2-呋喃-3-基吡啶-4-基胺 | 1020540-67-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-呋喃-3-基吡啶-4-基胺
• 英文名称: 2-furan-3-ylpyridin-4-ylamine
• 英文别名: 2-(3-Furanyl)-4-pyridinamine；2-(furan-3-yl)pyridin-4-amine
• CAS: 1020540-67-3
• 化学式: C₉H₈N₂O
• 分子量: 160.175
• InChiKey: JXIRFRTUNSVTEQ-UHFFFAOYSA-N

物化性质

• 沸点：
  372.1±37.0 °C(Predicted)
• 密度：
  1.204±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-4-氨基吡啶 、 3-呋喃硼酸 在 sodium tetrachloropalladate(II) potassium carbonate 作用下， 以 水 、 正丁醇 为溶剂， 反应 12.0h， 以92%的产率得到2-呋喃-3-基吡啶-4-基胺
  参考文献：
  名称：

  Efficient Suzuki−Miyaura Coupling of (Hetero)aryl Chlorides with Thiophene- and Furanboronic Acids in Aqueous n-Butanol

  摘要：

  An efficient Suzuki cross-coupling protocol enables the reaction of N-hetero and normal aryl chlorides with thiophene- and furanboronic acids. Coupling is effected in aqueous n-butanol as the solvent in near quantitative yield with a catalyst loading of 0.1 - 1 mol %. For heterocyclic substrates aqueous catalysis is found to be more efficient than Suzuki coupling under anhydrous conditions. The developed Suzuki coupling procedure utilizes biodegradable solvents and is useful for large scale reactions, as it includes the facile product separation from a biphasic solvent mixture without the need for additional organic solvents during workup.

  DOI：

  10.1021/jo8001886

文献信息

• Efficient Suzuki−Miyaura Coupling of (Hetero)aryl Chlorides with Thiophene- and Furanboronic Acids in Aqueous <i>n-</i>Butanol
  作者：Christoph A. Fleckenstein、Herbert Plenio

  DOI：10.1021/jo8001886

  日期：2008.4.1

  An efficient Suzuki cross-coupling protocol enables the reaction of N-hetero and normal aryl chlorides with thiophene- and furanboronic acids. Coupling is effected in aqueous n-butanol as the solvent in near quantitative yield with a catalyst loading of 0.1 - 1 mol %. For heterocyclic substrates aqueous catalysis is found to be more efficient than Suzuki coupling under anhydrous conditions. The developed Suzuki coupling procedure utilizes biodegradable solvents and is useful for large scale reactions, as it includes the facile product separation from a biphasic solvent mixture without the need for additional organic solvents during workup.
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  作者：Anupreet Kharbanda、Phuc Tran、Lingtian Zhang、Yuet-Kin Leung、Hong-yu Li、Brendan Frett

  DOI：10.1016/j.ejmech.2021.113763

  日期：2021.12