(2,4-dimethylphenyl)-2-methylpropanol | 129657-28-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,4-dimethylphenyl)-2-methylpropanol
• 英文别名: (+/-)-2-methyl-1-[2.4]xylyl-propanol-(1)；(+/-)-1-Hydroxy-2-methyl-1-(2.4-dimethyl-phenyl)-propan；1-(2,4-dimethylphenyl)-isobutyl alcohol；1-(2,4-Dimethylphenyl)-2-methylpropan-1-ol
• CAS: 129657-28-9
• 化学式: C₁₂H₁₈O
• 分子量: 178.274
• InChiKey: PAOJHYNSEZUBAR-UHFFFAOYSA-N

物化性质

• 沸点：
  138 °C(Press: 18 Torr)
• 密度：
  0.956±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 copper oxide-chromium oxide 作用下， 110.0~130.0 ℃ 、23.53 MPa 条件下， 生成 (2,4-dimethylphenyl)-2-methylpropanol
  参考文献：
  名称：

  THE HYDROGENATION OF AROMATIC KETONES WITH HYDROGEN AND COPPER-CHROMIUM OXIDE CATALYST

  摘要：

  DOI：

  10.1021/jo01158a018

文献信息

• The Barbier−Grignard-Type Carbonyl Alkylation Using Unactivated Alkyl Halides in Water
  作者：Charlene C. K. Keh、Chunmei Wei、Chao-Jun Li

  DOI：10.1021/ja029649p

  日期：2003.4.1

  The aqueous Barbier-Grignard-type alkylation of aldehydes with unactivated alkyl iodides and bromides was developed. By using a combination of zinc and cuprous iodide, catalyzed by indium(I) chloride, we successfully added tertiary, secondary, and primary alkyl halides to various aromatic aldehydes in 0.07 M aqueous Na2C2O4. A mechanistic rationale for the success of the reaction has been proposed

  开发了醛与未活化的烷基碘和溴化物的水性 Barbier-Grignard 型烷基化反应。通过使用由氯化铟 (I) 催化的锌和碘化亚铜的组合，我们成功地将叔、仲和伯烷基卤化物添加到 0.07 M Na2C2O4 水溶液中的各种芳香醛中。已经提出了反应成功的机械原理。
• Process for the production of 2,6-dimethylnaphthalene
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0362651A2

  公开（公告）日：1990-04-11

  A process for production of 2,6-dimethylnaphthalene is disclosed; comprising the steps: (1) an acylation step where 2,4-dimetylisobutyrophenone is produced from m-xylene, propylene and carbon monoxide: (2) a hydrogenation step where the carbonyl group of the above 2,4-dimethylisobutyrophenone is hydrogenated: and (3) a dehydrogenation and cyclization step where the above hydrogenated product is subjected to dehydrogenation and cyclization to produce the desired 2,6-­dimethylnaphthalene. The process enables efficiently producing high quality or high purity 2,6-­dimethylnaphthalene.

  本发明公开了一种生产 2,6-二甲基萘的工艺，包括以下步骤(1)酰化步骤，由间二甲苯、丙烯和一氧化碳制得 2,4-二甲基异丁基苯酮；(2) 氢化步骤，对上述 2,4-二甲基异丁基苯酮的羰基进行氢化；以及 (3) 脱氢和环化步骤，对上述氢化产物进行脱氢和环化，制得所需的 2,6-二甲基萘。该工艺可高效生产高质量或高纯度的 2,6-二甲基萘。
• PROCESS FOR PREPARATING OPTICALLY ACTIVE COMPOUNDS
  申请人：Japan Science and Technology Corporation

  公开号：EP0916637A1

  公开（公告）日：1999-05-19

  The present invention relates to a novel, highly practical method for producing optically active compounds such as optically active alcohol and optically active amine useful for various utilities such as synthetic intermediates of drugs, liquid crystal materials, and optical resolution agents, comprising hydrogen transfer-type asymmetric reduction in the presence of a transition metal catalyst and an optically active nitrogen-containing compound or a transition metal catalyst with an optically active nitrogen-containing compound as the asymmetric ligand, and a hydrogen-donating organic or inorganic compound. In accordance with the present invention, characteristically, an optically active secondary alcohol can be recovered through the hydrogen transfer-type oxidation from racemic secondary alcohol or meso-type diol.

  本发明涉及一种生产光学活性化合物（如光学活性醇和光学活性胺）的新型、高度实用的方法，该方法可用于药物合成中间体、液晶材料和光学分辨剂等多种用途，包括在过渡金属催化剂和光学活性含氮化合物或过渡金属催化剂与光学活性含氮化合物作为不对称配体以及供氢有机或无机化合物存在下进行氢转移型不对称还原。 根据本发明，外消旋仲醇或中型二元醇通过氢转移型氧化可回收光学活性仲醇。
• Process for preparing optically active alcohols
  申请人：Japan Science and Technology Agency

  公开号：EP1300381B1

  公开（公告）日：2006-03-08
• US5023390A
  申请人：——

  公开号：US5023390A

  公开（公告）日：1991-06-11