4-fluoro-toluene-2-sulfonic acid | 364-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-fluoro-toluene-2-sulfonic acid
• 英文别名: 4-Fluor-toluol-2-sulfonsaeure；5-fluoro-2-methylbenzenesulphonate；5-Fluoro-2-methylbenzenesulfonic acid
• CAS: 364-14-7
• 化学式: C₇H₇FO₃S
• 分子量: 190.195
• InChiKey: JTESIRYXMHLYMT-UHFFFAOYSA-N

物化性质

• 密度：
  1.433±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氨基甲苯-2-磺酸 生成 4-fluoro-toluene-2-sulfonic acid
  参考文献：
  名称：

  de Roode, American Chemical Journal, 1891, vol. 13, p. 219

  摘要：

  DOI：

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1880993A1

  公开（公告）日：2008-01-23

  The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I): wherein W represents a nitrogen atom or -CH-; X represents -C(=O)- or -CHR4- (wherein R4 represents a hydrogen atom, or the like); R1 represents a group represented by the following formula: [wherein Q1 represents a nitrogen atom or -CR8- (wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like), Q2 represents -NR15- (wherein R15 represents a hydrogen atom, or the like) and R5 and R6 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like]; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like } or a pharmaceutically acceptable salt thereof, and the like.

  本发明提供了一种由式（I）表示的含氮杂环化合物： 其中 W 代表氮原子或-CH-； X代表-C(＝O)-或-CHR4-（其中R4代表氢原子或类似物）； R1 代表下式所代表的基团： [其中 Q1 代表氮原子或-CR8-（其中 R8 代表氢原子、取代或未取代的低级烷基或类似物），Q2 代表-NR15-（其中 R15 代表氢原子或类似物），R5 和 R6 可以相同或不同，各自代表氢原子、取代或未取代的低级烷基或类似物]；以及 R2 和 R3 可以相同或不同，各自代表氢原子、卤素、取代或未取代的低级烷基或类似物 } 或其药学上可接受的盐等。
• Preparation of a pathogen inactivated solution of red blood cells having reduced immunogenicity
  申请人：——

  公开号：US20020042043A1

  公开（公告）日：2002-04-11

  Compounds and methods are provided for the preparation of a red blood cell composition which has significantly reduced antigenicity and in which any possible pathogen contaminants have been substantially inactivated. The red blood cell compositions are of particular use for introduction into an individual in cases where the potential for an immune reaction is high, for example in alloimmunized blood recipients or in trauma situations where the possibility of transfusion of a mismatched unit of blood is higher. The red blood cell compositions of this invention provide a much lower risk of transfusion associated disease transmission as well as a much lower risk of a transfusion associated immune reaction.

  本发明提供了制备红细胞组合物的化合物和方法，这种组合物的抗原性大大降低，其中任何可能的病原体污染物都已基本灭活。这种红细胞组合物特别适用于在免疫反应可能性较高的情况下输入个人体内，例如异体免疫的受血者或在创伤情况下输注不匹配单位血液的可能性较高。本发明的红细胞组合物大大降低了输血相关疾病传播的风险，也大大降低了输血相关免疫反应的风险。
• Preparation of red blood cells having reduced immunogenicity
  申请人：Cerus Corporation

  公开号：US20030207247A1

  公开（公告）日：2003-11-06

  Methods are provided for the preparation of an RBC composition which has significantly reduced antigenicity. The methods of preparation of the red cell compositions involve the optimization of reaction conditions, in particular buffering conditions, for attaching antigen masking compounds to the red cells without significantly affecting the function of the red cells. The RBC compositions are of particular use for introduction into an individual in cases where the potential for an immune reaction is high, for example in alloimmunized blood recipients or in trauma situations where the possibility of transfusion of a mismatched unit of blood is higher. The RBC compositions of this invention provide a much lower risk of a transfusion associated immune reaction.

  本发明提供了制备抗原性显著降低的红细胞组合物的方法。制备红细胞组合物的方法包括优化反应条件，特别是缓冲条件，以便在不明显影响红细胞功能的情况下将抗原掩蔽化合物附着在红细胞上。这种红细胞组合物尤其适用于在免疫反应可能性较高的情况下，例如在异体免疫的受血者或创伤情况下，输注不匹配的血液单位的可能性较高的情况下，将其输入个人体内。本发明的红细胞组合物可大大降低输血相关免疫反应的风险。
• PEGYLATION PROCESS
  申请人：PolyMASC Pharmaceuticals plc

  公开号：EP0921817B1

  公开（公告）日：2001-03-28
• Cerfontain, Hans; Koeberg-Telder, Ankie; Laali, Khosrow, Recueil des Travaux Chimiques des Pays-Bas, 1982, vol. 101, # 11, p. 390 - 392
  作者：Cerfontain, Hans、Koeberg-Telder, Ankie、Laali, Khosrow、Lambrechts, Hans J. A.、Wit, Peter de

  DOI：——

  日期：——