| 1221177-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• CAS: 1221177-03-2
• 化学式: C₂₀H₂₀N₄O₂
• 分子量: 348.404
• InChiKey: PMWOWCIKJQSQKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基苯甲酰胺 、 1,4-环己二酮 在 碘 作用下， 反应 4.0h， 以96%的产率得到
  参考文献：
  名称：

  离子液体中碘催化组合合成2,2-二取代喹唑啉-4（1 H）-one衍生物的简便方法

  摘要：

  为喹唑啉4-（1的组合合成的温和和容易的方法ħ） -酮衍生物，含有简单2,2-二取代的喹唑啉4-（1 ħ） -酮，螺喹唑啉4-（1- ħ） -的，螺-杂环喹唑啉4-（1 ħ） -酮，和dispirocyclic喹唑啉4-（1 ħ） -酮，描述，其结果以高收率通过使用离子液体作为绿色介质。该方法涉及2-氨基苯甲酰胺与碘催化的各种酮的反应，并提供了用于生物医学筛选的新的喹唑啉-4-（1 H）-一文库。

  DOI：

  10.1021/cc900174p

文献信息

• Probing the catalytic activity of highly efficient sulfonic acid fabricated cobalt ferrite magnetic nanoparticles for the clean and scalable synthesis of dihydro, spiro and bis quinazolinones
  作者：Priyanka Yadav、Satish K. Awasthi

  DOI：10.1039/d1nj01149a

  日期：——

  An exceptionally productive, rapid, simple, and eco-friendly approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one has been developed utilizing acidic magnetically retrievable cobalt ferrite nanoparticles (CFNP@SO₃H).

  一个异常高效、快速、简单且环保的方法已经开发出来，用于合成2,3-二氢喹唑啉-4(1H)-酮，利用了酸性可磁回收的钴铁氧化物纳米颗粒（CFNP@SO3H）。
• Facile Method for the Combinatorial Synthesis of 2,2-Disubstituted Quinazolin-4(1<i>H</i>)-one Derivatives Catalyzed by Iodine in Ionic Liquids
  作者：Xiang-Shan Wang、Ke Yang、Jie Zhou、Shu-Jiang Tu

  DOI：10.1021/cc900174p

  日期：2010.7.12

  A mild and facile method for the combinatorial synthesis of quinazolin-4-(1H)-one derivatives, containing simple 2,2-disubstituted quinazolin-4-(1H)-ones, spirocyclic quinazolin-4-(1H)-ones, spiro-heterocyclic quinazolin-4-(1H)-ones, and dispirocyclic quinazolin-4-(1H)-ones, is described, which results in high yields by using ionic liquids as green media. The method involves the reaction of 2-aminobenzamides

  为喹唑啉4-（1的组合合成的温和和容易的方法ħ） -酮衍生物，含有简单2,2-二取代的喹唑啉4-（1 ħ） -酮，螺喹唑啉4-（1- ħ） -的，螺-杂环喹唑啉4-（1 ħ） -酮，和dispirocyclic喹唑啉4-（1 ħ） -酮，描述，其结果以高收率通过使用离子液体作为绿色介质。该方法涉及2-氨基苯甲酰胺与碘催化的各种酮的反应，并提供了用于生物医学筛选的新的喹唑啉-4-（1 H）-一文库。
• A Brønsted Acid Ionic Liquid Immobilized on Fe3O4@SiO2 Nanoparticles as an Efficient and Reusable Solid Acid Catalyst for the Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones
  作者：M. Fallah-Mehrjardi、S. Kalantari

  DOI：10.1134/s1070428020020207

  日期：2020.2

  In the present study, an efficient and magnetically recoverable Bronsted acid ionic liquid, 1-methyl-3-[3-(triethoxysilyl)propyl]-1H-imidazol-3-ium hydrogen sulfate, immobilized on the surface of Fe3O4@SiO2 magnetic nanoparticles (Fe3O4@SiO2-ImHSO(4)) has been used for a high-yield synthesis of 2,3-dihydroquinazolin-4(1H)-ones through the condensation of anthranilamide with aldehydes and ketones in EtOH at room temperature or under reflux. The significant features of the present protocol are short reaction times, high yields of products, ecofriendly reaction conditions, simple work-up, and reusability of the catalyst. The catalyst can be simply magnetically recovered and reused at least five times without considerable loss of its catalytic activity.
• Glycerol based ionic liquid with a boron core: A new highly efficient and reusable promoting medium for the synthesis of quinazolinones
  作者：Hamid Reza Safaei、Mohsen Shekouhy、Vahid Shafiee、Mansooreh Davoodi

  DOI：10.1016/j.molliq.2013.01.013

  日期：2013.4

  A highly efficient and environmental benign procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones via the condensation of carbonyl compounds with 2-aminobenzamide using a glycerol based ionic liquid with a boron core as a new and reusable promoting medium is described. A broad range of substrates including aldehydes and ketone were condensed with 2-aminobenzamide. All reactions are completed in short times and the products are obtained in good to excellent yields. The reaction medium could be recycled and reused several times without any loss of efficiency. Moreover, presented procedure has been applied successfully for the synthesis of some novel bis(pyrazolinone) derivatives. (C) 2013 Elsevier B.V. All rights reserved.
• Sulfonated Ethylenediamine Functionalized Magnetic Nanoparticles as a Highly Efficient Heterogeneous Nanocatalyst for the Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones
  作者：Mehdi Fallah-Mehrjardi、Fatemeh Hakimi、Iman Salimi

  DOI：10.2174/1570178619666220127123444

  日期：2022.10

  In the present study, a new magnetically recyclable nanocatalyst, Fe₃O₄@SiO₂@(CH₂)₃-en- SO₃H/H₂SO₄, was prepared through the immobilization of sulfonated ethylenediamine on the silicacoated magnetite nanoparticles. The catalyst was fully characterized by several physicochemical techniques, including FT-IR, FESEM, TEM, EDS, VSM, XRD and TGA. The resultant nanocatalyst was then utilized in the green synthesis of 2,3-dihydroquinazolin-4(1H)-ones via the cyclocondensation reaction of various aldehydes and ketones with anthranilamide in refluxed EtOH. Short reaction times, high product yields, environmentally friendly reaction conditions, simple operation and reusability of the catalyst are important features of the present procedure. The catalyst can magnetically be recycled and reused several times without notable loss in the activity.

  摘要 本研究通过将磺化乙二胺固定在硅胶涂层上，制备了一种新型磁性可回收纳米催化剂--Fe3O4@SiO2@(CH2)3-en- SO3H/H2SO4 。 SO3H/H2SO4。 磁铁矿纳米颗粒上。该催化剂采用多种物理化学技术进行了全面表征、 包括 FT-IR、FESEM、TEM、EDS、VSM、XRD 和 TGA。催化剂 然后利用该纳米催化剂，通过各种醛和化合物的环缩合反应，绿色合成 2,3-二氢喹唑啉-4(1H)-酮。 2,3- 二氢喹唑啉-4(1H)-酮的绿色合成。反应时间短 反应时间短、产品收率高、反应条件环保、操作简单以及催化剂可重复使用 催化剂可重复使用是本工艺的重要特点。催化剂可以通过磁力回收 催化剂可以磁力回收并重复使用多次，而活性不会明显降低。