3-hexylpyridazine | 90510-97-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-hexylpyridazine
• CAS: 90510-97-7
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: JBZIYBRHFPZFGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,1-Diethoxy-2-hydroxy-decan-4-one 在 硫酸肼 作用下， 以 甲醇 、 水 为溶剂， 反应 24.0h， 以85%的产率得到3-hexylpyridazine
  参考文献：
  名称：

  New routes to γ-ketoesters, β-hydroxy-δ-ketoesters, α,β-unsaturated γ-ketoaldehydes, and acetals. synthesis of cyclopentenones

  摘要：

  DOI：

  10.1016/s0040-4020(01)91249-9

文献信息

• Organic Compounds as Smo Inhibitors
  申请人：HE Feng

  公开号：US20100041663A1

  公开（公告）日：2010-02-18

  The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.

  本发明一般涉及与Hedgehog通路相关的病理诊断和治疗的新化合物，包括但不限于肿瘤形成、癌症、肿瘤和非恶性过度增殖性疾病。本发明包括新化合物、新组合物、它们的使用方法和制备方法，这些化合物通常在药理学上作为治疗剂是有用的，其作用机制涉及通过抑制Hedgehog和Smo信号通路的方法来抑制肿瘤发生、肿瘤生长和肿瘤存活。
• Anti-hypercholesterolemic biaryl azetidinone compounds
  申请人：Morriello Gregori J.

  公开号：US20080280836A1

  公开（公告）日：2008-11-13

  This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R 12 is an alkyl, alkeny or alkynyl group mono- or poly-substituted with —OH, —COOH or a combination of —OH and —COOH, and R 9 contains an alkyl, alkeny or alkynyl group substituted with a heterocyclic ring, amino or sulfonyl. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

  这项发明提供了化学式I的胆固醇吸收抑制剂及其药用盐，其中R12是一个烷基、烯烃或炔烃基，单取代或多取代于—OH、—COOH或—OH和—COOH的组合，而R9含有一个被杂环环、氨基或磺酰基取代的烷基、烯烃或炔烃基。这些化合物对降低血浆胆固醇水平，特别是LDL胆固醇，以及治疗动脉粥样硬化和预防动脉粥样硬化疾病事件具有用处。
• [EN] CHIRAL COMPOUNDS II<br/>[FR] COMPOSES CHIRAUX DE TYPE II
  申请人：MERCK PATENT GMBH

  公开号：WO2002006195A1

  公开（公告）日：2002-01-24

  The invention relates to chiral compounds of formula (I) R?1-X1-(A1-Z1)¿m-G-(Z2-A2)n-X2-R2, wherein R?1, R2, X1, X2, A1, A2, Z1, Z2¿, G, m and n have the meaning given in claim 1, to liquid crystalline mixtures comprising at least one chiral compound of formula (I), to chiral linear or crosslinked liquid crystalline polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formual (I), to the use of chiral compounds of formula (I) and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula (I).

  该发明涉及具有式(I)的手性化合物，其中R?1、R2、X1、X2、A1、A2、Z1、Z2、G、m和n的含义如权利要求1中所述，涉及至少包含一种式(I)手性化合物的液晶混合物，可通过聚合包含至少一种式(I)手性化合物的可聚合混合物获得手性线性或交联液晶聚合物，以及手性化合物的使用(I)和由此获得的混合物和聚合物在液晶显示器、主动和被动光学元件、粘合剂、具有各向异性机械性能的合成树脂、化妆品和药用组合物、诊断、液晶颜料、用于装饰和安全应用、非线性光学、光学信息存储或作为手性掺杂剂，并涉及包含至少一种式(I)手性化合物的混合物的液晶显示器。
• [EN] CYANOPYRIDONE DERIVATIVES AS LIQUID CRYSTALS<br/>[FR] DERIVES DE CYANOPYRIDONE UTILISES SOUS FORME DE CRISTAUX LIQUIDES
  申请人：MERCK PATENT GMBH

  公开号：WO2004074253A1

  公开（公告）日：2004-09-02

  The invention relates to cyanopyridone derivatives, to their use in liquid crystal media, liquid crystal devices, anisotropic polymers, optical, electrooptical, decorative, security, cosmetic, diagnostic, pharmaceutic, electric, electronic, charge transport, semiconductor, optical recording, electroluminescent, photoconductor and electrophotographic applications, and to liquid crystal media, polymers and displays comprising them.

  该发明涉及氰吡啶酮衍生物，其在液晶介质、液晶器件、各种聚合物、光学、电光学、装饰、安全、化妆品、诊断、药物、电气、电子、电荷传输、半导体、光记录、电致发光、光电导体和电子摄影应用中的使用，以及包含它们的液晶介质、聚合物和显示器。
• [EN] CHIRAL COMPOUNDS I<br/>[FR] COMPOSES CHIRAUX I
  申请人：MERCK PATENT GMBH

  公开号：WO2002006196A1

  公开（公告）日：2002-01-24

  The invention relates to chiral compounds of formula (I) wherein R?1, R2, A1, A2, X1, X2, Z3¿ and m have the meaning given in claim 1, to liquid crystalline mixtures comprising at least one chiral compound of formula (I), to chiral linear or crosslinked liquid crystalline polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formula (I), to the use of chiral compounds of formula (I) and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula (I).

  本发明涉及式(I)的手性化合物，其中R?1，R2，A1，A2，X1，X2，Z3¿和m具有权利要求书中给出的含义，涉及至少包含式(I)的手性化合物的液晶混合物，可通过聚合聚合物化可混合物获得手性线性或交联液晶聚合物，涉及在液晶显示器，活性和被动光学元件，粘合剂，具有各向异性机械性能的合成树脂，化妆品和制药组合物，诊断，液晶颜料，用于装饰和安全应用，非线性光学，光学信息存储或作为手性掺杂剂中使用式(I)的手性化合物，混合物和聚合物，以及液晶显示器，其中包括至少一种包含式(I)的手性化合物的混合物。