10ß-oxiranylestr-4-ene-3,17-dione | 137624-21-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 10ß-oxiranylestr-4-ene-3,17-dione
• 英文别名: (8R,9S,10S,13S,14S)-13-methyl-10-(oxiran-2-yl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
• CAS: 137624-21-6
• 化学式: C₂₀H₂₆O₃
• 分子量: 314.425
• InChiKey: JJEROASYJCSDIU-FWXIJWGRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  10ß-oxiranylestr-4-ene-3,17-dione 生成 (8S,9S,10S,13S,14S)-13-methyl-10-(thiiran-2-yl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
  参考文献：
  名称：

  CHILDERS, WAYNE E.;FURTH, PAUL S.;SHIH, MEI-JUE;ROBINSON, CECIL H., J. ORG. CHEM., 53,(1988) N 25, C. 5947-5951

  摘要：

  DOI：
• 作为产物：
  描述：

  3,17-bis(ethylenedioxy)-androst-5-en-19-al 在 trimethylsulfonium iodide 、 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 生成 10ß-oxiranylestr-4-ene-3,17-dione
  参考文献：
  名称：

  人胎盘芳香酶的新型时间依赖性抑制剂。

  摘要：

  DOI：

  10.1021/jm00109a033

文献信息

• Control of sex differentiation in fish
  申请人：MERCK & CO. INC.

  公开号：EP0514015A1

  公开（公告）日：1992-11-19

  Fish or shellfish eggs, fertilized embryos or hatched fry or shellfish are treated with steroid biosynthesis inhibitors or antagonists which prevents the conversion of androgens to estrogens. By blocking the production of estrogens the genotypic female is converted into a phenotypic male. The phenotypic conversion of females to males gives the treated fish the advantage of male growth characteristics. Such treatment will also allow the production of monosex populations of fish which can be used to limit reproduction and control overpopulation of specific aquatic environments. Steroid biosynthesis inhibitors and/or antagonists will also induce smoltification in salmon species.

  用类固醇生物合成抑制剂或拮抗剂处理鱼类或贝类的卵、受精胚胎或孵化的鱼苗或贝类，可防止雄激素转化为雌激素。通过阻止雌激素的产生，基因型雌性就会转化为表型雄性。雌性向雄性的表型转化使接受治疗的鱼类具有雄性生长特征的优势。这种处理方法还能产生单性鱼群，用于限制繁殖和控制特定水生环境中的过度繁殖。类固醇生物合成抑制剂和/或拮抗剂还能诱导鲑鱼物种的蜕皮。
• Use of anti-mullerian hormone for reversal of female sexual phenotype in poultry
  申请人：MERCK & CO. INC.

  公开号：EP0516278A1

  公开（公告）日：1992-12-02

  Fertilized poultry embryos are treated with fowl antimullerian hormone which may function as an aromatase inhibitor and may also have a trophic effect on developing gonads. Fertilized poultry embryos are also treated with steroid biosynthesis inhibitors or antagonists which prevents the conversion of androgens to estrogens, and anti-mullerian hormone (AMH). By blocking the production of estrogens and enhancing the gonads the genotypic female is converted into a phenotypic male. The phenotypic conversion of females to males gives the treated birds the advantage of male growth characteristics. A single administration of the combination prior to about day 9 of embryonic incubation results in an irreversible change in sexual phenotype which results in enhanced weight gain and feed efficiency.

  受精的家禽胚胎要使用禽抗苗勒氏管激素，这种激素可作为芳香化酶抑制剂，还可对发育中的性腺产生营养作用。受精的家禽胚胎也要使用类固醇生物合成抑制剂或拮抗剂（可防止雄激素转化为雌激素）和抗苗勒氏激素（AMH）。通过阻断雌激素的产生和增强性腺功能，基因型雌性可转化为表型雄性。雌性向雄性的表型转化使接受治疗的鸟类具有雄性生长特征的优势。在胚胎孵化的第 9 天左右，只需给药一次，性表型就会发生不可逆的改变，从而提高增重和饲料效率。
• CHILDERS, WAYNE E.;FURTH, PAUL S.;SHIH, MEI-JUE;ROBINSON, CECIL H., J. ORG. CHEM., 53,(1988) N 25, C. 5947-5951
  作者：CHILDERS, WAYNE E.、FURTH, PAUL S.、SHIH, MEI-JUE、ROBINSON, CECIL H.

  DOI：——

  日期：——
• US5162337A
  申请人：——

  公开号：US5162337A

  公开（公告）日：1992-11-10
• Novel time-dependent inhibitors of human placental aromatase
  作者：Joseph P. Burkhart、Norton P. Peet、C. Lee Wright、J. O'Neal Johnston

  DOI：10.1021/jm00109a033

  日期：1991.5