申请人:Karos Pharmaceuticals, Inc.
公开号:US20150080393A1
公开(公告)日:2015-03-19
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.
本发明涉及螺环化合物,它们是色氨酸羟化酶(TPH)的抑制剂,特别是isoform 1(TPH1),可用于治疗与外周血清素相关的疾病或疾病,例如胃肠道、心血管、肺部、炎症、代谢和低骨量疾病,以及血清素综合症和癌症。