4-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-2-(2,3,5-trichlorophenyl)-1,3-thiazole | 1018688-16-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-2-(2,3,5-trichlorophenyl)-1,3-thiazole
• CAS: 1018688-16-8
• 化学式: C₁₆H₁₂Cl₃N₃S₂
• 分子量: 416.782
• InChiKey: HXOPBPNJZAUOJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  92.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-chloromethyl-2-(2,3,5-trichlorophenyl)-1,3-thiazole 、 4,6-二甲基-2-巯基嘧啶 在 sodium hydroxide 作用下， 以 various solvent(s) 为溶剂， 以83%的产率得到4-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-2-(2,3,5-trichlorophenyl)-1,3-thiazole
  参考文献：
  名称：

  Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents

  摘要：

  A series of novel 4-aryl/chloroalkyl-2-(2,3,5-trichlorophenyl)-1,3-thiazoles (5a-g and 7a-e) were synthesized by condensing 2,3,5-trichlorobenzenecarbothioamide with phenacyl bromide/dichloroacetone. 2,3,5-Trichlorobenzaldehyde thiosemicarbazone on treatment with phenacyl bromide afforded 4-aryl-2-(2,3,5-trichlorophenylidenehydrazino)-1,3-thiazoles (10a-g) in good yield. The newly synthesized compounds are characterized by IR, H-1 NMR and mass spectral studies. These compounds were also screened for their antibacterial and antifungal activities. Preliminary results reveal that some of the synthesized compounds are showing promising antimicrobial activity. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.03.014

文献信息

• Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents
  作者：Prakash Karegoudar、Mari Sithambaram Karthikeyan、Dasappa Jagadeesh Prasad、Manjathuru Mahalinga、Bantwal Shivarama Holla、Nalilu Sucheta Kumari

  DOI：10.1016/j.ejmech.2007.03.014

  日期：2008.2

  A series of novel 4-aryl/chloroalkyl-2-(2,3,5-trichlorophenyl)-1,3-thiazoles (5a-g and 7a-e) were synthesized by condensing 2,3,5-trichlorobenzenecarbothioamide with phenacyl bromide/dichloroacetone. 2,3,5-Trichlorobenzaldehyde thiosemicarbazone on treatment with phenacyl bromide afforded 4-aryl-2-(2,3,5-trichlorophenylidenehydrazino)-1,3-thiazoles (10a-g) in good yield. The newly synthesized compounds are characterized by IR, H-1 NMR and mass spectral studies. These compounds were also screened for their antibacterial and antifungal activities. Preliminary results reveal that some of the synthesized compounds are showing promising antimicrobial activity. (c) 2007 Elsevier Masson SAS. All rights reserved.