cis-1,2-bis-bromomethyl-cyclobutane | 64811-90-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: cis-1,2-bis-bromomethyl-cyclobutane
• 英文别名: cis-1,2-Bis-brommethyl-cyclobutan；cis-1,2-Bis-(bromomethyl)-cyclobutan；cis-1,2-bis-Brommethyl-cyclobutan；cis-1,2-Bis(bromomethyl)cyclobutane；(1R,2S)-1,2-bis(bromomethyl)cyclobutane
• CAS: 64811-90-1
• 化学式: C₆H₁₀Br₂
• 分子量: 241.953
• InChiKey: WYBDTOLKEKKRRM-OLQVQODUSA-N

物化性质

• 沸点：
  236.7±13.0 °C(Predicted)
• 密度：
  1.734±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  cis-1,2-bis-bromomethyl-cyclobutane 在 硫酸 、 氰化钠 作用下， 生成 (cis-cyclobutane-1,2-diyl)-di-acetic acid
  参考文献：
  名称：

  The Relative Stabilities of cis and trans Isomers. V. The Bicyclo[5.2.0]nonanes. An Extension of the Conformational Rule^1,2

  摘要：

  DOI：

  10.1021/ja01524a064
• 作为产物：
  描述：

  cis-1,2-cyclobutane dicarboxylic anhydride 在 lithium aluminium tetrahydride 、 乙醚 、 三溴化磷 、 苯 作用下， 生成 cis-1,2-bis-bromomethyl-cyclobutane
  参考文献：
  名称：

  The Relative Stabilities of cis and trans Isomers. V. The Bicyclo[5.2.0]nonanes. An Extension of the Conformational Rule^1,2

  摘要：

  DOI：

  10.1021/ja01524a064

文献信息

• Phosphine Ligands in the Palladium-Catalysed Methoxycarbonylation of Ethene: Insights into the Catalytic Cycle through an HP NMR Spectroscopic Study
  作者：Verónica de la Fuente、Mark Waugh、Graham R. Eastham、Jonathan A. Iggo、Sergio Castillón、Carmen Claver

  DOI：10.1002/chem.200903158

  日期：——

  backbone, ligands 7 and 9, containing four‐ and six‐membered ring backbones giving more active systems. The acid used as co‐catalyst has a strong influence on the activity, with excess trifluoroacetic acid affording the highest conversion, whereas excess methyl sulfonic acid inhibits the catalytic system. An in operando NMR spectroscopic mechanistic study has established the catalytic cycle and resting

  新颖顺-1,2-双（二-叔丁基膦）碳配位体6 - 9已经制备和相应的钯络合物[钯（O 3 SCH 3）（L-L）] [0 3 SCH 3 ] （L- L =二膦）32 - 35合成并表征了通过NMR光谱法和X射线衍射。这些二膦配体为钯催化的乙烯的甲氧羰基化提供了非常活泼的催化剂。活性随碳环骨架，配体7和9的大小而变化，其中包含四元和六元环主干，从而提供了更活跃的系统。用作助催化剂的酸对活性有很大影响，过量的三氟乙酸可提供最高的转化率，而过量的甲基磺酸会抑制催化体系。进行中的NMR光谱机理研究已经确定了在操作反应条件下催化剂的催化循环和静止状态。尽管催化作用遵循氢化物途径，但静止状态显示为氢化物前体络合物[Pd（O 3 SCH 3）（L- L）] [O 3 SCH 3 ]，这表明可分离/检测到的氢化物络合物是不是此机制的先决条件。
• Intermediates for the preparation of bicycloalkyl derivatives of
  申请人：Miles Laboratories, Inc.

  公开号：US04149017A1

  公开（公告）日：1979-04-10

  Useful intermediates in the preparation of bicycloalkyl analogues or derivatives of prostaglandins are represented by the formula ##STR1## wherein: X is an iodo or bromo radical; A is an acid-labile hydroxyl-protecting group; G is an integer having a value of from 0 to 10; and B is selected for the class of bicycloalkyl radicals of the formula: ##STR2## WHERE M AND P ARE INTEGERS HAVING A VALUE OF FROM 1 TO 4; N IS AN INTEGER HAVING A VALUE OF FROM 0 TO 4 SUCH THAT THE SUM OF M, N AND P IS GREATER THAN OR EQUAL TO 3 AND THE POINT OF ATTACHMENT OF THE ALKYL CHAIN (CH.sub.2).sub.g to the bicycloalkyl radical is in the (CH.sub.2).sub.m bridge or in the bridgehead position.

  该发明提供了一种制备前列腺素的双环烷基类似物或衍生物的有用中间体，其化学式为##STR1## 其中：X是碘或溴基；A是酸敏感的羟基保护基；G是一个整数，其值为0至10；B是选择自式子的双环烷基基团类：##STR2## 其中M和P是整数，其值为1至4；N是一个整数，其值为0至4，使得M、N和P的总和大于或等于3，且烷基链(CH.sub.2).sub.g的连接点与双环烷基基团连接在(CH.sub.2).sub.m桥或桥头位置。
• 5,6-Dihydro analogues of prostaglandin I.sub.2
  申请人：Miles Laboratories, Inc.

  公开号：US04206127A1

  公开（公告）日：1980-06-03

  Derivatives of prostaglandin I.sub.2 characterized by the generic structural formulae, ##STR1## are useful for inhibiting platelet aggregation or gastric acidity in individuals for whom such therapy is indicated. In the preceding structural formulae: B is CH.sub.2 OH or COOT, where T is hydrogen, an alkyl group having from 1-3 carbon atoms or a pharmacologically acceptable cation; X and Y are hydrogen or a hydroxyl group; A is methylene or ethylene; and R is a pentyl, cyclohexyl, bicyclo[3.2.0]-hept-3-yl or 1, 1-dimethylpentyl group.

  I.sub.2前列腺素的衍生物，其通用结构式为##STR1##，对于需要此类治疗的个体，用于抑制血小板聚集或胃酸度是有用的。在前面的结构式中：B是CH.sub.2 OH或COOT，其中T是氢，具有1-3个碳原子的烷基或药理学上可接受的阳离子；X和Y是氢或羟基；A是亚甲基或乙烯基；而R是戊基，环己基，双环[3.2.0]-庚-3-基或1,1-二甲基戊基基团。
• Bicycloalkyl derivatives of prostaglandins: 11-deoxy-PGE.sub.1 acids and
  申请人：Miles Laboratories, Inc.

  公开号：US04108892A1

  公开（公告）日：1978-08-22

  Novel bicycloalkyl analogues or derivatives of prostaglandin A, E, and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.

  新型的双环脂肪酸类似物或衍生物，如A、E和F前列腺素，是有用的平滑肌活性调节剂。这些化合物具有宝贵的药理学特性，可作为血小板抗聚集剂和胃抗分泌剂。这些化合物也是增加股动脉血流和降低血压和心率的宝贵药理学药剂。
• Bicycloalkyl derivatives of prostaglandins 11-deoxy-PGE.sub.2 acids and
  申请人：Miles Laboratories, Inc.

  公开号：US04115438A1

  公开（公告）日：1978-09-19

  Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.

  新型的环二萜类前列腺素A、E和F的衍生物或类似物是平滑肌活性的有用修饰剂。这些化合物具有重要的药理特性，可作为血小板抗聚集剂和胃抗分泌剂。这些化合物还是增加股动脉血流和降低血压和心率的有价值的药理剂。