1,1,1-trifluoro-N-((trifluoromethyl)sulfonyl)-N-(4-vinylphenyl)methanesulfonamide | 838884-10-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,1-trifluoro-N-((trifluoromethyl)sulfonyl)-N-(4-vinylphenyl)methanesulfonamide
• 英文别名: N,N-Bis(trifluoromethanesulfonyl)-4-vinylaniline；N-(4-ethenylphenyl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
• CAS: 838884-10-9
• 化学式: C₁₀H₇F₆NO₄S₂
• 分子量: 383.292
• InChiKey: JCQVNHFOPVJRBW-UHFFFAOYSA-N

物化性质

• 沸点：
  361.3±52.0 °C(Predicted)
• 密度：
  1.679±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  1,1,1-trifluoro-N-((trifluoromethyl)sulfonyl)-N-(4-vinylphenyl)methanesulfonamide 在 pyridine hydrofluoride 、 4-碘甲苯 、 Selectfluor 作用下， 以 氯仿 为溶剂， 反应 29.03h， 以57%的产率得到N-(4-(2,2-difluoroethyl)phenyl)-1,1,1-trifluoro-N-((trifluoromethyl)sulfonyl)-methanesulfonamide
  参考文献：
  名称：

  Catalytic Geminal Difluorination of Styrenes for the Construction of Fluorine-rich Bioisosteres

  摘要：

  A geminal difluorination of alkenes based on I(I)/I(III) catalysis is disclosed, which is compatible with a range of electronically and substitutionally diverse styrenes (27 examples, up to 89% yield). Employing inexpensive p-Toll as the organocatalyst, turnover is enabled by Selectfluor-mediated oxidation to generate the ArIF2 species in situ. Extension to include alpha-substituted styrenes bearing fluorine-containing groups is disclosed and provides an expansive platform for the generation of fluorine-rich architectures.

  DOI：

  10.1021/acs.orglett.8b03794
• 作为产物：
  描述：

  三氟甲磺酸酐 、 4-乙烯苯胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以80%的产率得到1,1,1-trifluoro-N-((trifluoromethyl)sulfonyl)-N-(4-vinylphenyl)methanesulfonamide
  参考文献：
  名称：

  烯烃的对映选择性催化邻二氟化

  摘要：

  I / I III催化使用新型C 2对称间苯二酚衍生物进行烯烃的对映选择性催化邻位二氟化反应。通过Selectfluor氧化和添加廉价的HF-胺络合物，可以原位生成ArI III F 2物种进行催化剂转换。此过程中使用的HF：胺比率为布朗选择性酸度的区域选择性正交性提供了一个解决方案。公开了从1,1-二氟化途径（基因）向所需的1,2-二氟化途径（邻位）的选择性逆转（两个方向均> 20：1）。用电子不足的苯乙烯进行验证有助于产生古老的CF 3的手性生物等排体药物发现中普遍使用的单元（20个示例，最高94:06 er）。还使用p- TolI（高达> 95％的收率）显示了反应的非手性变体。

  DOI：

  10.1002/anie.201810328

文献信息

• Catalytic cyclopropanation reactions with α-silyl-, germanyl- and stannyl carbenes generated from cyclopropenes
  作者：Darío Coto、Iratxe Barbolla、Rubén Vicente

  DOI：10.1039/d2cc03338k

  日期：——

  as precursors of α-silyl vinyl carbenes and trapped with alkenes. Cyclopropylsilanes were obtained in good yields with ample scope and complete regio- and diastereoselectivity. Stereoretentive protodesilylations enabled access to cis-1,2-disubstituted cyclopropanes. Cyclopropylstannanes and -germanes can also be prepared from the corresponding cyclopropenes.

  甲硅烷基环丙烯用作 α-甲硅烷基乙烯基卡宾的前体并被烯烃捕获。环丙基硅烷以良好的收率获得，具有广泛的范围和完全的区域和非对映选择性。立体保留的 protodesylations 使获得顺式-1,2-二取代环丙烷成为可能。环丙基锡烷和锗烷也可以由相应的环丙烯制备。
• WO2007/126262
  申请人：——

  公开号：——

  公开（公告）日：——
• A polystyrene-supported triflating reagent for the synthesis of aryl triflates
  作者：Cecilia Wan Ying Chung、Patrick H. Toy

  DOI：10.1016/j.tet.2004.10.108

  日期：2005.1

  An insoluble polystyrene-supported triflating reagent has been prepared by suspension co-polymerization of N-(4-vinylphenyl)trifluoromethanesulphonimide, styrene and the JandaJel((R)) cross-linker. This reagent, in the presence of triethylamine, allows for the efficient synthesis of aryl triflates from a wide range of phenols in a process that permits the desired product to be isolated from the reaction mixture in essentially pure form via several filtration and concentration operations. Adding to the utility of this reagent is its ability to be easily recovered, regenerated and reused. Both soluble and insoluble bifunctional polymers containing trialkylamine moieties in addition to triflimide groups were also prepared and examined as triflating reagents. Unfortunately these reagents afforded only modest yields of the desired products in representative reactions. (C) 2004 Elsevier Ltd. All rights reserved.
• ORGANIC PIEZOELECTRIC MATERIAL, ULTRASONIC OSCILLATOR USING THE SAME, METHOD FOR PRODUCING THE ULTRASONIC OSCILLATOR, ULTRASONIC PROBE AND ULTRASONIC MEDICAL DIAGNOSTIC IMAGING DEVICE
  申请人：Morita Kiyokazu

  公开号：US20110004102A1

  公开（公告）日：2011-01-06

  Disclosed is an organic piezoelectric material which has particularly excellent heat resistance, while exhibiting excellent transparency, surface gloss, adhesion and piezoelectric characteristics. Also disclosed are an ultrasonic oscillator used in an ultrasonic medical diagnostic imaging device, which is capable of highly sensitively receiving a high frequency wave and suitable for harmonic imaging technique, a method for producing the ultrasonic oscillator, an ultrasonic probe, and an ultrasonic medical diagnostic imaging device. The organic piezoelectric material is characterized in that the piezoelectric material is formed by laminating two or more films at the same time by a coating process.
• ORGANIC PIEZOELECTRIC MATERIAL, ULTRASONIC OSCILLATOR USING THE MATERIAL, METHOD FOR MANUFACTURING THE ULTRASONIC OSCILLATOR, ULTRASONIC PROBE, AND ULTRASONIC MEDICAL DIAGNOSTIC IMAGING DEVICE
  申请人：Morita Kiyokazu

  公开号：US20110021916A1

  公开（公告）日：2011-01-27

  Provided is an organic piezoelectric material which has excellent piezoelectric property, heat resistance property in particular. An ultrasonic oscillator, which is to be used for an ultrasonic medical diagnostic imaging device which can receive high frequencies at high sensitivity and is suitable for harmonic imaging techniques, a method for manufacturing such oscillator, and an ultrasonic probe are also provided. The ultrasonic medical diagnostic imaging device is provided by sing such oscillator, method and probe. The organic piezoelectric material is characterized by containing empty particles having an average particle diameter of 10 μm or less.