2-叔丁基-1,3-二氧代-2,3-二氢-1H-异吲哚-5-羧酸 | 57151-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: 2-叔丁基-1,3-二氧代-2,3-二氢-1H-异吲哚-5-羧酸
• 英文名称: 2-Tert-butyl-1,3-dioxoisoindoline-5-carboxylic acid
• 英文别名: 2-tert-butyl-1,3-dioxoisoindole-5-carboxylic acid
• CAS: 57151-82-3
• 化学式: C₁₃H₁₃NO₄
• mdl: MFCD01005664
• 分子量: 247.25
• InChiKey: XBMWXWYNYYVTMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2925190090

文献信息

• Vanilloid receptor ligands and their use in treatments
  申请人：Hulme Christopher

  公开号：US20050165046A1

  公开（公告）日：2005-07-28

  bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  双环酰胺及其衍生物以及含有它们的组合物，用于治疗急性、炎症性和神经痛、牙痛、普通头痛、偏头痛、集群头痛、混合血管性和非血管性综合征、紧张性头痛、一般炎症、关节炎、风湿病、骨关节炎、炎症性肠道疾病、炎症性眼部疾病、炎症性或不稳定的膀胱疾病、牛皮癣、伴有炎症成分的皮肤疾病、慢性炎症症状、炎症性疼痛及相关的痛觉过敏和触痛、神经痛及相关的痛觉过敏和触痛、糖尿病性神经病痛、烧伤性神经痛、交感神经维持性疼痛、感觉缺失综合征、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸、泌尿、消化或血管区域内脏运动障碍、伤口、烧伤、过敏性皮肤反应、瘙痒、白癜风、一般胃肠道疾病、胃溃疡、十二指肠溃疡、腹泻、由坏死性因子引起的胃溃疡、毛发生长、血管运动或过敏性鼻炎、支气管疾病或膀胱疾病。
• Methods of modulating neurotrophin-mediated activity
  申请人：Babinski Kazimierz

  公开号：US20070093474A1

  公开（公告）日：2007-04-26

  Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.

  本发明涉及一种调节神经生长因子及其前体与神经营养受体相互作用的组合物。本发明还涉及使用该组合物的方法，包括给药方法。
• BIS BICYCLIC AMIDES AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS OF INFLAMMATORY AND NEUROPATIC PAIN
  申请人：AMGEN INC.

  公开号：EP1725529A1

  公开（公告）日：2006-11-29
• US7553848B2
  申请人：——

  公开号：US7553848B2

  公开（公告）日：2009-06-30
• US7579468B2
  申请人：——

  公开号：US7579468B2

  公开（公告）日：2009-08-25