Benzyl-isoprenyl-thioether | 71284-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl-isoprenyl-thioether
• 英文别名: benzyl-isopropenyl sulfide；Benzyl-isopropenyl-sulfid；Prop-1-en-2-ylsulfanylmethylbenzene
• CAS: 71284-83-8
• 化学式: C₁₀H₁₂S
• 分子量: 164.271
• InChiKey: XCXIBVBMXGUIHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Benzyl-isoprenyl-thioether 、 苯硫酚 生成 2-Phenylsulfon-2-benzylsulfonpropan
  参考文献：
  名称：

  2,2- 和 1,2- 二芳烷硫基和芳烷基磺基丙烷

  摘要：

  芳烷基硫醇 2 和丙酮可以使用氯化氢缩合形成 2,2-二巯基丙烷 1，当在氧气存在下加热时，将分解为硫醇 2 和异丙烯基硫醚 3。在 2 和 3 中，根据起始原料和试验条件，形成 2,2-二巯基-丙烷 1 或 1,2-二巯基-丙烷 4，可通过 NMR 光谱或通过砜 5 或8. 硫醇与异丙烯基硫化物 3 或 9 的加成也可以制备被各种基团取代的 2,2- 或 1,2- 二巯基丙烷，它们可以通过氧化转化为相应的二砜 10-17。

  DOI：

  10.1002/ardp.19723050902
• 作为产物：
  描述：

  3-Benzylmercapto-crotonsaeure 生成 Benzyl-isoprenyl-thioether
  参考文献：
  名称：

  Autenrieth, Chemische Berichte, 1896, vol. 29, p. 1669

  摘要：

  DOI：

文献信息

• Biological Polysiloxanes
  申请人：Hughes Timothy Charles

  公开号：US20090276042A1

  公开（公告）日：2009-11-05

  The present invention relates to a macromonomer having a polydimethylsiloxane backbone that has a mol % dimethyl siloxanes, b mol % siloxanes substituted with -K-RIM, c mol % siloxanes substituted with -K-RIM-Z and d mol % siloxanes substituted with -L-Z, and in which the terminal siloxane groups are tri-substituted with R, wherein RIM is a refractive index modifying group; Z is a free radically polymerisable group; K is a spacer group; L is optional and is a spacer group; each R is independently selected from an RIM, a lower alkyl group, hydrogen or Z; and a is a molar percentage of the macromonomer which is in the range of from 0 to 95 mol %; b is a molar percentage of the macromonomer which is in the range of from 5 to 99 mol %; c is a molar percentage of the macromonomer which is in the range of from 0 to 2 mol %; and d is a molar percentage of the macromonomer which is in the range of from 0 to 2 mol %; with the proviso that c and d are not both 0 mol %.

  本发明涉及一种具有聚二甲基硅氧烷骨架的大单体，其具有a摩尔％二甲基硅氧烷，b摩尔％取代为-K-RIM的硅氧烷，c摩尔％取代为-K-RIM-Z的硅氧烷和d摩尔％取代为-L-Z的硅氧烷，其中末端硅氧烷基团是三取代的R，其中RIM是折射率修饰基团；Z是自由基聚合基团；K是间隔基团；L是可选的间隔基团；每个R是独立选择的RIM，低碳烷基，氢或Z；a是大单体的摩尔百分比，范围为0至95摩尔％；b是大单体的摩尔百分比，范围为5至99摩尔％；c是大单体的摩尔百分比，范围为0至2摩尔％；d是大单体的摩尔百分比，范围为0至2摩尔％；但是c和d不能同时为0摩尔％。
• [EN] AROMATIC COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF<br/>[FR] COMPOSÉ AROMATIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION<br/>[ZH] 一种芳香化合物、其制备方法及应用
  申请人：WUHAN LL SCIENCE AND TECH DEVELOPMENT CO LTD

  公开号：WO2022161416A1

  公开（公告）日：2022-08-04

  公开了式I所示的化合物、其药学上可接受的盐、其立体异构体、其互变异构体或其同位素化合物。该化合物具有较高的P2X4拮抗活性、较好的安全性以及药代动力学性质。
• .alpha.'.beta. Elimination of carbanions derived from thioethers
  作者：Jean Francois Biellmann、Hugues d'Orchymont、Jean Louis Schmitt

  DOI：10.1021/ja00506a024

  日期：1979.6
• [EN] COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES<br/>[FR] COMPOSÉS ET METHODES POUR LA DÉGRADATION CIBLÉE DE POLYPEPTIDES DE FIBROSARCOME RAPIDEMENT ACCÉLÉRÉ
  申请人：ARVINAS INC

  公开号：WO2018119448A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.
• [EN] MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE<br/>[FR] MODULATEURS DE PROTÉOLYSE DE BTK ET PROCÉDÉS D'UTILISATION
  申请人：UNIV YALE

  公开号：WO2019177902A1

  公开（公告）日：2019-09-19

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Burton's Tyrosine Kinase (BTK). In particular, the present disclosure is directed to bifunctional compounds. One end of a bifunctional compound includes a Von Hippel-Lindau, Cereblon, Inhibitors of Apotosis Proteins, or Mouse Double-Minute Homolog 2 ligand that binds to the respective E3 ubiquitin ligase. The other end of a bifunctional compound includes a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein can be treated or prevented with compounds and compositions of the present disclosure.