N-n-amylhydroxylamine | 63094-58-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-n-amylhydroxylamine
• 英文别名: N-pentyl-hydroxylamine；amyl alcoholamine；N-pentylhydroxylamine
• CAS: 63094-58-6
• 化学式: C₅H₁₃NO
• 分子量: 103.164
• InChiKey: XEZLAJRZQNKEOJ-UHFFFAOYSA-N

物化性质

• 沸点：
  161.2±23.0 °C(Predicted)
• 密度：
  0.878±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  7
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-n-amylhydroxylamine 在 sodium hydride 、 碳酸氢钠 、 N,N-二异丙基乙胺 、 溶剂红 43 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 37.0h， 生成 ethyl 7-benzamido-4-methyl-2-methyleneheptanoate
  参考文献：
  名称：

  有机光氧化还原催化未活化的sp3 C-H键的酰胺基自由基定向远程烯丙基化

  摘要：

  报道了未激活的sp 3 C-H键的可见光介导的烯丙基化的发展。远程烯丙基化是由酰胺基进行的，该酰胺基是由预官能化酰胺前体的光催化裂解生成的。芳香族和脂肪族酰胺衍生物均可成功地以高收率交付偏远的CH烯丙基化产物。多种缺电子的烯丙基砜系统可用作δ-碳自由基受体。

  DOI：

  10.1002/anie.201811004
• 作为产物：
  描述：

  1-硝基戊烷 在 高氯酸 、 辛醇 、 sodium perchlorate 作用下， 生成 N-n-amylhydroxylamine
  参考文献：
  名称：

  Bogucka; Gromulska; Stroka, Polish Journal of Chemistry, 2001, vol. 75, # 1, p. 93 - 104

  摘要：

  DOI：

文献信息

• 3-Oxo-5,6-dihydro-1,2,4-oxadiazines useful as antiandrogenic agents
  申请人：Roussel Uclaf

  公开号：US04108993A1

  公开（公告）日：1978-08-22

  Antiandrogenic compositions comprising an effective amount of at least one compound of the formula ##STR1## wherein X and Y are individually selected from the group consisting of hydrogen, halogen, --CF.sub.3, --NO.sub.3 and alkylthio of 1 to 4 carbon atoms and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, benzyl and hydroxymethyl and an inert pharmaceutical carrier and a method of inducing antiandrogenic activity in warm-blooded animals as well as novel oxadiazines of formula I with the proviso that when R is other than benzyl or hydroxymethyl at least one of X and Y is alkylthio of 1 to 4 carbon atoms.

  抗雄激素组合物包括至少一种符合以下式的化合物的有效量##STR1##其中X和Y分别选自氢、卤素、--CF.sub.3、--NO.sub.3和1至4个碳原子的烷基硫，并且R选自氢、1至6个碳原子的烷基、苯基、苄基和羟甲基，以及惰性药用载体和在温血动物中诱导抗雄激素活性的方法，以及具有以下式I的新颖噁二唑，但是当R不是苄基或羟甲基时，X和Y中至少有一个是1至4个碳原子的烷基硫。
• Perronnet, Jacques; Girault, Pierre; Demoute, Jean-Pierre, Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 727 - 731
  作者：Perronnet, Jacques、Girault, Pierre、Demoute, Jean-Pierre

  DOI：——

  日期：——
• Role of Hydrophobic Interactions in Binding <i>S</i>-(<i>N</i>-Aryl/Alkyl-<i>N</i>-hydroxy- carbamoyl)glutathiones to the Active Site of the Antitumor Target Enzyme Glyoxalase I
  作者：Avinash Kalsi、Malcolm J. Kavarana、Tianfen Lu、Dale L. Whalen、Diana S. Hamilton、Donald J. Creighton

  DOI：10.1021/jm000160l

  日期：2000.10.1

  Hydrophobic interactions play an important role in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active sites of human, yeast, and Pseudomonas putida glyoxalase I, as the log K-i values for these mechanism-based competitive inhibitors decrease linearly with increasing values of the hydrophobicity constants (pi) of the N-aryl/alkyl substituents. Hydrophobic interactions also help to optimize polar interactions between the enzyme and the glutathione derivatives, given that the K-i value for S-(N-hydroxycarbamoyl)glutathione (pi = 0) with the human enzyme is 35-fold larger than the interpolated value for this compound obtained from the log K-i versus pi plot. Computational studies, in combination with published X-ray crystallographic measurements, indicate that human glyoxalase I binds the syn-conformer of S-(N-aryl-N-hydroxycarbamoyl)glutathione in which the N-aryl substituents are in their lowest-energy conformations. These studies provide both an experimental and a conceptual framework for developing better inhibitors of this antitumor target enzyme.
• N-(1-Cyanocyclohexyl)-C-phenylnitrones and Glyoxaldinitrones
  作者：Rainer Camehn、Klaus Rehse

  DOI：10.1002/(sici)1521-4184(20005)333:5<130::aid-ardp130>3.0.co;2-d

  日期：2000.5

  Six N-(1-cyanocyclohexyl)-C-phenylnitrones 4a-f (4b-f for the first time) and 22 glyoxaldinitrones 7a-v were prepared and tested for antithrombotic (p.o. administration to rats, 60 mg/kg) effects. Both classes of compounds exhibit considerable antithrombotic activities. Maximum inhibition of thrombus formation in arterioles (21%) was observed in N,N'-bis-2-phenylethylglyoxaldinitrone (7o) and N,N'-bis-4-nitrobenzylglyoxaldinitrone (7u). The compounds form only small amounts of nitric oxide in vitro by the addition of a Fe3+-porphyrine complex and an oxygen donor.
• DE951933
  申请人：——

  公开号：——

  公开（公告）日：——