N-(3,3′-dimethylbiphenyl-2-yl)formamide | 1608474-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,3′-dimethylbiphenyl-2-yl)formamide
• 英文别名: N-[2-methyl-6-(3-methylphenyl)phenyl]formamide
• CAS: 1608474-11-8
• 化学式: C₁₅H₁₅NO
• 分子量: 225.29
• InChiKey: OXGHBELUBZEGBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  邻甲苯胺 在 silver tetrafluoroborate 、 palladium diacetate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 N-(3,3′-dimethylbiphenyl-2-yl)formamide
  参考文献：
  名称：

  Palladium-Catalyzed C(sp²)–H Arylation Using Formamide as a Transformable Directing Group

  摘要：

  A new process for the ortho arylation of formanilides through palladium-catalyzed C-H activation is described. Formamide is reported as a transformable directing group in the transition-metal-catalyzed C-H functionalization reaction. The resulting biarylformanilide products can be readily transformed to the corresponding biarylisocyanides or N-heterocycles.

  DOI：

  10.1021/jo5007043

文献信息

• Palladium-Catalyzed C(sp²)–H Arylation Using Formamide as a Transformable Directing Group
  作者：Congqing Wan、Jiaji Zhao、Mingfang Xu、Jinbo Huang

  DOI：10.1021/jo5007043

  日期：2014.5.16

  A new process for the ortho arylation of formanilides through palladium-catalyzed C-H activation is described. Formamide is reported as a transformable directing group in the transition-metal-catalyzed C-H functionalization reaction. The resulting biarylformanilide products can be readily transformed to the corresponding biarylisocyanides or N-heterocycles.