基亚砜 为溶剂， 反应 48.0h， 以93%的产率得到bisacenaphthopyrazinoquinoxaline
  参考文献：
  名称：

  [EN] LYOTROPIC LIQUID CRYSTAL SYSTEMS BASED ON BISACENAPHTHOPYRAZINOQUINOXALINE DERIVATIVES AND METHODS OF MAKING
  [FR] SYSTÈMES DE CRISTAUX LIQUIDES LYOTROPES BASÉS SUR DES DÉRIVÉS DE BISACÉNAPHTOPYRAZINOQUINOXALINE ET LEURS PROCÉDÉS DE FABRICATION

  摘要：

  本发明揭示了一种双萘并吡嗪喹喔啉衍生物家族，其化学式为(I)和(II)。这些化合物能够形成液晶系统，可以产生具有理想光学性能的光学各向同性或各向异性薄膜：(I)，(II)，其中Ri、R2、Rs、R4、R5和R&各自独立地选择自-H、-SO3M、-OH、-NH2、-Cl、-Br、-I、-NO2、-F、-CF3、-CN、-COOH、-CONH2、烷基、芳基、炔基、烯基、烷氧基、烷基氨基、苯氧基和苯基氨基基团; M是一个或多个计数离子; j是与化合物相关的计数离子数; n是在1到S范围内的整数。

  公开号：

  WO2009123968A1

文献信息

• NON-FULLERENE ELECTRON ACCEPTORS FOR ORGANIC PHOTOVOLTAIC DEVICES
  申请人：UNIVERSITY OF WASINGTON

  公开号：US20170057962A1

  公开（公告）日：2017-03-02

  Non-fullerene electron acceptors for highly efficient organic photovoltaic devices are described. The non-fullerene electron acceptors have an extended, rigid, π-conjugated electron-deficient framework that can facilitate exciton and charge derealization. The non-fullerene electron acceptors can physically mix with a donor polymer and facilitate improved electron transport. The non-fullerene electron acceptors can be incorporated into organic electronic devices, such as photovoltaic cells.

  描述了用于高效有机光伏器件的非富勒烯电子受体。这些非富勒烯电子受体具有扩展的、刚性的、π共轭的电子亏损框架，可以促进激子和电荷的去局化。非富勒烯电子受体可以与给体聚合物物理混合，并促进改善的电子输运。非富勒烯电子受体可以被纳入有机电子器件，如光伏电池中。
• Methods for assaying palmitoyl protein thioesterase 1 and tripeptidyl peptidase activity in dried blood spots for detection of neuronal ceroid lipofuscinoses in newborns
  申请人：University of Washington

  公开号：US10788499B2

  公开（公告）日：2020-09-29

  The present disclosure provides assays for lysosomal enzymes, specifically palmitoyl protein thioesterase 1 (PPT1) and tripeptidyl peptidase 1 (TPP1), using, for example, tandem mass spectrometry. The assays involve the detection of enzymatic products obtained through the action of the lysosomal enzymes on new enzyme substrates, and can be used for quantitative enzyme activity measurements. The assays for the enzymes utilize a minimum steps for sample work up and can be run in a simplex format or in a duplex format for the detection of neuronal ceroid lipofuscinoses, or in a multiplex format with other mass spectrometry-based assays for screening of neuronal ceroid lipofuscinoses and other lysosomal storage disorders.

  本公开提供了溶酶体酶的检测方法，特别是棕榈酰蛋白硫酯酶 1 (PPT1) 和三肽基肽酶 1 (TPP1)，使用的方法包括串联质谱法等。这些检测方法包括检测溶酶体酶对新酶底物的作用所产生的酶产物，并可用于酶活性的定量测定。酶的检测只需最少的样品处理步骤，可采用单工或双工形式检测神经细胞类脂质病，或与其他基于质谱的检测方法一起采用多工形式筛查神经细胞类脂质病和其他溶酶体贮积症。
• LYOTROPIC LIQUID CRYSTAL SYSTEMS BASED ON BISACENAPHTHOPYRAZINOQUINOXALINE DERIVATIVES AND METHODS OF MAKING
  申请人：Zheng Shijun

  公开号：US20110026117A1

  公开（公告）日：2011-02-03

  A family of bisacenaphthopyrazinoquinoxaline derivatives of formula (I) and (II) is disclosed. These compounds are capable of forming liquid crystal systems that can produce optically isotropic or anisotropic films with desirable optical properties: (I), (II) wherein Ri, R2, Rs, R4, R5 and R& are each independently selected from —H, —SO 3 M, —OH, —NH 2 , —Cl, —Br, —I, —NO 2 , —F, —CF 3 , —CN, —COOH, —CONH 2 , alkyl, aryl, alkynyl, alkenyl, alkoxyl, alkylamino, phenoxyl, and phenylamino groups; M is one or more counter ions; j is the number of counter ions associated with the compound; and n is an integer in the range of 1 to S.
• METHODS FOR ASSAYING PALMITOYL PROTEIN THIOESTERASE 1 AND TRIPEPTIDYL PEPTIDASE ACTIVITY IN DRIED BLOOD SPOTS FOR DETECTION OF NEURONAL CEROID LIPOFUSCINOSES IN NEWBORNS
  申请人：University of Washington

  公开号：US20180209989A1

  公开（公告）日：2018-07-26

  The present disclosure provides assays for lysosomal enzymes, specifically palmitoyl protein thioesterase 1 (PPT1) and tripeptidyl peptidase 1 (TPP1), using, for example, tandem mass spectrometry. The assays involve the detection of enzymatic products obtained through the action of the lysosomal enzymes on new enzyme substrates, and can be used for quantitative enzyme activity measurements. The assays for the enzymes utilize a minimum steps for sample work up and can be run in a simplex format or in a duplex format for the detection of neuronal ceroid lipofuscinoses, or in a multiplex format with other mass spectrometry-based assays for screening of neuronal ceroid lipofuscinoses and other lysosomal storage disorders.
• US9809594B2
  申请人：——

  公开号：US9809594B2

  公开（公告）日：2017-11-07