4-Chloro-2-(3-methoxyphenyl)phenol | 565203-87-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chloro-2-(3-methoxyphenyl)phenol
• CAS: 565203-87-4
• 化学式: C₁₃H₁₁ClO₂
• 分子量: 234.682
• InChiKey: RXLVQKOJNYGRPL-UHFFFAOYSA-N

物化性质

• 沸点：
  357.0±27.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Chloro-2-(3-methoxyphenyl)phenol 在 bis-triphenylphosphine-palladium(II) chloride 、 二乙基异丙基胺 作用下， 生成 2-[4-chloro-2-(3-methoxyphenyl)phenyl]ethynyl-trimethylsilane
  参考文献：
  名称：

  Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor

  摘要：

  Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00122-7
• 作为产物：
  描述：

  4-氯-2-碘苯甲醚, 在 四(三苯基膦)钯 、 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 4-Chloro-2-(3-methoxyphenyl)phenol
  参考文献：
  名称：

  Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor

  摘要：

  Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00122-7

文献信息

• One pot synthesis of bioactive benzopyranones through palladium-catalyzed C–H activation and CO insertion into 2-arylphenols
  作者：Tai-Hua Lee、Jayachandran Jayakumar、Chien-Hong Cheng、Shih-Ching Chuang

  DOI：10.1039/c3cc47197g

  日期：——

  Palladium-catalyzed oxidative carbonylation of 2-arylphenols through C-H bond activation and C-C and C-O bond formation under acid-base free and mild conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important benzopyranone derivatives in up to 87% isolated yield.

  已经开发了在无酸碱和温和条件下通过CH键活化以及CC和CO键形成的钯催化的2-芳基苯酚的氧化羰基化反应。该反应可耐受多种底物，并以高达87％的分离产率提供生物学上重要的苯并吡喃酮衍生物。
• Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor
  作者：Nan-Horng Lin、Le Wang、Jerry Cohen、Wen-Zhen Gu、David Frost、Haiying Zhang、Saul Rosenberg、Hing Sham

  DOI：10.1016/s0960-894x(03)00122-7

  日期：2003.4

  Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented. (C) 2003 Elsevier Science Ltd. All rights reserved.