6-amino-6-methyl-1-heptene | 143958-76-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-amino-6-methyl-1-heptene
• 英文别名: 2-methylhept-6-en-2-amine
• CAS: 143958-76-3
• 化学式: C₈H₁₇N
• mdl: MFCD19205574
• 分子量: 127.23
• InChiKey: YSJFOFYMLACWSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-amino-6-methyl-1-heptene 在 磺酰氯 、 次氯酸叔丁酯 、 sodium hydride 、 三乙胺 作用下， 以 乙醚 为溶剂， 反应 11.0h， 生成 2-methyl-hepta-1,6-diene
  参考文献：
  名称：

  Attempts to trap radicals formed in solution by a magnesium surface

  摘要：

  The synthesis of 2,2-azo-2-methyl-6-heptene (1) is described. Photolytic decomposition of 1 in ether gave rise to the 1,1-dimethyl-5-hexenyl radical clock (2) which yielded 1,1,2-trimethylcyclopentane (3), 6-methyl-1-heptene (4), and 2-methyl-1,6-heptadiene (5) in the ratio of 1:0.72:0.56, respectively. The ratio did not change appreciably when a well-stirred mixture of 1 and 5 equiv of magnesium powder was photolyzed. Moreover, the solution gave a negative test (2,2'-biquinoline) for the presence of Grignard reagent. Thus, it has been experimentally demonstrated that the radicals formed in solution do not react with a magnesium surface to form Grignard reagents.

  DOI：

  10.1021/jo00049a026
• 作为产物：
  描述：

  5-碘-1-戊烯 在 盐酸 、 sodium hydroxide 、 正丁基锂 、 叠氮磷酸二苯酯 、 N-环己基异丙基胺 、 溶剂黄146 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 8.0h， 生成 6-amino-6-methyl-1-heptene
  参考文献：
  名称：

  Attempts to trap radicals formed in solution by a magnesium surface

  摘要：

  The synthesis of 2,2-azo-2-methyl-6-heptene (1) is described. Photolytic decomposition of 1 in ether gave rise to the 1,1-dimethyl-5-hexenyl radical clock (2) which yielded 1,1,2-trimethylcyclopentane (3), 6-methyl-1-heptene (4), and 2-methyl-1,6-heptadiene (5) in the ratio of 1:0.72:0.56, respectively. The ratio did not change appreciably when a well-stirred mixture of 1 and 5 equiv of magnesium powder was photolyzed. Moreover, the solution gave a negative test (2,2'-biquinoline) for the presence of Grignard reagent. Thus, it has been experimentally demonstrated that the radicals formed in solution do not react with a magnesium surface to form Grignard reagents.

  DOI：

  10.1021/jo00049a026

文献信息

• HCV NS3 protease inhibitors
  申请人：Holloway Katharine M.

  公开号：US20070027071A1

  公开（公告）日：2007-02-01

  The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

  本发明涉及一种公式（I）的大环化合物，该化合物可用作乙型肝炎病毒（HCV）NS3蛋白酶的抑制剂，其合成以及用于治疗或预防HCV感染的用途。
• Improved Protocol for Asymmetric, Intramolecular Heteroatom Michael Addition Using Organocatalysis: Enantioselective Syntheses of Homoproline, Pelletierine, and Homopipecolic Acid
  作者：Erik C. Carlson、Lauren K. Rathbone、Hua Yang、Nathan D. Collett、Rich G. Carter

  DOI：10.1021/jo800749t

  日期：2008.7.1

  indoline, and piperidine rings using an organocatalyzed, intramolecular heteroatom Michael addition is described. Application to the enantioselective synthesis of homoproline, homopipecolic acid, and pelletierine has been accomplished.

  描述了使用有机催化的分子内杂原子迈克尔加成构建对映体富集的吡咯烷、二氢吲哚和哌啶环的改进方案。已完成对高脯氨酸、高哌可酸和匹莱林的对映选择性合成的应用。
• HCV NS3 PROTEASE INHIBITORS
  申请人：HOLLOWAY M. Katharine

  公开号：US20090124661A1

  公开（公告）日：2009-05-14

  The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

  本发明涉及公式（I）的大环化合物，其可用作丙型肝炎病毒（HCV）NS3蛋白酶的抑制剂，其合成以及用于治疗或预防HCV感染的用途。
• US7470664B2
  申请人：——

  公开号：US7470664B2

  公开（公告）日：2008-12-30
• US8216999B2
  申请人：——

  公开号：US8216999B2

  公开（公告）日：2012-07-10